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Author Details

Simon Lovestone
Janssen Medical Ltd
1986
440
91
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36703180Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum.Brain2023
38017580Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants.Mol Neurodegener2023
37794492Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.Genome Med2023
36790009Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease.Alzheimers Dement2023
36464806Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits.Alzheimers Dement2023
36349119Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.Brain Commun2022
35550177Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.Mol Neurodegener2022
35475137Genome- and epigenome-wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk.Alzheimers Dement (Amst)2022
35346299Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.Mol Neurodegener2022
35698882Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.Alzheimers Dement2022
35571963Effects of age, amyloid, sex, and <i>APOE</i> ε4 on the CSF proteome in normal cognition.Alzheimers Dement (Amst)2022
35386118Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset.Front Aging Neurosci2022
36694577Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.Brain Commun2022
36523958Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks.Front Aging Neurosci2022
36329114Glycosylated clusterin species facilitate Aβ toxicity in human neurons.Sci Rep2022
33422142Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.Alzheimers Res Ther2021
33795014Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice.Alzheimers Res Ther2021
33491853The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease.Alzheimers Dement2021
33792144Replication study of plasma proteins relating to Alzheimer's pathology.Alzheimers Dement2021
34881092Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells.Aging Dis2021
34585227Using Digital Tools to Advance Alzheimer's Drug Trials During a Pandemic: The EU/US CTAD Task Force.J Prev Alzheimers Dis2021
34584936Treatment with TNF-α inhibitors versus methotrexate and the association with dementia and Alzheimer's disease.Alzheimers Dement (N Y)2021
34785643A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.Transl Psychiatry2021
34604499Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.Alzheimers Dement (Amst)2021
34564898Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data.Int J Geriatr Psychiatry2021
34449748CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals.Proteomes2021
34829839Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.Biomedicines2021
34366831Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies.Front Aging Neurosci2021
33285634ANMerge: A Comprehensive and Accessible Alzheimer's Disease Patient-Level Dataset.J Alzheimers Dis2021
33367863Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.Rheumatology (Oxford)2021
32252806Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study.Alzheimers Res Ther2020
31758815Will We Have a Drug for Alzheimer's Disease by 2030? The View From Pharma.Clin Pharmacol Ther2020
31901293Dysregulated Fc gamma receptor-mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis.Neurobiol Aging2020
31738372Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial.JAMA Neurol2020
33344750Evaluating the Alzheimer's disease data landscape.Alzheimers Dement (N Y)2020
33223526Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset.Transl Psychiatry2020
33303834Urinary metabolic phenotyping for Alzheimer's disease.Sci Rep2020
33439986Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics.Brain2020
33173883Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.medRxiv2020
33007638The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study.Med Image Anal2020
32745807An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.Neurobiol Aging2020
32843907Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice.EPMA J2020
32755048Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.Alzheimers Dement2020
32280029Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics.Neurobiol Aging2020
32138650Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia.BMC Neurosci2020
32460813APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.Alzheimers Res Ther2020
30626432Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration.Acta Neuropathol Commun2019
31872043Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications.Alzheimers Dement (N Y)2019
31890857A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort.Alzheimers Dement (N Y)2019
32313838The European medical information framework: A novel ecosystem for sharing healthcare data across Europe.Learn Health Syst2019
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Collaborators

Andrew Simmons
Institute of Psychiatry, King's College London
Co-authored papers 78
Michael J Owen
Co-authored papers 56
Alison M Goate
Icahn School of Medicine at Mount Sinai
Co-authored papers 35
Richard J B Dobson
Institute of Psychiatry, King's College London
Co-authored papers 33
Michael C O'Donovan
Co-authored papers 32
Peter Holmans
Co-authored papers 31
John C Morris
Washington University School of Medicine
Co-authored papers 24
Michael W Weiner
University of California San Francisco
Co-authored papers 19
Stephen J Newhouse
King's College London
Co-authored papers 19
Michael Gill
Co-authored papers 19
Valentina Escott-Price
Co-authored papers 16
John S K Kauwe
Brigham Young University
Co-authored papers 16
Ronald C Petersen
Mayo Clinic Rochester
Co-authored papers 15
Andrew J Saykin
Indiana University School of Medicine
Co-authored papers 14
Tatiana Foroud
Indiana University School of Medicine
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Carsten Russ
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Marian L Hamshere
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Institute of Human Genetics, University Hospital Bonn
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Declan G M Murphy
King's College London
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Kwangsik Nho
Indiana University School of Medicine
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David A Bennett
Rush University Medical Center
Co-authored papers 11
Robert C Green
Brigham and Women's Hospital, Broad Institute Ariadne Labs and Harvard Medical School
Co-authored papers 10
Shannon L Risacher
Indiana University School of Medicine
Co-authored papers 10
Philip L De Jager
Columbia University Medical Center
Co-authored papers 10
Wolfgang Maier
University Hospital Bonn
Co-authored papers 10
Noel J Buckley
Co-authored papers 10
Yonghong Li
Co-authored papers 10
Charles M Rowland
Co-authored papers 9
Andrew B Singleton
National Institute on Aging
Co-authored papers 9
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