Author details

Full Name

Farid El Oualid

Affiliation

The Netherlands Cancer Institute

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

Trey Ideker (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36350549	Characterization of the Ubiquitin and ISG15 Deconjugase Activity of SARS-CoV-1 and SARS-CoV-2 Papain-Like Protease.	Methods Mol Biol	2023
35986001	Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.	Nat Commun	2022
32511411	Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design.	bioRxiv	2020
32039147	Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1.	Front Chem	2020
33067239	Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.	Sci Adv	2020
32154221	Strategy for Development of Site-Specific Ubiquitin Antibodies.	Front Chem	2020
30528168	Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.	Bioorg Med Chem Lett	2019
31541095	Regulation of the endosomal SNX27-retromer by OTULIN.	Nat Commun	2019
31142841	Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.	Nature	2019
30651545	Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.	Nat Commun	2019
29563501	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	Nat Commun	2018
30203048	Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.	Nucleic Acids Res	2018
28919039	A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.	Cell Chem Biol	2017
28330605	Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.	Cell Chem Biol	2017
28881649	Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.	Oncotarget	2017
27182664	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	Nat Chem Biol	2016
27732584	Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.	Nature	2016
25702870	Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.	Mol Cell	2015
26542215	Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.	Cancer Res	2015
24623714	A native chemical ligation handle that enables the synthesis of advanced activity-based probes: diubiquitin as a case study.	Chembiochem	2014
24533902	Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.	FEBS J	2014
23827681	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	Cell	2013
22350915	Synthesis of atypical diubiquitin chains.	Methods Mol Biol	2012
22927162	Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis.	Chembiochem	2012
22213387	A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents.	Chembiochem	2012
22195557	The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.	Chem Biol	2011
22157957	An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.	Nat Struct Mol Biol	2011
20540574	Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.	J Am Chem Soc	2010
21117055	Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.	Angew Chem Int Ed Engl	2010
18275052	From disulfide- to thioether-linked glycoproteins.	Angew Chem Int Ed Engl	2008
17696530	Atomic-scale detection of organic molecules coupled to single-walled carbon nanotubes.	J Am Chem Soc	2007
16918362	Inhibitors of protein: geranylgeranyl transferases.	Curr Med Chem	2006
15698762	Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1.	Bioorg Med Chem	2005
16153065	A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1.	J Comb Chem	2005
15105932	Synthesis and elaboration of functionalised carbohydrate-derived spiroketals.	Org Biomol Chem	2004
15330614	Alkylated sugar amino acids: a new entry toward highly functionalized dipeptide isosters.	Org Lett	2004
15267228	Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.	J Med Chem	2004
15527261	A practical synthesis of gramicidin s and sugar amino Acid containing analogues.	J Org Chem	2004

1 - 38 of 38

Zhi Lin

Shanghai Jiao Tong University

Career Start Year 2012

Number of shared co-authors 0

Daniel Carbajo

Institut de Quimica Avancada de Catalunya (IQAC-CSIC)

