Author details

Full Name

Keren Yizhak

Affiliation

ORCID

Career Start Year

2010

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37066412	Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.	bioRxiv	2023
37965137	Metabolic predictors of response to immune checkpoint blockade therapy.		2023
36634707	Targeting TBK1 to overcome resistance to cancer immunotherapy.	Nature	2023
35243413	Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.	Cell Rep Med	2022
35654823	Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample.	Nature Communications	2022
33762352	Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions.	Cancer Immunol Res	2021
31942075	B cells and tertiary lymphoid structures promote immunotherapy response.	Nature	2020
31358999	PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1<sup>+</sup>CD38<sup>hi</sup> cells and anti-PD-1 resistance.	Nat Immunol	2019
31551574	Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1<sup>+</sup>CD38<sup>hi</sup> cells and anti-PD-1 resistance.	Nat Immunol	2019
30633907	Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.	Cell	2019
31171663	RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues.	Science	2019
29674595	Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.	Science	2018
30388456	Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.	Cell	2018
29196508	An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.	Mol Syst Biol	2017
28360267	Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.	Science	2017
29070816	Resistance to checkpoint blockade therapy through inactivation of antigen presentation.	Nat Commun	2017
29198524	Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.	Cell	2017
27997585	Essential Genes Embody Increased Mutational Robustness to Compensate for the Lack of Backup Genetic Redundancy.	PLoS One	2016
27406679	A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer.	Sci Rep	2016
27806376	Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.	Nature	2016
26130389	Modeling cancer metabolism on a genome scale.	Mol Syst Biol	2015
26560030	Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.	Nature	2015
25086087	A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.	Mol Syst Biol	2014
25415239	Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.	Elife	2014
24866123	Maximal sum of metabolic exchange fluxes outperforms biomass yield as a predictor of growth rate of microorganisms.	PLoS One	2014
25127241	Integrating transcriptomics with metabolic modeling predicts biomarkers and drug targets for Alzheimer's disease.	PLoS One	2014
23731523	Metabolically re-modeling the drug pipeline.	Curr Opin Pharmacol	2013
24153335	Model-based identification of drug targets that revert disrupted metabolism and its application to ageing.	Nat Commun	2013
24280180	p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production.	Cancer Metab	2013
21451589	Metabolic modeling of endosymbiont genome reduction on a temporal scale.	Mol Syst Biol	2011
20529914	Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model.	Bioinformatics	2010