Skip to Main Content

Author Details

Melissa McAlonis-Downes
Ludwig Institute for Cancer Research
2003
29
23
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37996528Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.Nat Neurosci2024
34890975Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.Biomaterials2022
36454749Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of <i>C9orf72</i> disease.Proc Natl Acad Sci U S A2022
34083786Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB.Nat Neurosci2021
34488813Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.Mol Neurodegener2021
32325059ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.Neuron2020
31873312Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS.Nat Med2020
32284607Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.Nat Neurosci2020
30747709Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.Elife2019
31092730An endogenous peptide marker differentiates SOD1 stability and facilitates pharmacodynamic monitoring in SOD1 amyotrophic lateral sclerosis.JCI Insight2019
30344044ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.Neuron2018
28247063Misfolded SOD1 is not a primary component of sporadic ALS.Acta Neuropathol2017
28357566Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Acta Neuropathol2017
27112497Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.Neuron2016
25801706Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.Neuron2015
26621731Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.Proc Natl Acad Sci U S A2015
26108367Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Acta Neuropathol Commun2015
23486940Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis.J Neurosci2013
24170860Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.Proc Natl Acad Sci U S A2013
24170856C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.Proc Natl Acad Sci U S A2013
23382207ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Proc Natl Acad Sci U S A2013
22560226Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.Cell Metab2012
22726834Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.Neuron2012
21779368Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.PLoS One2011
19251638Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.Proc Natl Acad Sci U S A2009
18492803Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.Proc Natl Acad Sci U S A2008
16878173Antisense oligonucleotide therapy for neurodegenerative disease.J Clin Invest2006
16802286Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.Ann Neurol2006
14655997Estrous cycle and ovarian changes in a rat mammary carcinogenesis model after irradiation, tamoxifen chemoprevention, and aging.Comp Med2003
  • 1 - 29 of 29

Recommended Authors

Mathieu Bourdenx
University College London, UK Dementia Research Institute
Career Start Year 2013
Number of shared co-authors 0
Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
Career Start Year 2011
Number of shared co-authors 0
Nima Dolatabadi
The Scripps Research Institute
Career Start Year 2010
Number of shared co-authors 0
Sue-Ann Mok
University of Alberta
Career Start Year 2007
Number of shared co-authors 0
Nicolas Casadei
Institute of Medical Genetics and Applied Genomics, University of Tubingen
Career Start Year 2007
Number of shared co-authors 0
Mary H Wertz
Broad Institute, Picower Institute for Learning and Memory
Career Start Year 2007
Number of shared co-authors 0
Vivek Swarup
David Geffen School of Medicine, University of California los angeles
Career Start Year 2007
Number of shared co-authors 0
Laura Ru??
Department of Pharmaceutical and Pharmacological Sciences
Career Start Year 2007
Number of shared co-authors 0
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Career Start Year 2006
Number of shared co-authors 2
Carolina Ceballos-Diaz
Center for Translational Research in Neurodegenerative Disease, University of Florida
Career Start Year 2006
Number of shared co-authors 0
Merina Varghese
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Career Start Year 2005
Number of shared co-authors 0
Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
Career Start Year 2005
Number of shared co-authors 0
Gaia Skibinski
Center for Systems and Therapeutics, J. David Gladstone Institutes
Career Start Year 1999
Number of shared co-authors 0
Aaron D Gitler
Stanford University School of Medicine
Career Start Year 1999
Number of shared co-authors 1
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Career Start Year 1999
Number of shared co-authors 0
Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Career Start Year 1999
Number of shared co-authors 0
Sami J Barmada
University of Michigan ann arbor
Career Start Year 1997
Number of shared co-authors 0
Mimoun Azzouz
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Career Start Year 1996
Number of shared co-authors 1
Giovanni Manfredi
Brain and Mind Research Institute
Career Start Year 1991
Number of shared co-authors 0
Cathleen Lutz
JAX Center for Precision Genetics
Career Start Year 1990
Number of shared co-authors 0
Eric J Huang
University of California san francisco
Career Start Year 1990
Number of shared co-authors 2
Lisa M Ellerby
Buck Institute for Research on Aging
Career Start Year 1990
Number of shared co-authors 0
William T Dauer
Peter O'Donnell Jr. Brain Institute
Career Start Year 1988
Number of shared co-authors 0
Valina L Dawson
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Career Start Year 1988
Number of shared co-authors 0
Steven Finkbeiner
J. David Gladstone Institutes
Career Start Year 1988
Number of shared co-authors 2
Jonathan D Cooper
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Career Start Year 1987
Number of shared co-authors 2
Ted M Dawson
Johns Hopkins University School of Medicine
Career Start Year 1983
Number of shared co-authors 0
Pamela J Shaw
Sheffield Institute for Translational Neuroscience, University of Sheffield
Career Start Year 1983
Number of shared co-authors 2
Steven M Hersch
Inc. University Avenue
Career Start Year 1980
Number of shared co-authors 0
Virginia M-Y Lee
Perelman School of Medicine at the University of Pennsylvania
Career Start Year 1977
Number of shared co-authors 0

Collaborators

Ying Sun
Co-authored papers 4
Leonard Petrucelli
Co-authored papers 3
Gene W Yeo
University of California
Co-authored papers 3
Tania F Gendron
Co-authored papers 3
Xiang-Dong Fu
Co-authored papers 3
James D Berry
Sean M Healey & AMG Center for ALS, Massachusetts General Hospital
Co-authored papers 1
Michael Hu
University of California San Diego
Co-authored papers 1
Alysson R Muotri
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Co-authored papers 1
Jon D Larson
NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Laura Ferraiuolo
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 1
Amy E Taylor
Co-authored papers 1
Robert J Wechsler-Reya
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Scott R VandenBerg
University of California san francisco
Co-authored papers 1
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 1
Daniella McDonald
University of California San Diego
Co-authored papers 1
Kyle Ford
University of California San Diego
Co-authored papers 1
Xin Yi Lei
University of California San Diego
Co-authored papers 1
Thomas D Glenn
Howard Hughes Medical Institute and Salk Institute for Biological Studies
Co-authored papers 1
Jessica M Rusert
University of California San Diego
Co-authored papers 1
Krystal Mach
University of California San Diego
Co-authored papers 1
Huilin Zhou
Co-authored papers 1
Lawrence S B Goldstein
university of california san diego
Co-authored papers 1
Release 1.2