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Author Details

Christine Guthrie
University of California san francisco
1967
165
74
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
31927482Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.iScience2020
30674666Prp8 impacts cryptic but not alternative splicing frequency.Proc Natl Acad Sci U S A2019
29487104Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.RNA2018
30133335Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.Mol Biol Cell2018
30021831Identification of the Novel <i>Nup188-brr7</i> Allele in a Screen for Cold-Sensitive mRNA Export Mutants in <i>Saccharomyces cerevisiae</i>.G3 (Bethesda)2018
28416677Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.Proc Natl Acad Sci U S A2017
28132896Genetics and biochemistry remain essential in the structural era of the spliceosome.Methods2017
28446597The histone variant H2A.Z promotes splicing of weak introns.Genes Dev2017
26968627Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.RNA2016
27528618The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.Mol Cell Biol2016
27072132Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.J Biol Chem2016
26931416A new communication hub in the RNA world.Nat Struct Mol Biol2016
25780103Present at the creation.RNA2015
26694144Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.PLoS Genet2015
26167880SR protein kinases promote splicing of nonconsensus introns.Nat Struct Mol Biol2015
25825871Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast.PLoS Genet2015
24231520An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.RNA2014
24842270Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations.Bioessays2014
24717535Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate.RNA Biol2014
24681967The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.RNA2014
24476359H2B ubiquitylation modulates spliceosome assembly and function in budding yeast.Biol Cell2014
24011056Colony PCR.Methods Enzymol2013
24182917Yeast-gene replacement using PCR products.Methods Enzymol2013
24240612Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing.Nat Struct Mol Biol2013
23932120From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.Cell2013
24011057Chemical transformation of yeast.Methods Enzymol2013
22681890Hierarchical modularity and the evolution of genetic interactomes across species.Mol Cell2012
23209445The yeast SR-like protein Npl3 links chromatin modification to mRNA processing.PLoS Genet2012
22479208Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit.PLoS Genet2012
21697354Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast.RNA2011
21632821Regulation of the Dbp5 ATPase cycle in mRNP remodeling at the nuclear pore: a lively new paradigm for DEAD-box proteins.Genes Dev2011
19880518From the ribosome to the spliceosome and back again.J Biol Chem2010
21057525Reciprocal intronic and exonic histone modification regions in humans.Nat Struct Mol Biol2010
21051641Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss.Science2010
20580958Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast.Methods Enzymol2010
20305654Conformational dynamics of single pre-mRNA molecules during in vitro splicing.Nat Struct Mol Biol2010
19239896SnapShot: Formation of mRNPs.Cell2009
19328059Getting to the gate: crystallization of a Sac3(CID):Sus1:Cdc31 complex.Mol Cell2009
19525970Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2.Nat Struct Mol Biol2009
19098916ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.Nat Struct Mol Biol2009
18391019Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation.Mol Cell Biol2008
19061648A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.Mol Cell2008
19061647A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast.Mol Cell2008
18461042Modifications target spliceosome dynamics.Nat Struct Mol Biol2008
17194212Alternative 3' pre-mRNA processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1 in vivo.PLoS Biol2007
17956975Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.RNA2007
17889666Rapid, transcript-specific changes in splicing in response to environmental stress.Mol Cell2007
17388687Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components.PLoS Biol2007
17351132Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans.Genome Res2007
16618971Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA.RNA2006
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Collaborators

University of California San Francisco
Co-authored papers 10
University of Dundee
Co-authored papers 9
University of California san francisco
Co-authored papers 6
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 6
Innovative Genomics Institute, University of California berkeley
Co-authored papers 6
The College of New Jersey
Co-authored papers 5
Wellcome Trust Sanger Institute
Co-authored papers 5
Institut de Genetique Moleculaire de Montpellier, CNRS
Co-authored papers 5
University of California San Francisco
Co-authored papers 4
Texas A&M University School of Medicine
Co-authored papers 4
University College Dublin
Co-authored papers 4
Washington and Lee University
Co-authored papers 4
Harvard Medical School
Co-authored papers 4
Inc. Lexington
Co-authored papers 3
University of Colorado Boulder
Co-authored papers 3
University of California san francisco
Co-authored papers 3
University of California davis
Co-authored papers 2
School of Public Health, Guangdong Medical University
Co-authored papers 2
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Research Institute of Molecular Pathology (IMP)
Co-authored papers 2
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 2
Fudan University
Co-authored papers 1
Co-authored papers 1
1University of Maryland School of Pharmacy
Co-authored papers 1
University College Dublin (UCD) School of Computer Science, University College Dublin
Co-authored papers 1
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Co-authored papers 1
University of California san francisco
Co-authored papers 1