Author details

Full Name

Charles Lee

Affiliation

ORCID

Career Start Year

2000

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34224879	Mako: A Graph-based Pattern Growth Approach to Detect Complex Structural Variants.	Genomics Proteomics Bioinformatics	2022
34559564	Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor.	Sci Adv	2021
33760063	muCNV: Genotyping Structural Variants for Population-level Sequencing.	Bioinformatics	2021
29633279	Biological explanations for discordant noninvasive prenatal test results: Preliminary data and lessons learned.	Prenat Diagn	2018
27503198	Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.	Clin Cancer Res	2017
28198030	Confined placental mosaicism for 22q11.2 deletion as the etiology for discordant positive NIPT results.	Prenatal Diagnosis	2017
26829649	Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR.	Nat Neurosci	2016
24613413	Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.	Cancer Cell	2014
25279985	Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders.	Am J Hum Genet	2014
23656838	Copy number variation genotyping using family information.	BMC Bioinformatics	2013
23887156	ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas.	Am J Surg Pathol	2013
24014587	Primate genome architecture influences structural variation mechanisms and functional consequences.	Proc Natl Acad Sci U S A	2013
24009521	Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.	PLoS Genet	2013
23593015	Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.	PLoS Genet	2013
23517041	Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility.	Clin Exp Allergy	2013
23663786	Diverse mechanisms of somatic structural variations in human cancer genomes.	Cell	2013
22203992	Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis.	Proc Natl Acad Sci U S A	2012
22797897	Regulatory element copy number differences shape primate expression profiles.	Proc Natl Acad Sci U S A	2012
22745640	Genomic amplification of an endogenous retrovirus in zebrafish T-cell malignancies.	Advances in Hematology	2012
22745252	Landscape of somatic retrotransposition in human cancers.	Science	2012
22388000	Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration.	Nat Genet	2012
22425996	A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.	Nature	2012
22632962	Tumor archaeology reveals that mutations love company.	Cell	2012
22496589	Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.	Proc Natl Acad Sci U S A	2012
22483647	Exploring the role of copy number variants in human adaptation.	Trends in Genetics	2012
21735374	Reporting of diagnostic cytogenetic results.	Current Protocols in Human Genetics	2011
21293372	Mapping copy number variation by population-scale genome sequencing.	Nature	2011
21504705	Genomic alterations in myeloid neoplasms with novel, apparently balanced translocations.	Cancer Genet	2011
21924167	Molecular cytogenetic methodologies and a BAC probe panel resource for genomic analyses in the zebrafish.	Methods in Cell Biology	2011
21627829	Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.	Genome Biol	2011
21552289	Shared acquired genomic changes in zebrafish and human T-ALL.	Oncogene	2011
20056642	Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.	Cancer Epidemiol Biomarkers Prev	2010
20842731	Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma.	Genes Chromosomes and Cancer	2010
20812997	Comparison of familial and sporadic chronic lymphocytic leukaemia using high resolution array comparative genomic hybridization.	Br J Haematol	2010
20891028	Reporting of diagnostic cytogenetic results.	Current Protocols in Human Genetics	2010
20572109	The future of prenatal cytogenetic diagnostics: a personal perspective.	Prenatal Diagnosis	2010
20129249	Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.	Cancer Cell	2010
20472851	EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry.	Am J Clin Pathol	2010
20466091	Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.	Am J Hum Genet	2010
20118985	Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.	Oncogene	2010
18822366	Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis.	Genomics	2009
19545629	Copy number variants (CNVs) in primate species using array-based comparative genomic hybridization.	Methods	2009
19156837	Distinct genomic aberrations associated with ERG rearranged prostate cancer.	Genes Chromosomes Cancer	2009
19704007	Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.	Mol Cell Biol	2009
18973135	Construction and application of a zebrafish array comparative genomic hybridization platform.	Genes Chromosomes Cancer	2009
18594010	EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.	Clin Cancer Res	2008
17512202	Fluorescence-based detection of short DNA sequences under non-denaturing conditions.	Bioorganic and Medicinal Chemistry	2008
18304495	The fine-scale and complex architecture of human copy-number variation.	Am J Hum Genet	2008
18228561	On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.	Genet Epidemiol	2008
18180252	Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies.	Hum Mol Genet	2008