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Author Details
Full Name
Georgios Skiniotis
Affiliation
Stanford University School of Medicine
ORCID
Career Start Year
1999
Papers
119
H Index
50
Expertise
CM4AI Collaborator
Nevan J Krogan (CM4AI)
PMID
Paper Title
Journal Title
Published Year
36411392
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Nat Chem Biol
2023
37160876
Structural basis for activation of CB1 by an endocannabinoid analog.
Nat Commun
2023
37290962
Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56.
Mol Pharmacol
2023
36993214
Time-resolved cryo-EM of G protein activation by a GPCR.
bioRxiv
2023
36931277
Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms.
Structure
2023
36450356
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature
2023
34281791
Drug discovery in the era of cryo-electron microscopy.
Trends Biochem Sci
2022
35804245
Author Correction: Plasticity in ligand recognition at somatostatin receptors.
Nat Struct Mol Biol
2022
35687850
Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins.
J Chem Theory Comput
2022
35418682
The tethered peptide activation mechanism of adhesion GPCRs.
Nature
2022
35385593
Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists.
Angew Chem Int Ed Engl
2022
36396979
Structure determination of inactive-state GPCRs with a universal nanobody.
Nat Struct Mol Biol
2022
36171289
Bespoke library docking for 5-HT<sub>2A</sub> receptor agonists with antidepressant activity.
Nature
2022
36064945
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun
2022
36087581
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Neuron
2022
34880492
Structure and mechanism of the SGLT family of glucose transporters.
Nature
2022
35241813
The oxytocin signaling complex reveals a molecular switch for cation dependence.
Nat Struct Mol Biol
2022
35210615
Plasticity in ligand recognition at somatostatin receptors.
Nat Struct Mol Biol
2022
35061538
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
Sci Adv
2022
34194039
G-protein activation by a metabotropic glutamate receptor.
Nature
2021
33606986
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell
2021
34862384
Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.
Nat Commun
2021
34433062
Structural insights into GIRK2 channel modulation by cholesterol and PIP<sub>2</sub>.
Cell Rep
2021
34216564
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Immunity
2021
34087182
Structure of the visual signaling complex between transducin and phosphodiesterase 6.
Mol Cell
2021
34194040
Asymmetric activation of the calcium-sensing receptor homodimer.
Nature
2021
32126208
Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.
Cell Rep
2020
31724694
A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS.
Nucleic Acids Res
2020
31945772
Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.
Nature
2020
31945771
Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Nature
2020
33007200
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Mol Cell
2020
32946782
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT<sub>2A</sub> Serotonin Receptor.
Cell
2020
32580208
Structures of metabotropic GABA<sub>B</sub> receptor.
Nature
2020
32732395
Structural insights into differences in G protein activation by family A and family B GPCRs.
Science
2020
32413291
GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps.
Structure
2020
32297861
Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.
Elife
2020
30639101
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell
2019
32296768
Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds.
ACS Pharmacol Transl Sci
2019
31243822
Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability.
Chemistry
2019
31243364
Conformational transitions of a neurotensin receptor 1-Gi1 complex.
Nature
2019
31300275
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol Cell
2019
30814739
Author Correction: Structural insights into the activation of metabotropic glutamate receptors.
Nature
2019
31073061
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science
2019
30675062
Structural insights into the activation of metabotropic glutamate receptors.
Nature
2019
29677516
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Cell
2018
30213947
Development of an antibody fragment that stabilizes GPCR/G-protein complexes.
Nat Commun
2018
30100186
Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell
2018
29899455
Structure of the µ-opioid receptor-G<sub>i</sub> protein complex.
Nature
2018
30377372
De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.
Nat Methods
2018
30270175
Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.
Structure
2018
1 - 50 of 119
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Stanford University School of Medicine
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Co-authored papers
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Charles L Brooks
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5
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University of North Carolina at Chapel Hill
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4
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Co-authored papers
4
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University of North Carolina School of Medicine
Co-authored papers
3
Arun K Shukla
Co-authored papers
3
Michel Bouvier
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers
2
David E Nichols
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers
2
Zhen-Hong Zhou
Co-authored papers
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Andrew C Kruse
Blavatnik Institute, Harvard Medical School
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Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
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Gydo C P van Zundert
Utrecht University
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2
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2
Aashish Manglik
Department of Pharmaceutical Chemistry, University of California San Francisco
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Brian E Krumm
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