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Author Details

Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
1997
118
32
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36708680Elevated labile iron in castration-resistant prostate cancer is targetable with ferrous iron-activatable antiandrogen therapy.Eur J Med Chem2023
37905049Development of covalent chemogenetic K<sub>2P</sub> channel activators.bioRxiv2023
37788497Imaging-Selected Host Responses in the Context of Infections.J Infect Dis2023
37820725In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin.Cell Chem Biol2023
37676236Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3Ͽ/ERα Protein-Protein Interaction from Nonselective Fragments.J Am Chem Soc2023
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
37455289From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.Angew Chem Int Ed Engl2023
37077383Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials.ACS Med Chem Lett2023
37406165Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6.J Med Chem2023
37104712Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.J Am Chem Soc2023
36753419Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis.Cell Rep2023
35262628Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors.J Exp Med2022
35653508Structure-Based Ligand Design Targeting <i>Pseudomonas aeruginosa</i> LpxA in Lipid A Biosynthesis.ACS Infect Dis2022
35696654Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen-Bond-Accepting Amino Acid Side Chains.ChemMedChem2022
35364007Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.Cell Chem Biol2022
35215301Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads.Pharmaceuticals (Basel)2022
33175511Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.ACS Infect Dis2021
35503277Correction: Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron.RSC Adv2021
35497286Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron.RSC Adv2021
33714882Emerging role of ferrous iron in bacterial growth and host-pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy.Curr Opin Chem Biol2021
34704263Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase.FEBS Lett2021
34550070A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.Elife2021
33246980Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.J Nucl Med2021
33261861Ferrous Iron-Dependent Pharmacology.Trends Pharmacol Sci2021
32369341Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.ACS Infect Dis2020
33124817Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis.J Am Chem Soc2020
32302100Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.ACS Chem Biol2020
31140267Targeting Mobilization of Ferrous Iron in <i>Pseudomonas aeruginosa</i> Infection with an Iron(II)-Caged LpxC Inhibitor.ACS Infect Dis2019
31667472Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.Brain Commun2019
31882444Oscillatory cAMP signaling rapidly alters H3K4 methylation.Life Sci Alliance2019
32774871An Empirical Study of Amide-Heteroarene Ï¿-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase.Org Chem Front2019
31353319Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.Cell Chem Biol2019
31483651Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.J Med Chem2019
31041393Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.ACS Cent Sci2019
30942078Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.ACS Infect Dis2019
28945980A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments.SLAS Discov2018
30089357Protein and Chemical Determinants of BL-1249 Action and Selectivity for K<sub>2P</sub> Channels.ACS Chem Neurosci2018
29844038Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.Antimicrob Agents Chemother2018
30340023Cilia-Associated Oxysterols Activate Smoothened.Mol Cell2018
29569925Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.Mol Pharm2018
29599213Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.Science2018
27449257Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery.Curr Top Med Chem2017
28416550Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes.Antimicrob Agents Chemother2017
29033317Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.Cell Chem Biol2017
29045385USP7 small-molecule inhibitors interfere with ubiquitin binding.Nature2017
29239726cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool.Elife2017
29138321In vivo bioluminescence imaging of labile iron accumulation in a murine model of <i>Acinetobacter baumannii</i> infection.Proc Natl Acad Sci U S A2017
28692297Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.J Med Chem2017
28759216Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.J Am Chem Soc2017
26789650Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.ChemMedChem2016
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Collaborators

Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 28
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 11
Brian R Hearn
Department of Pharmaceutical Chemistry and, University of California san francisco
Co-authored papers 10
Stanley B Prusiner
Weill Institute for Neurosciences, University of California San Francisco
Co-authored papers 9
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Philip J Rosenthal
University of California at San Francisco
Co-authored papers 7
Kurt Giles
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 5
Punitha Vedantham
Department of Pharmaceutical Chemistry and, University of California san francisco
Co-authored papers 5
Peter Walter
University of California san francisco
Co-authored papers 5
Allegra T Aron
Co-authored papers 4
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Daniel L Minor
Cardiovascular Research Institute, University of California san francisco
Co-authored papers 3
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Juan A Oses-Prieto
Co-authored papers 3
Sina Ghaemmaghami
University of Rochester
Co-authored papers 3
Carmela Sidrauski
Calico Life Sciences LLC
Co-authored papers 3
Stephen J DeArmond
Co-authored papers 3
Jack Taunton
University of California san francisco
Co-authored papers 3
James A Wells
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 3
Abby Oehler
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 3
Jordan C Tsai
University of California san francisco
Co-authored papers 3
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Jonathan E Gable
Novartis Institute for Tropical Diseases
Co-authored papers 2
Eric A Collisson
University of California san francisco
Co-authored papers 2
Conor R Caffrey
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 2
David W Sant
Noorda College of Osteopathic Medicine
Co-authored papers 2
Markus-Frederik Bohn
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Brian K Shoichet
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Release 1.2