Author details

Full Name

Jeffrey A Kiefer

Affiliation

ORCID

Career Start Year

1999

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35164780	Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas.	Mol Cancer	2022
35247517	Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases.	Pharmacology and Therapeutics	2022
33826614	Identifying treatment options for BRAFV600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial.	PLoS One	2021
34290053	A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.	Sci Transl Med	2021
31369690	Gene ontology analysis of arthrogryposis (multiple congenital contractures).	American Journal of Medical Genetics, Part C: Seminars in Medical Genetics	2019
31881020	Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.	PLoS One	2019
30700832	Isolation and characterization of patient-derived CNS metastasis-associated stromal cell lines.	Oncogene	2019
29440177	Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.	Clin Cancer Res	2018
30188888	Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.	PLoS Genet	2018
30042785	Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients.	Front Genet	2018
28212541	Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses.	Oncotarget	2017
28586388	A prospective pilot study of genome-wide exome and transcriptome profiling in patients with small cell lung cancer progressing after first-line therapy.	PLoS One	2017
28373299	Integrated genomic analyses reveal frequent <i>TERT</i> aberrations in acral melanoma.	Genome Res	2017
28617226	Contextualization of drug-mediator relations using evidence networks.	BMC Bioinformatics	2017
29435161	Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis.	Oncotarget	2017
27897001	DIFFERENTIAL PATHWAY DEPENDENCY DISCOVERY ASSOCIATED WITH DRUG RESPONSE ACROSS CANCER CELL LINES.	Pac Symp Biocomput	2017
27932423	Integrated genomic analysis of survival outliers in glioblastoma.	Neuro Oncol	2017
27587986	Arthrogryposis as a Syndrome: Gene Ontology Analysis.	Molecular Syndromology	2016
26776171	KNOWLEDGE-ASSISTED APPROACH TO IDENTIFY PATHWAYS WITH DIFFERENTIAL DEPENDENCIES.	Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing	2016
26189820	microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C.	Liver Int	2016
27936176	Correction: Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy.	PLoS One	2016
26063764	Pilot Trial of Selecting Molecularly Guided Therapy for Patients with Non-V600 BRAF-Mutant Metastatic Melanoma: Experience of the SU2C/MRA Melanoma Dream Team.	Mol Cancer Ther	2015
25802883	Personalized treatment of SÃ©zary syndrome by targeting a novel CTLA4:CD28 fusion.	Mol Genet Genomic Med	2015
25790323	Review of X-linked syndromes with arthrogryposis or early contractures-aid to diagnosis and pathway identification.	Am J Med Genet A	2015
25940539	Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.	Oncotarget	2015
25934816	Toward precision medicine in glioblastoma: the promise and the challenges.	Neuro Oncol	2015
26275879	Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis.	Eukaryotic Cell	2015
24658001	Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4.	Nat Genet	2014
24489661	Integrated genomic and epigenomic analysis of breast cancer brain metastasis.	PLoS One	2014
23171949	Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities.	Mol Cancer Ther	2013
22859646	The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.	Journal of the American Medical Informatics Association : JAMIA	2013
23772300	Elucidating potentially significant genomic regions involved in the initiation and progression of undifferentiated pleomorphic sarcoma.	Rare Tumors	2013
24204837	Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy.	PLoS One	2013
24204627	A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges.	PLoS One	2013
23418942	Learning contextual gene set interaction networks of cancer with condition specificity.	BMC Genomics	2013
22100984	Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors.	Biochemical Pharmacology	2012
22315651	Molecular Characterization of a Patient's Small Cell Carcinoma of the Ovary of the Hypercalcemic Type.	Journal of Cancer	2012
23196986	Genomic analysis and selected molecular pathways in rare cancers.	Physical Biology	2012
23071490	Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.	PLoS One	2012
22156929	Preclinical investigation of nanoparticle albumin-bound paclitaxel as a potential treatment for adrenocortical cancer.	Ann Surg	2012
21730190	Advancing a clinically relevant perspective of the clonal nature of cancer.	Proceedings of the National Academy of Sciences of the United States of America	2011
21480251	Genomic signatures of cancer: basis for individualized risk assessment, selective staging and therapy.	Journal of Surgical Oncology	2011
21294127	Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer.	Journal of Pathology	2011
20469965	A high-content RNAi-screening assay to identify modulators of cholesterol accumulation in Niemann-Pick type C cells.	Assay and Drug Development Technologies	2010
19597791	High-throughput siRNA screening as a method of perturbation of biological systems and identification of targeted pathways coupled with compound screening.	Methods in Molecular Biology	2009
19519883	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Journal of Translational Medicine	2009
18452169	Functional evidence implicating S100P in prostate cancer progression.	Int J Cancer	2008
19956181	Using biointelligence to search the cancer genome: an epistemological perspective on knowledge recovery strategies to enable precision medical genomics.	Oncogene	2008
18330920	Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.	Hum Mutat	2008
17332642	Validation of short interfering RNA knockdowns by quantitative real-time PCR.	Methods in Molecular Biology	2007