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Author Details

Richard Marcellus
Ontario Institute for Cancer Research, University Avenue
1990
47
26
PMIDPaper TitleJournal TitlePublished Year
36793435Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS Med Chem Lett2023
36948210Discovery of Nanomolar DCAF1 Small Molecule Ligands.J Med Chem2023
34963044Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma".J Med Chem2022
36030052G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.J Biol Chem2022
34291633Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.J Med Chem2021
33542074Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.Clin Cancer Res2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
34301934Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.Nat Commun2021
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
31322299Benchmarking to the Gold Standard: Hyaluronan-Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture.Adv Mater2019
26852132Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.Breast Cancer Res2016
27618721Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.Stem Cell Reports2016
27449082Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.Oncotarget2016
26958703Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).J Med Chem2016
26167872Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
26379026Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
25136132(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.Proc Natl Acad Sci U S A2014
22795084An allosteric inhibitor of protein arginine methyltransferase 3.Structure2012
23250418Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.Nat Commun2012
21047956Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.J Virol2011
21771790Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.J Biol Chem2011
20572251An RNA aptamer that selectively inhibits the enzymatic activity of protein tyrosine phosphatase 1B in vitro.Chembiochem2010
18955965The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells.Oncogene2009
19703994The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.Mol Cell Biol2009
19535438The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.J Virol2009
18040043Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.Proc Natl Acad Sci U S A2007
16122426Proapoptotic BID is an ATM effector in the DNA-damage response.Cell2005
12519725BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.J Biol Chem2003
12668660Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.J Cell Biol2003
11971188Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.Oncogene2002
10933694Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.J Virol2000
10547702Viruses and apoptosis.Annu Rev Microbiol1999
10321733RBP1 induces growth arrest by repression of E2F-dependent transcription.Oncogene1999
9882328Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5.J Virol1999
9696808The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.J Virol1998
9456323E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk.J Cell Biol1998
9094626Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4.J Virol1997
9094654Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.J Virol1997
8764048Importance of the Ser-132 phosphorylation site in cell transformation and apoptosis induced by the adenovirus type 5 E1A protein.J Virol1996
8959332Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein.Cell Growth Differ1996
8709247Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis.J Virol1996
8468552Role of phosphorylation near the amino terminus of adenovirus type 5 early region 1A proteins.J Gen Virol1993
8319767High membrane-associated protein kinase C activity correlates to tumorigenicity but not anchorage-independence in a clone of mouse NIH 3T3 cells.Exp Cell Res1993
1297336Quantitative analysis of regions of adenovirus E1A products involved in interactions with cellular proteins.Biochem Cell Biol1992
1654439Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.J Virol1991
1648699Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation.Oncogene1991
2169695Transforming signals generated by the polyoma virus tumor antigens.Adv Enzyme Regul1990
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Collaborators

Ontario Institute for Cancer Research, University Avenue
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Co-authored papers 10
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Co-authored papers 9
University of Toronto
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Co-authored papers 5
University of Toronto, College St
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Co-authored papers 4
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Co-authored papers 3
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Co-authored papers 2
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
University of Edinburgh
Co-authored papers 2
University Health Network, University of Toronto
Co-authored papers 2
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 2
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
the Second Hospital, Cheeloo College of Medicine, Shandong University
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
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Co-authored papers 1
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Co-authored papers 1
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Princess Margaret Cancer Centre
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University of Edinburgh
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The Hospital for Sick Children Research Institute
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Institute for Research in Immunology and Cancer, Universite de Montreal
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