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Author Details

Michael Zinda
Repare Therapeutics Inc.
1998
46
27
PMIDPaper TitleJournal TitlePublished Year
36944408Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel.J Mol Diagn2023
35078243ATM Germline-Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics, and Potential Therapeutic Implications.J Natl Cancer Inst2022
35444283CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.Nature2022
35830811Guiding ATR and PARP inhibitor combinationswith chemogenomic screens.Cell Rep2022
34911817RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.Mol Cancer Ther2022
35121901The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.Nat Cancer2021
33795234Synthetic Lethality in Cancer Therapeutics: The Next Generation.Cancer Discov2021
32297743Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.J Med Chem2020
31699827AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells.Clin Cancer Res2020
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
29636547BRD4 facilitates replication stress-induced DNA damage response.Oncogene2018
29856615Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.J Med Chem2018
30036377BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.PLoS One2018
30297535Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.Cancer Res2018
30335946Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.ACS Chem Biol2018
28615361Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.Sci Transl Med2017
28371485Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.ChemMedChem2017
29245897Comparative analysis of primary <i>versus</i> relapse/refractory DLBCL identifies shifts in mutation spectrum.Oncotarget2017
29212548Generation of stable PDX derived cell lines using conditional reprogramming.Mol Cancer2017
27025877JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.Sci Signal2016
26614408Identification of azabenzimidazoles as potent JAK1 selective inhibitors.Bioorg Med Chem Lett2016
27472462Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.Oncotarget2016
27472392Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation.Oncotarget2016
27573426AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.Mol Cancer Ther2016
27189703Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.Leuk Lymphoma2016
25537515Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers.Oncotarget2015
26351323Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.Mol Cancer Ther2015
25779944The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.Clin Cancer Res2015
24462666Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases.Bioorg Med Chem Lett2014
24577942Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation.Mol Cancer Ther2014
24359159Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.J Med Chem2014
23562594Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.Bioorg Med Chem Lett2013
23942095Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer.Clin Cancer Res2013
22305584Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.Bioorg Med Chem Lett2012
21138246Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.J Med Chem2011
21920898Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.Cancer Res2011
21493067In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.Bioorg Med Chem Lett2011
20144546Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors.Bioorg Med Chem Lett2010
19112018Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.Bioorg Med Chem Lett2009
19857966Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.Bioorg Med Chem Lett2009
19962667The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.Cancer Cell2009
18775810Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.J Biol Chem2008
11162641Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.Biochem Biophys Res Commun2001
11489829AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.Clin Cancer Res2001
9808785The histidine kinase dhkC regulates the choice between migrating slugs and terminal differentiation in Dictyostelium discoideum.Dev Biol1998
9576830The hybrid histidine kinase dhkB regulates spore germination in Dictyostelium discoideum.Dev Biol1998
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School of Clinical Sciences at Monash Health, Monash University
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