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Author Details

David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
1990
264
137
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37292894An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.bioRxiv2023
34706266GCN2 adapts protein synthesis to scavenging-dependent growth.Cell Syst2022
35771919Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.Science2022
35831510Structure of the nutrient-sensing hub GATOR2.Nature2022
35859173Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.Nature2022
36409067Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.Elife2022
36104569Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.Nature2022
36100671Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.Nature2022
36131016CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.Nature2022
35017686Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity.Nature2022
34135321Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.Nat Commun2021
33651980CRISPR screens in physiologic medium reveal conditionally essential genes in human cells.Cell Metab2021
33483422Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.Proc Natl Acad Sci U S A2021
33658354<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia.Sci Transl Med2021
34855504Fumarate is a terminal electron acceptor in the mammalian electron transport chain.Science2021
34607910mTOR-Activating Mutations in <i>RRAGD</i> Are Causative for Kidney Tubulopathy and Cardiomyopathy.J Am Soc Nephrol2021
32375022A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.Cell Metab2020
31937935mTOR at the nexus of nutrition, growth, ageing and disease.Nat Rev Mol Cell Biol2020
31996837Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.Nat Med2020
31959991A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.Nat Med2020
32005970Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease.Nat Rev Mol Cell Biol2020
31649036Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.J Exp Med2020
33087354MCART1/SLC25A51 is required for mitochondrial NAD transport.Sci Adv2020
33208952MFSD12 mediates the import of cysteine into melanosomes and lysosomes.Nature2020
33148642Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.Sci Adv2020
32719541Dihydroxyacetone phosphate signals glucose availability to mTORC1.Nat Metab2020
32571778Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.Cancer Discov2020
32704543Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition.Sci Adv2020
32694612Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.Sci Rep2020
32214253Dietary modifications for enhanced cancer therapy.Nature2020
32111721Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.J Biol Chem2020
32434850<i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone.Sci Transl Med2020
32405003Author Correction: Tumours with PI3K activation are resistant to dietary restriction.Nature2020
32268298Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.Aging (Albany NY)2020
30541894MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.Proc Natl Acad Sci U S A2019
31704029Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.Cell2019
31722960Nutrient regulation of mTORC1 at a glance.J Cell Sci2019
32694817The next decade of metabolism.Nat Metab2019
29969188DEPTOR modulates activation responses in CD4<sup>+</sup> T cells and enhances immunoregulation following transplantation.Am J Transplant2019
31292548Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.Nature2019
31601764Architecture of human Rag GTPase heterodimers and their complex with mTORC1.Science2019
31601708Structural basis for the docking of mTORC1 on the lysosomal surface.Science2019
31314152C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.FEBS Open Bio2019
31019072Genome-wide CRISPR screen for Zika virus resistance in human neural cells.Proc Natl Acad Sci U S A2019
31072927Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.Proc Natl Acad Sci U S A2019
30760928Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.Nature2019
30651352Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.J Biol Chem2019
30542996Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines.Methods Mol Biol2019
29274432A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.Neurobiol Dis2018
29995852Histidine catabolism is a major determinant of methotrexate sensitivity.Nature2018
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Harvard Medical School
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Clary B Clish
Broad Institute of MIT and Harvard
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Norbert Perrimon
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University of Texas Southwestern Medical Center
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Matthew Meyerson
Broad Institute
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Barbara A Weir
Janssen Research and Development LLC
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Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 3
Roxanne K Barrow
Co-authored papers 3
Choah Kim
Co-authored papers 3
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 3
Polina Golland
Massachusetts Institute of Technology
Co-authored papers 3
Tyler Jacks
Co-authored papers 3
Serena J Silver
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Release 1.2