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Author Details

Richard A Miller
University of Michigan School of Medicine ann arbor
1978
340
70
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37653270Proteomic changes induced by longevity-promoting interventions in mice.Geroscience2024
35974129Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice.Geroscience2023
37481675Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers.Commun Biol2023
37694163Aging Rate Indicators: Speedometers for Aging Research in Mice.Aging Biol2023
37418003PTEN is both an activator and a substrate of chaperone-mediated autophagy.J Cell Biol2023
37315291LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice.Aging (Albany NY)2023
37406767Canagliflozin shares common mTOR and MAPK signaling mechanisms with other lifespan extension treatments.Life Sci2023
37273159Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice.Geroscience2023
37269831Distinct longevity mechanisms across and within species and their association with aging.Cell2023
37166526Long-term effects of canagliflozin treatment on the skeleton of aged UM-HET3 mice.Geroscience2023
36924940Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges.Ageing Res Rev2023
36920743Four anti-aging drugs and calorie-restricted diet produce parallel effects in fat, brain, muscle, macrophages, and plasma of young mice.Geroscience2023
36542300Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.Geroscience2023
3430965717-α-Estradiol Has Sex-Specific Effects on Neuroinflammation That Are Partly Reversed by Gonadectomy.J Gerontol A Biol Sci Med Sci2022
35704312Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice.FASEB J2022
35580607Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation.Cell Metab2022
36525360Lifespan extension in female mice by early, transient exposure to adult female olfactory cues.Elife2022
36179270Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.Aging Cell2022
36173858Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.Science2022
35930768Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice.Aging Cell2022
35014607Aging is associated with increased brain iron through cortex-derived hepcidin expression.Elife2022
35282433Early Life Interventions Can Shape Aging.Front Endocrinol (Lausanne)2022
35305083Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice.Aging (Albany NY)2022
35105357Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation.Immun Ageing2022
34704522Lysosomal targetomics of <i>ghr KO</i> mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes.Autophagy2022
34448851Canagliflozin Increases Intestinal Adenoma Burden in Female ApcMin/+ Mice.J Gerontol A Biol Sci Med Sci2022
32013718Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.Autophagy2021
33742521Cap-independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α-estradiol.Aging Cell2021
33771926CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Proc Natl Acad Sci U S A2021
34851167<i>Muribaculaceae</i> Genomes Assembled from Metagenomes Suggest Genetic Drivers of Differential Response to Acarbose Treatment in Mice.mSphere2021
34552269Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.Nat Metab2021
33988501A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.Elife2021
30864661Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.J Gerontol A Biol Sci Med Sci2020
33145977Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.Aging Cell2020
33068417signatureSearch: environment for gene expression signature searching and functional interpretation.Nucleic Acids Res2020
32990683Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology.JCI Insight2020
32990681Canagliflozin extends life span in genetically heterogeneous male but not female mice.JCI Insight2020
33008901High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.Sci Adv2020
32464603Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.Aging (Albany NY)2020
30688027Acarbose improves health and lifespan in aging HET3 mice.Aging Cell2019
31357177Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice.J Mol Endocrinol2019
31381889Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice.Mech Ageing Dev2019
31353263Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.Cell Metab2019
31423721Improved mitochondrial stress response in long-lived Snell dwarf mice.Aging Cell2019
31195972Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice.BMC Microbiol2019
30924297mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.Aging Cell2019
3074087217-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males.Aging Cell2019
30916479Glycine supplementation extends lifespan of male and female mice.Aging Cell2019
30937823Cellular energetics and mitochondrial uncoupling in canine aging.Geroscience2019
29486228Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.Exp Gerontol2018
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Collaborators

Co-authored papers 7
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University of California San Diego
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National Cancer Institute, National Institutes of Health
Co-authored papers 4
Yale University School of Medicine
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Institute on Aging, University of Florida
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University of Rochester
Co-authored papers 3
Broad Institute of MIT and Harvard
Co-authored papers 3
Institute for Integrative Genome Biology, University of California Riverside
Co-authored papers 2
Oregon Health & Science University
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Mayo Clinic
Co-authored papers 2
University of California davis
Co-authored papers 2
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University
Co-authored papers 2
Co-authored papers 2
University of Tennessee Health Science Center
Co-authored papers 2
University of Washington
Co-authored papers 2
Institute for Systems Biology
Co-authored papers 2
School of Public Health, Oregon Health & Science University-Portland State University
Co-authored papers 2
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University of California San Diego
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Buck Institute for Research on Aging
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