Author details

Full Name

Minjun Chen

Affiliation

ORCID

Career Start Year

2000

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37460037	In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review.		2023
34607018	A systematic comparison of hepatobiliary adverse drug reactions in FDA and EMA drug labeling reveals discrepancies.	Drug Discov Today	2022
35528969	Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science.	Journal of Clinical and Translational Hepatology	2022
35905417	Whole Exome Sequencing Reveals Genetic Variants in HLA Class II Genes Associated With Transplant-free Survival of Indeterminate Acute Liver Failure.	Clinical and Translational Gastroenterology	2022
35296201	Integrative approaches for studying the role of noncoding RNAs in influencing drug efficacy and toxicity.	Expert Opin Drug Metab Toxicol	2022
35188640	Machine Learning Models for Predicting Liver Toxicity.	Methods Mol Biol	2022
34939028	BERT-Based Natural Language Processing of Drug Labeling Documents: A Case Study for Classifying Drug-Induced Liver Injury Risk.	Front Artif Intell	2021
34281077	Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose.	Int J Environ Res Public Health	2021
33845060	Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.	Journal of Hepatology	2021
33737635	Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review.	Scientific Reports	2021
33666709	Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machineÂ learning approach.	Archives of Toxicology	2021
34682349	Machine Learning to Identify Interaction of Single-Nucleotide Polymorphisms as a Risk Factor for Chronic Drug-Induced Liver Injury.	International Journal of Environmental Research and Public Health	2021
31707421	Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI).	ALTEX	2020
32424219	Cancer genomics predicts disease relapse and therapeutic response to neoadjuvant chemotherapy of hormone sensitive breast cancers.	Sci Rep	2020
32174981	Editorial: Deep Learning for Toxicity and Disease Prediction.	Frontiers in Genetics	2020
31720699	The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis.	Arch Toxicol	2020
31371307	MicroRNA-138 negatively regulates the hypoxia-inducible factor 1Î± to suppress melanoma growth and metastasis.	Biology Open	2019
30195258	The influence of drug properties and host factors on delayed onset of symptoms in drug-induced liver injury.	Liver International	2019
29407200	Interplay of gender, age and drug properties on reporting frequency of drug-induced liver injury.	Regul Toxicol Pharmacol	2018
28931315	The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury.	Expert Rev Gastroenterol Hepatol	2018
30426823	Target-specific toxicity knowledgebase (TsTKb): a novel toolkit for in silico predictive toxicology.	Environmental Carcinogenesis and Ecotoxicology Reviews	2018
30628866	A review on machine learning methods for in silico toxicity prediction.	Environmental Carcinogenesis and Ecotoxicology Reviews	2018
30274144	The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity.	Int J Mol Sci	2018
29443401	Pediatric Intestinal Failure-Associated Liver Disease: Challenges in Identifying Clinically Relevant Biomarkers.	JPEN J Parenter Enteral Nutr	2018
29701277	Review article: therapeutic bile acids and the risks for hepatotoxicity.	Aliment Pharmacol Ther	2018
28164116	Drug-Induced Liver Injury.	BioMed Research International	2017
28350954	Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury.	J Chem Inf Model	2017
28640208	Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury.	Int J Mol Sci	2017
28849567	ArrayTrack: An FDA and Public Genomic Tool.	Methods Mol Biol	2017
28327365	Direct-Acting Antivirals for Chronic Hepatitis C: Can Drug Properties Signal Potential for LiverÂ Injury?	Gastroenterology	2017
29229971	Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.	Sci Rep	2017
27689095	Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.	Biomed Res Int	2016
27302180	A Model to predict severity of drug-induced liver injury in humans.	Hepatology	2016
26948801	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.	Drug Discov Today	2016
27311476	QSAR Models at the US FDA/NCTR.	Methods Mol Biol	2016
26501477	NETBAGs: a network-based clustering approach with gene signatures for cancer subtyping analysis.	Biomark Med	2015
25697799	Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure.	Chemical Research in Toxicology	2015
25912521	Drug-induced liver injury: Interactions between drug properties and host factors.	Journal of Hepatology	2015
24958025	A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model.	Arch Toxicol	2014
25559675	Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study.	BMC Bioinformatics	2014
24464804	High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury.	Drug Metab Dispos	2014
24857265	Predicting idiosyncratic drug-induced liver injury: some recent advances.	Expert Rev Gastroenterol Hepatol	2014
24521015	Toward predictive models for drug-induced liver injury in humans: are we there yet?	Biomark Med	2014
23258593	High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury.	Hepatology	2013
23997115	Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs.	Toxicol Sci	2013
24267543	A systems approach for analysis of high content screening assay data with topic modeling.	BMC Bioinformatics	2013
23486446	The liver toxicity knowledge base: a systems approach to a complex end point.	Clin Pharmacol Ther	2013
23395088	A unifying ontology to integrate histological and clinical observations for drug-induced liver injury.	Am J Pathol	2013
22122743	Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?	Chem Res Toxicol	2012
22790972	A decade of toxicogenomic research and its contribution to toxicological science.	Toxicol Sci	2012