Career Start Year 2011

Number of shared co-authors 0

Amit Choudhary

Broad Institute of MIT and Harvard

Career Start Year 2009

Number of shared co-authors 0

Nir London

The Weizmann Institute of Science

Career Start Year 2007

Number of shared co-authors 1

Natalia Sevillano

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 2004

Number of shared co-authors 0

Luke L Lairson

The Scripps Research Institute

Career Start Year 2003

Number of shared co-authors 1

Xiaoguang Lei

Peking-Tsinghua Center for Life Sciences, Peking University

Career Start Year 2003

Number of shared co-authors 0

Craig J Thomas

Center for Cancer Research, National Cancer Institute

Career Start Year 2001

Number of shared co-authors 0

Ronald D Seidel

Albert Einstein College of Medicine

Career Start Year 2001

Number of shared co-authors 0

Alan Saghatelian

Salk Institute for Biological Studies

Career Start Year 2000

Number of shared co-authors 0

Jason E Gestwicki

Institute for Neurodegenerative Diseases, University of California San Francisco

Career Start Year 2000

Number of shared co-authors 0

Fei Liu

Macquarie University

Career Start Year 1998

Number of shared co-authors 0

Rodrigo J Carbajo

Oncology R&D

Career Start Year 1997

Number of shared co-authors 0

Suzanne Ackloo

University of Toronto

Career Start Year 1997

Number of shared co-authors 0

Jack Taunton

University of California san francisco

Career Start Year 1996

Number of shared co-authors 1

Bj??rn G Voldborg

Technical University of Denmark

Career Start Year 1995

Number of shared co-authors 0

Paul J Hergenrother

University of Illinois at Urbana-Champaign

Career Start Year 1995

Number of shared co-authors 0

Tom W Muir

Princeton University

Career Start Year 1993

Number of shared co-authors 1

Eduard Sergienko

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

Career Start Year 1992

Number of shared co-authors 0

Carolyn R Bertozzi

Stanford University

Career Start Year 1992

Number of shared co-authors 0

Petr Nov??k

Institute of Microbiology of the CAS

Career Start Year 1991

Number of shared co-authors 0

Yue-Ming Li

Memorial Sloan Kettering Cancer Center

Career Start Year 1990

Number of shared co-authors 0

Philip A Cole

Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School

Career Start Year 1990

Number of shared co-authors 0

Laura L Kiessling

Massachusetts Institute of Technology

Career Start Year 1987

Number of shared co-authors 0

Kevan M Shokat

University of California San Francisco

Career Start Year 1987

Number of shared co-authors 4

Stuart L Schreiber

Broad Institute

Career Start Year 1985

Number of shared co-authors 0

David S Lawrence

University of North Carolina

Career Start Year 1984

Number of shared co-authors 0

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 1

Ronald T Raines

Massachusetts Institute of Technology

Career Start Year 1981

Number of shared co-authors 0

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 0

row(s) 1 - 30 of 30

Huib Ovaa

Leiden University Medical Center

Co-authored papers 18

Reggy Ekkebus

Netherlands Cancer Institute

Co-authored papers 5

Fred van Leeuwen

Netherlands Cancer Institute, University of Amsterdam

Co-authored papers 2

Tibor van Welsem

Netherlands Cancer Institute

Co-authored papers 2

Lewis E Kay

University of Toronto

Co-authored papers 1

Iris J E Stulemeijer

Netherlands Cancer Institute

Co-authored papers 1

Dominique Morais

Netherlands Cancer Institute

Co-authored papers 1

Deepani W Poramba-Liyanage

Utrecht University Utrecht The Netherlands.

Co-authored papers 1

Rolf Boelens

Utrecht University

Co-authored papers 1

Rohith Srivas

Amgen Inc.

Co-authored papers 1

Haico van Attikum

Leiden University Medical Center

Co-authored papers 1

Michael H Glickman

Technion-Israel Institute of Technology

Co-authored papers 1

David Fushman

University of Maryland, College Park

Co-authored papers 1

Hanneke Vlaming

Blavatnik Institute, Harvard Medical School

Co-authored papers 1

Kirsten van Harten

Netherlands Cancer Institute

Co-authored papers 1

Anja Basters

Co-authored papers 1

Frank C P Holstege

Princess Maxima Center for Pediatric Oncology

Co-authored papers 1

Tessy Korthout

Oncode Institute

Co-authored papers 1

Trey Ideker (CM4AI)

University of California San Diego

Co-authored papers 1

Lars Ketscher

Co-authored papers 1

Thom M Molenaar

Amsterdam UMC location Vrije Universiteit Amsterdam

Co-authored papers 1

Klaus-Peter Knobeloch

Co-authored papers 1

Tineke L Lenstra

the Netherlands Cancer Institute, Oncode Institute

Co-authored papers 1

Su Ming Sun

Leiden University Medical Center

Co-authored papers 1

Zanlin Yu

University of California at San Francisco

Co-authored papers 1

Krzysztof Paw??owski

Kashubian Center for Heart and Vascular Diseases in Wejherowo, Pomeranian Hospitals

Co-authored papers 1

1 - 26

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