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Author Details

Mario R Ehlers
Clinical Trials Group
1986
76
33
PMIDPaper TitleJournal TitlePublished Year
31537750Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.Pharmacol Rev2019
30167735Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables.Diabetologia2019
29429979Who let the dogs out? The ever-present threat of autoreactive T cells.Sci Immunol2018
29473705Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics.Pediatr Diabetes2018
28844471Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.Cell Immunol2017
28198767Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs.Transplantation2017
29348821Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy.Oncotarget2017
26225763Immune interventions to preserve β cell function in type 1 diabetes.J Investig Med2016
28664195Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.Sci Immunol2016
26518356Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes.Eur J Immunol2016
27208317Two- and Four-Hour Tests Differ in Capture of C-Peptide Responses to a Mixed Meal in Type 1 Diabetes.Diabetes Care2016
27209482Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial.Clin Ther2016
26718498A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.Diabetes2016
27068279Strategies for clinical trials in type 1 diabetes.J Autoimmun2016
27053235Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial.Diabetologia2016
26193635Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.J Clin Invest2015
26370695Targeting memory T cells in type 1 diabetes.Curr Diab Rep2015
24251641Dose response of continuous subcutaneous infusion of recombinant glucagon-like peptide-1 in combination with metformin and sulphonylurea over 12â¿¿weeks in patients with type 2 diabetes mellitus.Diabetes Obes Metab2014
24983393Targeted immune interventions for type 1 diabetes: not as easy as it looks!Curr Opin Endocrinol Diabetes Obes2014
24795433Restoring the balance: immunotherapeutic combinations for autoimmune disease.Dis Model Mech2014
24854541Immune-modulating effects of alpha-1 antitrypsin.Biol Chem2014
23351021Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design.Clin Exp Pharmacol Physiol2013
24622414Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.Lancet Diabetes Endocrinol2013
24622416Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial.Lancet Diabetes Endocrinol2013
23835333Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders.Diabetes2013
23686914C domain-selective inhibition of angiotensin-converting enzyme.J Renin Angiotensin Aldosterone Syst2013
23405091Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.PLoS One2013
23510726Anti-cytokine therapies in T1D: Concepts and strategies.Clin Immunol2013
22668937Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme.S Afr Med J2012
23804273Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience.Rev Diabet Stud2012
22721971Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.Diabetes2012
21362122Dose response of subcutaneous GLP-1 infusion in patients with type 2 diabetes.Diabetes Obes Metab2011
20477411Pacific biomarkers, inc.Biomark Med2008
16895474Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties.Biol Chem2006
17044798Safety issues associated with the use of angiotensin-converting enzyme inhibitors.Expert Opin Drug Saf2006
15813703The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.Biochem J2005
14751227Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme.Biochem Biophys Res Commun2004
12542396Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.Biochem J2003
14605997Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.Horm Metab Res2003
14668810Ace revisited: a new target for structure-based drug design.Nat Rev Drug Discov2003
12610046Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.Diabetes Care2003
12860201Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium.Peptides2003
12366866Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.BMC Microbiol2002
12372418Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.Biochem Biophys Res Commun2002
11485566Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.Biochem J2001
11322496Recombinant human GHRH(1-44)NH2: clinical utility and therapeutic development program.Endocrine2001
11747437Cleavage of disulfide-bridged stalk domains during shedding of angiotensin-converting enzyme occurs at multiple juxtamembrane sites.Biochemistry2001
10758405CR3: a general purpose adhesion-recognition receptor essential for innate immunity.Microbes Infect2000
10974545The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases.Gene2000
10769174Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.Biochem J2000
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Collaborators

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Co-authored papers 8
Yale University
Co-authored papers 7
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Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 5
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 2
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Co-authored papers 2
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Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 1
Mayo Clinic
Co-authored papers 1
Benaroya Research Institute at Virginia Mason, Institute for Systems Biology, Sage Bionetworks, University of Illinois at Urbana-Champaign
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 1
Benaroya Research Institute at Virginia Mason
Co-authored papers 1