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Author Details

Dean M Hartley
Rush University Medical Center
1983
55
42
PMIDPaper TitleJournal TitlePublished Year
35072136GA4GH: International policies and standards for data sharing across genomic research and healthcare.Cell Genom2021
32155778A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology.Biomolecules2020
27755974Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.Alzheimers Dement2017
28472970Communicating mild cognitive impairment diagnoses with and without amyloid imaging.Alzheimers Res Ther2017
29067293Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia.Alzheimers Dement (N Y)2016
29067294Suicidal ideation and behavior assessment in dementia studies: An Internet survey.Alzheimers Dement (N Y)2016
25510383Down syndrome and Alzheimer's disease: Common pathways, common goals.Alzheimers Dement2015
23359661Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association.J Nucl Med2013
23809369Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimerâ¿¿s Association and Society for Nuclear Medicine and Molecular Imaging.Alzheimers Dement2013
23753186Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education.J Nucl Med2013
23411394Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease.Alzheimers Dement2013
23360977Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association.Alzheimers Dement2013
22423893Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.Mol Neurodegener2012
21471641Endogenous galanin protects mouse hippocampal neurons against amyloid toxicity in vitro via activation of galanin receptor-2.J Alzheimers Dis2011
20539293Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.Nat Protoc2010
19193896Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.J Neurosci2009
18397883Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation.J Biol Chem2008
17767506A brief, but repeated, swimming protocol is sufficient to overcome amyloid beta-protein inhibition of hippocampal long-term potentiation.Eur J Neurosci2007
18000063Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.Proc Natl Acad Sci U S A2007
17625103Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha.Mol Pharmacol2007
16467520Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.J Neurosci2006
17141611The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.Curr Biol2006
16724341Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase.J Neurosci Res2006
15758153Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.J Neurosci2005
16242634Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration.Neurobiol Dis2005
15288443Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation.Neurosci Lett2004
14640676Abeta protofibrils possess a stable core structure resistant to hydrogen exchange.Biochemistry2003
12972252Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.J Mol Biol2003
12901832Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures.Neurobiol Dis2003
11986668Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.Nature2002
12167652New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.J Biol Chem2002
12124613Neurodegenerative disease: amyloid pores from pathogenic mutations.Nature2002
11311152In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.Biochem J2001
10684867Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.J Neurosci2000
11019857An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.Amyloid2000
11101888A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.Nat Struct Biol2000
11071766Presenilin affects arm/beta-catenin localization and function in Drosophila.Dev Biol2000
10516307Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.J Neurosci1999
10411596Attenuation of cortical neuronal apoptosis by gangliosides.J Pharmacol Exp Ther1999
10464339Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.J Biol Chem1999
8679207Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells.Biotechniques1996
8872313Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity.Brain Res Mol Brain Res1996
7678965AMPA receptor activation potentiates zinc neurotoxicity.Neuron1993
8093332Calcium and glutamate-induced cortical neuronal death.Res Publ Assoc Res Nerv Ment Dis1993
7683048Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.J Neurosci1993
1350203Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin.Neuron1992
2118600Folate interactions with cerebral G proteins.Neurochem Res1990
121060357-Chlorokynurenate Blocks NMDA Receptor-Mediated Neurotoxicity in Murine Cortical Culture.Eur J Neurosci1990
2308381Automated determination of excitatory amino acid neurotoxicity in cortical culture.J Neurosci Methods1990
2406381Non-NMDA receptor-mediated neurotoxicity in cortical culture.J Neurosci1990
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Collaborators

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Co-authored papers 5
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 4
University of Utah
Co-authored papers 4
Barrow Neurological Institute
Co-authored papers 2
Weill Institute for Neurosciences and Departments of Psychiatry (KY)
Co-authored papers 2
University of California San Diego
Co-authored papers 1
University of Michigan School of Public Health ann arbor
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Verily Life Sciences LLC
Co-authored papers 1
University of Oxford
Co-authored papers 1
The Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Co-authored papers 1
McGill University
Co-authored papers 1
Kavli Centre for Ethics, University of Cambridge
Co-authored papers 1
Tohoku University Graduate School of Medicine
Co-authored papers 1
European Bioinformatics Institute
Co-authored papers 1
University of Basel
Co-authored papers 1
Murdoch Children's Research Institute
Co-authored papers 1
Oregon Health & Science University
Co-authored papers 1
Co-authored papers 1
Duke-Margolis Center for Health Policy
Co-authored papers 1
University of Colorado Anschutz Medical Campus
Co-authored papers 1
Cleveland Clinic
Co-authored papers 1
Ontario Institute for Cancer Research
Co-authored papers 1
Wellcome Sanger Institute
Co-authored papers 1
University of Toronto
Co-authored papers 1
American Medical Informatics Association, Oregon Health and Science University, Oregon State University, University of Colorado Anschutz Medical Campus, University of North Carolina at Chapel Hill, University of Wisconsin-Madison
Co-authored papers 1
Broad Institute of MIT and Harvard
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Genomic Medicine Institute
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University of Pittsburgh
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Memorial Sloan Kettering Cancer Center
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