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Author Details

James R Woodgett
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
1982
311
111
PMIDPaper TitleJournal TitlePublished Year
36779422Interactomes of Glycogen Synthase Kinase-3 Isoforms.J Proteome Res2023
37707557GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion.J Mol Med (Berl)2023
37463901Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer.Nat Commun2023
34812500Cardiomyocyte-GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms.J Cell Physiol2022
35544541Multicenter international assessment of a SARS-CoV-2 RT-LAMP test for point of care clinical application.PLoS One2022
35641396Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells.J Dermatol Sci2022
35782378Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus.Front Mol Neurosci2022
36052698Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.Circ Res2022
34001180Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods.Virol J2021
33609145Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice.J Mol Med (Berl)2021
34400288GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson's disease.Neurosci Lett2021
34475389Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.Nat Commun2021
32581704GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib.Front Mol Neurosci2020
31785335Emerging roles of GSK-3α in pathophysiology: Emphasis on cardio-metabolic disorders.Biochim Biophys Acta Mol Cell Res2020
32813289Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.FASEB J2020
30928428Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.J Mol Cell Cardiol2019
31671858A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells.Cells2019
31836816Molecular stratification within triple-negative breast cancer subtypes.Sci Rep2019
31825015Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.FASEB Bioadv2019
32337479Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations.JNCI Cancer Spectr2019
32337478Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions.JNCI Cancer Spectr2019
32328559Who Actually Funds Cancer Research?JNCI Cancer Spectr2019
30704524A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling.Breast Cancer Res2019
31112656How to continually make the case for fundamental science: from the perspective of a protein kinase.Biochem Cell Biol2019
29203592Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.FASEB J2018
30210653Polypharmacological Profiles Underlying the Antitumor Property of <i>Salvia miltiorrhiza</i> Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps.Oxid Med Cell Longev2018
29856958A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.Cell2018
29474906A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.Cell2018
29617654Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.Cell Rep2018
29385396Isoform-specific requirement for GSK3α in sperm for male fertility.Biol Reprod2018
29382851Gimap5-dependent inactivation of GSK3β is required for CD4<sup>+</sup> T cell homeostasis and prevention of immune pathology.Nat Commun2018
29074359Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells.Toxicol Appl Pharmacol2017
28114292Gsk3 is a metabolic checkpoint regulator in B cells.Nat Immunol2017
28299185Recent advances in understanding the cellular roles of GSK-3.F1000Res2017
28098160A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.Sci Rep2017
28236969Glycogen Synthase Kinase 3: A Kinase for All Pathways?Curr Top Dev Biol2017
29109121Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.J Immunol2017
26755559Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.Mol Cell Biol2016
27693132Enabling the Next 25 Years of Cell Biology.Trends Cell Biol2016
27825099Regulation of the protein kinase activity of ShaggyZeste-white3 by components of the Wingless pathway in Drosophila cells and embryos.J Biol Chem2016
27501329Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.Nat Cell Biol2016
27321043Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin.Biochem Pharmacol2016
26976650Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.Circ Res2016
25195860Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.Oncogene2015
26400062Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.Cancer Res2015
26100021Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway.Mol Cell Biol2015
25629553Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease.Kidney Int2015
25552693The GSK-3 family as therapeutic target for myocardial diseases.Circ Res2015
25608967Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.Am J Physiol Renal Physiol2015
24604594Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway.J Cell Physiol2014
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Collaborators

Bradley W Doble
Co-authored papers 21
Tony Hunter
Salk Institute for Biological Studies
Co-authored papers 8
Eldad Zacksenhaus
University of Toronto
Co-authored papers 7
Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Gordon B Mills
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 5
Brent W Zanke
University of Toronto
Co-authored papers 5
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 5
Tony Pawson
Co-authored papers 4
Patryk Skowron
University of Toronto
Co-authored papers 4
Xi He
Boston Children's Hospital, Harvard Medical School
Co-authored papers 4
Walter J Koch
Co-authored papers 4
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 4
Rod Bremner
University of Toronto
Co-authored papers 4
Dong-Yu Wang
College of Pharmaceutical Sciences, Shanghai Jiao Tong University
Co-authored papers 4
John C Roder
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 4
Fei-Fei Liu
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 3
Zhe Jiang
Toronto General Research Institute, University Health Network, 67 College Street
Co-authored papers 3
Tatiana V Lipina
Institute of Neurosciences and Medicine
Co-authored papers 3
Livia Garzia
The Research Institute of the McGill University Health Centre, McGill University
Co-authored papers 3
Kenneth Aldape
National Cancer Institute
Co-authored papers 3
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 2
Priscilla K Brastianos
Co-authored papers 2
Noriyuki Kijima
Osaka University Graduate School of Medicine
Co-authored papers 2
Uri Tabori
Co-authored papers 2
Daniel W Fults
Co-authored papers 2
Betty Luu
University of Wollongong
Co-authored papers 2
Marshall Alan Permutt
Washington University School of Medicine
Co-authored papers 2
Antonio C Wolff
Co-authored papers 2
Cynthia Hawkins
The Hospital for Sick Children
Co-authored papers 2
Tony Mazzulli
Mount Sinai Health System and University Health Network
Co-authored papers 2
Release 1.2