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Author Details

Rajendra Kumar-Singh
University of California San Diego
1991
79
28
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36992361A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation.Viruses2023
34928772Infantile Aphakic Glaucoma: A Proposed Mechanism.J Pediatr Ophthalmol Strabismus2022
35076277Decoding Transcription Regulatory Mechanisms Associated with <i>Coccidioides immitis</i> Phase Transition Using Total RNA.mSystems2022
32719457Structural basis of CD4 downregulation by HIV-1 Nef.Nat Struct Mol Biol2020
31941773A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.J Virol2020
31082363The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials.Exp Eye Res2019
31480747Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins.Cells2019
29678656Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis.Mol Ther2018
30135209Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes.J Biol Chem2018
29864441G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection.Exp Eye Res2018
28918058Reducible PEG-POD/DNA Nanoparticles for Gene Transfer In Vitro and In Vivo: Application in a Mouse Model of Age-Related Macular Degeneration.Mol Ther Nucleic Acids2017
28504462Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors.Traffic2017
26923800G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection.Exp Eye Res2016
25427613AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury.Gene Ther2015
26369397Adenovirus-mediated delivery of Factor H attenuates complement C3 induced pathology in the murine retina: a potential gene therapy for age-related macular degeneration.J Gene Med2015
26368850Topical application of a G-Quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration.Exp Eye Res2015
25917932Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59.J Gene Med2015
24670995AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice.Gene Ther2014
24755227Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2.J Biol Chem2014
22809998Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa.Gene Ther2013
24278479Extended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration.PLoS One2013
24106121Aurintricarboxylic acid inhibits complement activation, membrane attack complex, and choroidal neovascularization in a model of macular degeneration.Invest Ophthalmol Vis Sci2013
24130789Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration.PLoS One2013
24167638Adeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in mice.PLoS One2013
23766509Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP).J Biol Chem2013
23221546Stimulation of NF-κB activity by the HIV restriction factor BST2.J Virol2013
22705789Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.Nat Struct Mol Biol2012
21357400Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina.Invest Ophthalmol Vis Sci2011
21552568A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration.PLoS One2011
21720565Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium.PLoS One2011
21344542Nuclear targeted delivery of macromolecules to retina and cornea.J Gene Med2011
21307887Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration.Gene Ther2011
19733192Cell penetrating peptide POD mediates delivery of recombinant proteins to retina, cornea and skin.Vision Res2010
20700110POD nanoparticles expressing GDNF provide structural and functional rescue of light-induced retinal degeneration in an adult mouse.Mol Ther2010
20688727Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degeneration.Invest Ophthalmol Vis Sci2010
20688520BST-2/tetherin: a new component of the innate immune response to enveloped viruses.Trends Microbiol2010
20671268Engineered zinc finger nuclease-mediated homologous recombination of the human rhodopsin gene.Invest Ophthalmol Vis Sci2010
19892875Adenovirus vectors targeting distinct cell types in the retina.Invest Ophthalmol Vis Sci2010
19937991A poly(ethylene) glycolylated peptide for ocular delivery compacts DNA into nanoparticles for gene delivery to post-mitotic tissues in vivo.J Gene Med2010
20020046An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex.PLoS One2009
17923842Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea.Mol Ther2008
18565565Barriers for retinal gene therapy: separating fact from fiction.Vision Res2008
18487376Evaluation of adenovirus-delivered human CD59 as a potential therapy for AMD in a model of human membrane attack complex formation on murine RPE.Invest Ophthalmol Vis Sci2008
17505470Improved retinal transduction in vivo and photoreceptor-specific transgene expression using adenovirus vectors with modified penton base.Mol Ther2007
17507457Mutation in CEP290 discovered for cat model of human retinal degeneration.J Hered2007
16877421Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD.Invest Ophthalmol Vis Sci2006
15877050Towards mutation-independent silencing of genes involved in retinal degeneration by RNA interference.Gene Ther2005
15183060Adenovirus type 5 pseudotyped with adenovirus type 37 fiber uses sialic acid as a cellular receptor.Virology2004
12842436Evidence of protein transduction but not intercellular transport by proteins fused to HIV tat in retinal cell culture and in vivo.Mol Ther2003
12498777Intercellular trafficking of adenovirus-delivered HSV VP22 from the retinal pigment epithelium to the photoreceptors--implications for gene therapy.Mol Ther2002
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Collaborators

John Guatelli
University of California San Diego, USA VA San Diego Healthcare System
Co-authored papers 10
Charlotte A Stoneham
University of California
Co-authored papers 6
Xiaofei Jia
University of Massachusetts Dartmouth
Co-authored papers 5
Marissa Suarez
VA San Diego Healthcare System
Co-authored papers 3
Peter W Ramirez
California State University Long Beach
Co-authored papers 3
Mark Lawler
Queens University Belfast Belfast
Co-authored papers 2
Javier Ben??tez
Instituto de Salud Carlos III
Co-authored papers 1
Partho Ghosh
University of California
Co-authored papers 1
Yonghwa Kwon
University of Massachusetts Dartmouth
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Robyn M Kaake
J. David Gladstone Institutes
Co-authored papers 1
Jeanne M Frederick
University of Utah School of Medicine
Co-authored papers 1
Jacob Kress
University of Massachusetts Dartmouth
Co-authored papers 1
Joel O Wertheim
University of California
Co-authored papers 1
Sascha H Duttke
College of Veterinary Medicine, Washington State University
Co-authored papers 1
Jason E Stajich
University of California-Riverside
Co-authored papers 1
Joseph Caprioli
Co-authored papers 1
Robert M Stephens
Frederick National Laboratory for Cancer Research, Inc.
Co-authored papers 1
Mohammad Karimian Shamsabadi
University of Massachusetts Dartmouth
Co-authored papers 1
Sonya E Neal
University of California San Diego, United States Howard Hughes Medical Institute
Co-authored papers 1
Christopher Benner
Michigan State University College of Human Medicine
Co-authored papers 1
Jacky M K Kwong
Co-authored papers 1
Stephen J O'Brien
Co-authored papers 1
Thomas Meitinger
Technical University of Munich, Institute of Human Genetics
Co-authored papers 1
Bertram M??ller-Myhsok
Max Planck Institute of Psychiatry
Co-authored papers 1
Alejandro A Sch??ffer
National Cancer Institute, National Institutes of Health
Co-authored papers 1
Aaron F Carlin
Co-authored papers 1
Massimo Pizzato
Co-authored papers 1
Release 1.2