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Author Details

Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
1985
72
36
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37656313The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling.Mol Neurobiol2024
34951618Anion binding to a cationic europium(III) probe enables the first real-time assay of heparan sulfotransferase activity.Org Biomol Chem2022
35425031Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.RSC Adv2022
36074065Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions.J Cell Biol2022
33353664Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of ortho-, meta- and para-cresol.Carbohydr Res2021
32065231Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion.Biochem J2020
31816055Relief of talin autoinhibition triggers a force-independent association with vinculin.J Cell Biol2020
31320064A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation.Carbohydr Polym2019
29934491New tools for carbohydrate sulfation analysis: heparan sulfate 2-<i>O</i>-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.Biochem J2018
29138501Targeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites.Sci Rep2017
28263956SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.Nat Cell Biol2017
29153504Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM.Structure2017
27265849LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.Structure2016
27591855Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold.Protein J2016
27531639CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.FEBS Lett2016
26634421Vinculin controls talin engagement with the actomyosin machinery.Nat Commun2015
25035294S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis.Biochim Biophys Acta2014
23389036RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.J Biol Chem2013
23899565Deubiquitylases from genes to organism.Physiol Rev2013
23897824SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.J Biol Chem2013
23726984Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.J Struct Biol2013
22355150The intracellular Ig fold: a robust protein scaffold for the engineering of molecular recognition.Protein Eng Des Sel2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
22483112Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling.Structure2012
22235127A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.J Biol Chem2012
21130070A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain.Biochim Biophys Acta2011
22001210Structural variability of the ubiquitin specific protease DUSP-UBL double domains.FEBS Lett2011
21110983Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA.J Mol Biol2011
20399778The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.FEBS Lett2010
20947018The Structure of the talin head reveals a novel extended conformation of the FERM domain.Structure2010
20610383Central region of talin has a unique fold that binds vinculin and actin.J Biol Chem2010
20150896Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.EMBO J2010
19297334The structure of an interdomain complex that regulates talin activity.J Biol Chem2009
19858215Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.J Biol Chem2009
19804783The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.J Mol Biol2009
19176533Structural determinants of integrin binding to the talin rod.J Biol Chem2009
18157087The structure of the C-terminal actin-binding domain of talin.EMBO J2008
19636914NMR assignment of the C-terminal actin-binding domain of talin.Biomol NMR Assign2008
18638481Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.J Mol Biol2008
18435928Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4.FEBS Lett2008
16584805Role of vinculin in regulating focal adhesion turnover.Eur J Cell Biol2006
16407302The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.J Biol Chem2006
16460027Structural and dynamic characterization of a vinculin binding site in the talin rod.Biochemistry2006
15632179Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189.J Biol Chem2005
16135522Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.J Biol Chem2005
15642262A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.Structure2005
14561217Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.Biochem J2004
15272303Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.EMBO J2004
15216363A stereodivergent asymmetric approach to difluorinated aldonic acids.Chem Commun (Camb)2004
15128738Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation.J Biol Chem2004
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Collaborators

Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 31
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 12
Alexander P Golovanov
The University of Manchester
Co-authored papers 5
Iain D Campbell
University of Oxford
Co-authored papers 4
Mike P Williamson
The University of Sheffield
Co-authored papers 2
C Jeremy Craven
University of Sheffield
Co-authored papers 2
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Michael R Gryk
University of Illinois
Co-authored papers 1
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 1
Matthew P Crump
University of Bristol
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mark H Ginsberg
University of California
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Michael G Joyce
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Chien Ho
Carnegie Mellon University
Co-authored papers 1
Toshimichi Fujiwara
Institute for Protein Research, Osaka University
Co-authored papers 1
Pei Tang
Sichuan University
Co-authored papers 1
Joern Werner
Co-authored papers 1
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 1
Release 1.2