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Author Details

Michael Prakesch
Ontario Institute for Cancer Research, University Avenue
2001
24
12
PMIDPaper TitleJournal TitlePublished Year
36793435Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS Med Chem Lett2023
34963044Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma".J Med Chem2022
34291633Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.J Med Chem2021
34589290The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.Oncoimmunology2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
32295120Sorafenib as an Inhibitor of RUVBL2.Biomolecules2020
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
32778845Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol2020
26952093PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.J Transl Med2016
25164867Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.Nat Commun2014
22329959Size reduction of CdSe/ZnS quantum dots by a peptidic amyloid supergelator.ACS Appl Mater Interfaces2012
22700489Use of kinase inhibitors to correct οF508-CFTR function.Mol Cell Proteomics2012
21303981Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.Cancer Res2011
19249849Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.Chem Rev2009
19146410Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.J Comb Chem2009
18419163Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures.J Comb Chem2008
18835181Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.Bioorg Med Chem2008
18603434The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1.Bioorg Med Chem2008
16961410Part 1. modular approach to obtaining diverse tetrahydroquinoline-derived polycyclic skeletons for use in high-throughput generation of natural-product-like chemical probes.J Comb Chem2006
16961411Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes.J Comb Chem2006
16961412Part 3. a novel stereocontrolled, in situ, solution- and solid-phase, Aza Michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.J Comb Chem2006
14639650Stereoselectivity of nitrile oxide cycloadditions to chiral allylic fluorides: experiment and theory.Chemistry2003
11900521The propargylic route as a short and versatile entry to optically active monofluorinated compounds.Acc Chem Res2002
11325281Synthesis of new optically active propargylic fluorides and application to the enantioselective synthesis of monofluorinated analogues of fatty acid metabolites.J Org Chem2001
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Collaborators

Ontario Institute for Cancer Research, University Avenue
Co-authored papers 11
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 11
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 8
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 6
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 5
University of Perugia
Co-authored papers 4
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 3
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 2
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
University Health Network, University of Toronto
Co-authored papers 2
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.
Co-authored papers 1
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 1
The Hospital for Sick Children Research Institute
Co-authored papers 1
Ontario Institute for Cancer Research, University of Toronto
Co-authored papers 1
University of California los angeles
Co-authored papers 1
Hospital for Sick Children
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
University of Toronto
Co-authored papers 1
Hospital for Sick Children, University of Toronto
Co-authored papers 1
Mount Sinai Hospital
Co-authored papers 1
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 1
Mount Sinai Hospital and Laboratory Medicine and Pathobiology, University of Toronto
Co-authored papers 1
University of Toronto
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1