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Author Details

Nigel J Cairns
Washington University School of Medicine
1988
453
104
PMIDPaper TitleJournal TitlePublished Year
36331161Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always.Ann Neurol2023
35609137Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease.Alzheimers Dement2023
37461624Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.medRxiv2023
35060360Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.Ann Clin Transl Neurol2022
35580594Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology.Brain2022
33367843Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.J Neuropathol Exp Neurol2021
33589841Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nat Genet2021
34319442Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.Acta Neuropathol2021
34090937Hippocampal neurobiology and function in an aged mouse model of TDP-43 proteinopathy in an APP/PSEN1 background.Neurosci Lett2021
33253432Is Levodopa Response a Valid Indicator of Parkinson's Disease?Mov Disord2021
32487123From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline.Mol Neurodegener2020
33554027Effusive-constrictive cholesterol pericarditis: a case report.Eur Heart J Case Rep2020
31996268Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies.Acta Neuropathol Commun2020
31725472Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument.Alzheimer Dis Assoc Disord2020
31829926Neuropathological findings in a South Korean patient with Perry syndrome.Clin Neuropathol2020
33376986Genetic risk for Alzheimer's disease influences neuropathology via multiple biological pathways.Brain Commun2020
33213513Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.Acta Neuropathol Commun2020
33150749Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease.Ann Clin Transl Neurol2020
32602253Parkinson disease clinical subtypes: key features &amp; clinical milestones.Ann Clin Transl Neurol2020
32304374The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions.Alzheimer Dis Assoc Disord2020
30336198Distinct cytokine profiles in human brains resilient to Alzheimer's pathology.Neurobiol Dis2019
30953760Heritability and genetic variance of dementia with Lewy bodies.Neurobiol Dis2019
30897203Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.Brain2019
30739198Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.Acta Neuropathol2019
31068200TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.Mol Neurodegener2019
30820047Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet2019
30753379Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.Brain2019
30901713Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease.Neuroimage Clin2019
30321505Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.Alzheimers Dement2019
30478174Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.J Biol Chem2019
30564964Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change.Neurol Sci2019
30448004A comprehensive screening of copy number variability in dementia with Lewy bodies.Neurobiol Aging2019
29263008Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.Lancet Neurol2018
30217935Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.Neurology2018
29945202The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses.J Neuropathol Exp Neurol2018
29880032Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.Genome Med2018
29979775Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls.PLoS One2018
30246887Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease.Ann Neurol2018
30292840Widespread distribution of tauopathy in preclinical Alzheimer's disease.Neurobiol Aging2018
30546007Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP.Transl Psychiatry2018
30417072Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.Alzheimers Dement (Amst)2018
29724592Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.Lancet Neurol2018
29522171Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.Brain2018
29438042In vivo [<sup>18</sup>F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease.Neurology2018
29742105White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.PLoS One2018
29715546TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics.Neurosci Lett2018
29623063Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer <i>In Vivo</i> and Exhibit Nanoscale Heterogeneity.Front Neurol2018
29397305Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study.Lancet Neurol2018
29311743TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.Nat Neurosci2018
26998921A quantitative study of tau pathology in 11 cases of chronic traumatic encephalopathy.Neuropathol Appl Neurobiol2017
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Collaborators

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Co-authored papers 95
University of Pennsylvania
Co-authored papers 48
Icahn School of Medicine at Mount Sinai
Co-authored papers 42
Mayo Clinic Jacksonville
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Mayo Clinic Florida
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Co-authored papers 26
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Butler Hospital, and Warren Alpert Medical School of Brown University
Co-authored papers 21
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Co-authored papers 21
University of California
Co-authored papers 21
University of New South Wales
Co-authored papers 20
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 20
University of California San Francisco
Co-authored papers 18
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Washington University St. Louis
Co-authored papers 18
Stark Neurosciences Research Institute, Indiana University School of Medicine (IUSM)
Co-authored papers 17
Mallinckrodt Institute of Radiology, Washington University School of Medicine
Co-authored papers 17
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Stanford University
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UK Dementia Research Institute, University College London
Co-authored papers 16
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Massachusetts General Hospital and Harvard Medical School
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UCSF Weill Institute for Neurosciences, University of California san francisco
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Northwestern University Feinberg School of Medicine
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Brigham and Women's Hospital, Broad Institute Ariadne Labs and Harvard Medical School
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Alzheimer's Therapeutic Research Institute, University of Southern California
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