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Author Details

Beat W Sch??fer
Department of Oncology and Children's Research Center, University Children's Hospital
1985
181
61
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36630200Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.Blood Cancer Discov2023
37802557Retraction notice to Corrigendum to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia 31 (2022) 100805].Neoplasia2023
37802556Retraction notice to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia 27 (2022) 100784].Neoplasia2023
37019990The KMT2A recombinome of acute leukemias in 2023.Leukemia2023
37345159Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma.Cancers (Basel)2023
36753540Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.Sci Adv2023
35918526Author Correction: CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma.Sci Rep2022
35843705Corrigendum to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia volume 27 (2022) pp. 100784/Number C].Neoplasia2022
35739280CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma.Sci Rep2022
35839732Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe.Eur J Cancer2022
35366465Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization.Neoplasia2022
36265118Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study.JCO Precis Oncol2022
33299109Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies.Mod Pathol2021
33619227Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance.Mol Cancer Res2021
34573355High Frequency of Tumor Propagating Cells in Fusion-Positive Rhabdomyosarcoma.Genes (Basel)2021
34836971BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma.Nat Commun2021
34187933Negative correlation of single-cell <i>PAX3:FOXO1</i> expression with tumorigenicity in rhabdomyosarcoma.Life Sci Alliance2021
34211841Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells.Front Oncol2021
34329950A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA - BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors.Neoplasia2021
33419969YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells.Oncogenesis2021
32144381Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma.Cell Death Differ2020
32012890Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma.Cancers (Basel)2020
31888889Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.Cancer Res2020
33182650Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma.Cancers (Basel)2020
32744500NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.Elife2020
32934208Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity.Nat Commun2020
32416589Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage.iScience2020
30700749USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.Sci Rep2019
31824851A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas.Front Oncol2019
28701730The MLL recombinome of acute leukemias in 2017.Leukemia2018
30526876Duxbling Stem Cells Meet Tumorigenesis.Cell Stem Cell2018
29148893Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000).J Clin Oncol2018
29146205PAX3-FOXO1: Zooming in on an "undruggable" target.Semin Cancer Biol2018
25944015Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma.Curr Drug Targets2016
26623725Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.Oncotarget2016
27875302Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue.J Biol Chem2016
27760049Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.J Clin Invest2016
27572312The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.Oncotarget2016
27548722The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.PLoS One2016
26802024The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.Oncotarget2016
26189795Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma.Oncogene2016
25398439PLK1 phosphorylates PAX3-FOXO1, the inhibition of which triggers regression of alveolar Rhabdomyosarcoma.Cancer Res2015
26391565Unpeaceful roles of mutant PAX proteins in cancer.Semin Cell Dev Biol2015
26336820PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.Oncotarget2015
24550147FGFR4 signaling couples to Bim and not Bmf to discriminate subsets of alveolar rhabdomyosarcoma cells.Int J Cancer2014
25368019Rhabdomyosarcoma: current challenges and their implications for developing therapies.Cold Spring Harb Perspect Med2014
23372815Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma.PLoS One2013
23628958The MLL recombinome of acute leukemias in 2013.Leukemia2013
23761860ESF-EMBO Symposium "Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence" Sept 29-Oct 4, Polonia Castle Pultusk, Poland.Front Oncol2013
22323082Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.Int J Cancer2012
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Collaborators

Ewa Koscielniak
Co-authored papers 9
Paul Erne
Biostatistics and Prevention Institute, University of Zurich
Co-authored papers 7
Javed Khan
Center for Cancer Research, National Cancer Institute
Co-authored papers 6
Olivier Delattre
PSL Research University, Institut Curie Research Center, INSERM U, Institut Curie
Co-authored papers 5
Frederic G Barr
Center for Cancer Research
Co-authored papers 5
Emmanuelle Clappier
Saint-Louis Hospital
Co-authored papers 5
Thomas Klingebiel
Co-authored papers 4
Heinrich Kovar
St. Anna Children's Cancer Research Institute (CCRI), Medical University Vienna
Co-authored papers 4
Patricia Jaaks
Wellcome Sanger Institute
Co-authored papers 4
Simone Fulda
Co-authored papers 4
Michael Dworzak
St. Anna Children's Cancer Research Institute (CCRI)
Co-authored papers 4
Cornelia Eckert
Co-authored papers 4
Stefan Burdach
Technische Universitat Munchen
Co-authored papers 4
Didier Surdez
Balgrist University Hospital, University of Zurich (UZH)
Co-authored papers 4
Simone Hettmer
University Medical Center Freiburg, University of Freiburg
Co-authored papers 4
G??nther H S Richter
Children's Cancer Research Center
Co-authored papers 3
Young K Song
National Cancer Institute, National Institutes of Health
Co-authored papers 3
Uta Dirksen
University Hospital Essen, West German Cancer Center
Co-authored papers 3
Lee J Helman
Osteosarcoma Institute
Co-authored papers 3
Aykut Uren
Georgetown University Medical Center
Co-authored papers 2
Amy J Wagers
Joslin Diabetes Center
Co-authored papers 2
Claudia Rossig
University Children's Hospital Muenster
Co-authored papers 2
Gudrun G??hring
Hannover Medical School
Co-authored papers 2
Stephen L Lessnick
The Ohio State University College of Medicine
Co-authored papers 2
Markus Metzler
University Hospital Erlangen
Co-authored papers 2
Anton G Henssen
Co-authored papers 2
Branka Radic-Sarikas
St. Anna Children's Cancer Research Institute (CCRI), Medical University of Vienna
Co-authored papers 2
Katia Scotlandi
IRCCS Istituto Ortopedico Rizzoli
Co-authored papers 2
Peter J Houghton
The University of Texas Health Science Center at San Antonio
Co-authored papers 2
Reinhard Dummer
University Hospital Zurich
Co-authored papers 2
Release 1.2