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Author Details

Dik van Leenen
Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University
1994
45
28
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
28681971Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation.J Orthop Res2018
29440168FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression.Cancer Res2018
27979920Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters.EMBO J2017
28416598EBV MicroRNA BART16 Suppresses Type I IFN Signaling.J Immunol2017
26797113An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF.Sci Rep2016
25990325FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).Biochem J2015
26700642A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.BMC Biol2015
24886914The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression.PLoS One2014
24766815Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.Cell2014
24952590Cell cycle population effects in perturbation studies.Mol Syst Biol2014
23360510Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.Arthritis Res Ther2013
24324601The role of Ctk1 kinase in termination of small non-coding RNAs.PLoS One2013
24141283Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.Nat Commun2013
23936488Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog.PLoS One2013
23785440Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.PLoS One2013
23451256Aberrant gene expression in dogs with portosystemic shunts.PLoS One2013
23472125Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.PLoS One2013
23545502Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.Cell Rep2013
22697265Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis.BMC Genomics2012
23185333Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases.PLoS One2012
23028359Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription.PLoS Genet2012
21596317The specificity and topology of chromatin interaction pathways in yeast.Mol Cell2011
22069189Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.Development2011
20382427Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system.Mol Immunol2010
21145464Functional overlap and regulatory links shape genetic interactions between signaling pathways.Cell2010
20620961A consensus of core protein complex compositions for Saccharomyces cerevisiae.Mol Cell2010
19401678Adaptable gene-specific dye bias correction for two-channel DNA microarrays.Mol Syst Biol2009
19648934Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.Nat Chem Biol2009
18180247Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification.Nucleic Acids Res2008
18462483cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype.Anim Genet2008
17156469Dissection of a metastatic gene expression signature into distinct components.Genome Biol2006
16109375Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.Mol Cell2005
15837421Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit.Mol Cell2005
14695532Twenty-two novel mutations in the lysosomal alpha-glucosidase gene (GAA) underscore the genotype-phenotype correlation in glycogen storage disease type II.Hum Mutat2004
15007037Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment.Hypertension2004
12776180Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.EMBO Rep2003
12671682Monitoring global messenger RNA changes in externally controlled microarray experiments.EMBO Rep2003
11746158Significantly higher number of fetal cells in the maternal circulation of women with pre-eclampsia.Prenat Diagn2001
11015701How useful is the in vitro expansion of fetal CD34+ progenitor cells from maternal blood samples for diagnostic purposes?Prenat Diagn2000
10547605Pathological features of glycogen storage disease type II highlighted in the knockout mouse model.J Pathol1999
12086444A Low-Cost Computerized System to Monitor Running Performance and Circadian Rhythms of Twenty Mice Simultaneously.Contemp Top Lab Anim Sci1999
10217146Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.Nature1999
9660056Glycogen storage disease type II: identification of a dinucleotide deletion and a common missense mutation in the lysosomal alpha-glucosidase gene.Clin Genet1998
9425285Mutation detection in glycogen storage-disease type II by RT-PCR and automated sequencing.Biochem Biophys Res Commun1997
7801313[Warning: sedatives for pets, effect on their master].Tijdschr Diergeneeskd1994
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Collaborators

Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 32
Marian J A Groot Koerkamp
Princess Maxima Center for Pediatric Oncology Research
Co-authored papers 21
Patrick Kemmeren
Princess Maxima Center for Pediatric Oncology
Co-authored papers 12
Philip Lijnzaad
Princess Maxima Center for Pediatric Oncology
Co-authored papers 11
Nathalie Brabers
University Medical Centre Utrecht, Universiteitsweg
Co-authored papers 8
Sander R van Hooff
Princess Maxima Center for Pediatric Oncology
Co-authored papers 8
Thanasis Margaritis
Princess Maxima Center for Pediatric Oncology
Co-authored papers 7
Joris J Benschop
Center for Molecular Medicine, University Medical Center Utrecht
Co-authored papers 7
Mariel O Brok
Princess Maxima Center for Pediatric Oncology
Co-authored papers 7
Tineke L Lenstra
the Netherlands Cancer Institute, Oncode Institute
Co-authored papers 6
Eva Apweiler
University Medical Centre Utrecht, Universiteitsweg
Co-authored papers 5
Katrin Sameith
Center for Molecular and Cellular Bioengineering
Co-authored papers 5
Loes A L van de Pasch
University Medical Centre Utrecht, Universiteitsweg
Co-authored papers 5
Linda V Bakker
Wageningen University and Research
Co-authored papers 4
Harm van Bakel
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Cheuk W Ko
University Medical Centre Utrecht, Universiteitsweg
Co-authored papers 3
Sake van Wageningen
Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 3
Antony J Miles
University Medical Centre Utrecht, Universiteitsweg
Co-authored papers 3
Berend Snel
Utrecht University
Co-authored papers 3
Marijana Radonjic
Top Institute Food and Nutrition
Co-authored papers 3
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Lars M Steinmetz
Stanford University
Co-authored papers 1
Marc van de Wetering
Princess Maxima Center for Pediatric Oncology
Co-authored papers 1
Catherine Dargemont
Institute of Human Genetics, UMR 9002 CNRS - University of Montpellier
Co-authored papers 1
Ines J de Castro
MRC London Institute for Medical Sciences
Co-authored papers 1
Virginia Taliadouros
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Like Fokkens
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Release 1.2