Author details

Full Name

Timo Otonkoski

Affiliation

ORCID

Career Start Year

1981

Papers

194

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36876139	Comprehensive characterization of the embryonic factor LEUTX.	iScience	2023
37556323	Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets.		2023
35241836	Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.	Nature Biotechnology	2022
36289205	The type 1 diabetes gene TYK2 regulates Î²-cell development and its responses to interferon-Î±.	Nature Communications	2022
35948367	Islet Gene View-a tool to facilitate islet research.	Life Sci Alliance	2022
36136756	Differentiating functional human islet-like aggregates from pluripotent stem cells.	STAR Protocols	2022
35402882	<i>DUX4</i> is a multifunctional factor priming human embryonic genome activation.	iScience	2022
36114074	Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells.	Differentiation	2022
35777358	Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2.	Stem Cell Reports	2022
36581877	Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.		2022
36726462	beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities.		2022
34215672	Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism.		2022
35063129	CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells.	Stem Cell Reports	2022
35044456	PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic Î²-Cells in Autoimmune Diabetes.		2022
35250887	Stem Cell Based Models in Congenital Hyperinsulinism - Perspective on Practicalities and Possibilities.	Frontiers in Endocrinology	2022
35244743	Maturation of beta cells: lessons from in vivo and in vitro models.	Diabetologia	2022
35165416	Metabolic determination of cell fate through selective inheritance of mitochondria.	Nat Cell Biol	2022
34822772	Simultaneous high-efficiency base editing and reprogramming of patient fibroblasts.	Stem Cell Reports	2021
33475139	Long-Term Outcome and Treatment in Persistent and Transient Congenital Hyperinsulinism: A Finnish Population-Based Study.	Journal of Clinical Endocrinology and Metabolism	2021
33500254	Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress.	Diabetes	2021
33404684	SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism.	Diabetologia	2021
33164986	YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.	J Clin Invest	2020
32170320	Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism.	Journal of Clinical Endocrinology and Metabolism	2020
32437855	ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons.	Neurobiology of Disease	2020
32867368	Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter.	Viruses	2020
31311800	Early Detection of Peripheral Blood Cell Signature in Children Developing Î²-Cell Autoimmunity at a Young Age.		2019
31676859	Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.	Nature Genetics	2019
31623497	Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.	Upsala Journal of Medical Sciences	2019
30270471	Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic Î²-Cell Pathology.	Stem Cells	2019
30305368	MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic Î²-Cell Mass in Mice.		2019
31161346	Genome editing of human pancreatic beta cell models: problems, possibilities and outlook.	Diabetologia	2019
30787321	Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.	Nat Commun	2019
30728358	Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.	Nat Commun	2019
30032427	MANF protects human pancreatic beta cells against stress-induced cell death.	Diabetologia	2018
29980666	Human pluripotent reprogramming with CRISPR activators.	Nat Commun	2018
30247717	Pancreatic Î²-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.	Nucleic Acids Research	2018
30412052	Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.	eLife	2018
28925359	Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9.	Stem Cell Research	2017
28952927	Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9.	Stem Cell Research	2017
28625538	A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion.	Stem Cell Reports	2017
28880267	p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming.	Cell Death and Disease	2017
28402852	An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.	Cell Reports	2017
27167055	Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population.	Journal of Clinical Endocrinology and Metabolism	2016
27114183	sept7b is required for the differentiation of pancreatic endocrine progenitors.	Scientific Reports	2016
26840096	Report from IPITA-TTS Opinion Leaders Meeting on the Future of Î²-Cell Replacement.	Transplantation	2016
27007444	New tools for experimental diabetes research: Cellular reprogramming and genome editing.	Upsala Journal of Medical Sciences	2016
27329070	Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.	Tissue Engineering - Part A.	2016
27082827	Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of Î²-Cell Replacement.	Transplantation	2016
26777058	Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential.	Stem Cell Reports	2016
26696518	Human pluripotent stem cell based islet models for diabetes research.		2015