Author details

Full Name

Saghi Ghaffari

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36473018	Haematopoietic stem cell quiescence exposed using mitochondrial membrane potential.	Current Opinion in Hematology	2023
37672319	Elevated CDKN1A (P21) mediates Î²-thalassemia erythroid apoptosis, but its loss does not improve Î²-thalassemic erythropoiesis.		2023
36595934	Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging.		2022
35908627	Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes.	Experimental Hematology	2022
33710339	Using mitochondrial activity to select for potent human hematopoietic stem cells.	Blood advances	2021
34226904	Mild anemia as a single independent predictor of mortality in patients with COVID-19.		2021
33837966	Red cell distribution width is associated with mortality in non-anemic patients with COVID-19.	Journal of Medical Virology	2021
33667358	Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy.		2021
34032849	Mitochondrial localization and moderated activity are key to murine erythroid enucleation.	Blood advances	2021
33440185	Erythroid enucleation: a gateway into a "bloody" world.	Experimental Hematology	2021
32109377	Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.	Cell Stem Cell	2020
30808633	Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities.	Blood	2019
30252956	Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.	American Journal of Hematology	2019
30414157	Following Transcriptome to Uncover FOXO Biological Functions.	Methods in Molecular Biology	2019
29782339	Transcription factors FOXO in the regulation of homeostatic hematopoiesis.	Current Opinion in Hematology	2018
30518851	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.	Nature Communications	2018
29433741	Preface.	Current Topics in Developmental Biology	2018
29433739	Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm.	Current Topics in Developmental Biology	2018
27994057	FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage.	J Biol Chem	2017
28639090	Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination.	Journal of Bioenergetics and Biomembranes	2017
26610678	Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis.	Matrix Biology	2016
27442953	Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease.	British Journal of Haematology	2016
26929388	Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells.	Cell Cycle	2016
26452208	A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.	PLoS Genet	2015
26343536	CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation.	Nat Immunol	2015
26209246	Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3.	EMBO Reports	2015
25068121	Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.	Stem Cell Reports	2014
25371358	Stem cells and the impact of ROS signaling.	Development (Cambridge)	2014
23975182	Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.	Haematologica	2014
24383555	Stem cells, redox signaling, and stem cell aging.	Antioxidants and Redox Signaling	2014
24421322	PIAS adds methyl-bias to HSC-differentiation.	EMBO Journal	2014
25163926	Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity.	American Journal of Hematology	2014
25115889	The exosome complex establishes a barricade to erythroid maturation.	Blood	2014
24966026	FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.	American Journal of Hematology	2014
23502961	Macrophages support pathological erythropoiesis in polycythemia vera and Î²-thalassemia.	Nature Medicine	2013
22480644	[FoxO proteins in the control of stem cells].	Medecine/Sciences	2012
22162726	Cancer, stem cells and cancer stem cells: old ideas, new developments.	F1000 Medicine Reports	2011
21443463	Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned?	Current Drug Targets	2011
21804543	FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.	Nature Cell Biology	2011
20679398	miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.	Genes and Development	2010
21113129	ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice.	EMBO Journal	2010
19650689	Oxidative stress regulation of stem and progenitor cells.	Antioxidants and Redox Signaling	2009
19679564	Stra13 regulates oxidative stress mediated skeletal muscle degeneration.	Human Molecular Genetics	2009
18707226	Oxidative stress in the regulation of normal and neoplastic hematopoiesis.	Antioxidants and Redox Signaling	2008
18424439	Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.	Journal of Biological Chemistry	2008
17671650	Foxo3 is required for the regulation of oxidative stress in erythropoiesis.	Journal of Clinical Investigation	2007
23641148	bHLH-Orange Transcription Factors in Development and Cancer.	Translational Oncogenomics	2007
16254141	AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.	Blood	2006
16204311	Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway.	Blood	2006
12644574	Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning.	Mol Cell Proteomics	2003