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Author Details

Gregory S Yochum
The Pennsylvania State University College of Medicine
1998
71
25
PMIDPaper TitleJournal TitlePublished Year
37776721Disease Severity Impairs Generation of Intestinal Organoid Cultures From Inflammatory Bowel Disease Patients.J Surg Res2024
36113570Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts.Gastroenterology2023
37663924Pyoderma Gangrenosum Is Associated With Increased Risk of Inflammatory Pouch-Related Complications: A Retrospective Cohort Study.Crohns Colitis 3602023
37696579Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity.Life Sci Alliance2023
37873177Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway.bioRxiv2023
37393618Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways.Cell Rep2023
37156770Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.Nat Commun2023
37378558Creating a Surgical Biobank: The Hershey Medical Center Experience.Dis Colon Rectum2023
37034132Molecular genetics of early-onset colorectal cancer.World J Biol Chem2023
36856684The Microbiome of Complicated Diverticulitis: An Imbalance of Sulfur-Metabolizing Bacteria.Dis Colon Rectum2023
36833408TCF7L1 Regulates <i>LGR5</i> Expression in Colorectal Cancer Cells.Genes (Basel)2023
36757365Correction: Dichotomous role of the human mitochondrial Na<sup>+</sup>/Ca2<sup>+</sup>/Li<sup>+</sup> exchanger NCLX in colorectal cancer growth and metastasis.Elife2023
36322638Long-Term Use of Proton Pump Inhibitors Disrupts Intestinal Tight Junction Barrier and Exaggerates Experimental Colitis.J Crohns Colitis2023
36219473Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.J Crohns Colitis2023
34964704AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability.Autophagy2022
36139061Transcriptome Analyses Identify Deregulated <i>MYC</i> in Early Onset Colorectal Cancer.Biomolecules2022
31714311Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease.Ann Surg2021
33506258Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease.J Crohns Colitis2021
34561473PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression.Sci Rep2021
34256195CD163L1<sup>+</sup>CXCL10<sup>+</sup> Macrophages are Enriched Within Colonic Lamina Propria of Diverticulitis Patients.J Surg Res2021
34225052COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon.J Surg Res2021
31633754Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn's disease and regulate Th1/Th17 cell responses.Int Immunol2020
32045400Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy.Dis Colon Rectum2020
32866088Transcriptomic analysis of ileal tissue from Crohn's disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis.Physiol Genomics2020
32385106The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.J Biol Chem2020
32569770IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.Gastroenterology2020
30511196Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics.Dig Dis Sci2019
31826065Elevated Colonic Mucin Expression Correlates with Extended Time to Surgery for Ulcerative Colitis Patients.J Gastrointestin Liver Dis2019
31595002Tristetraprolin targets Nos2 expression in the colonic epithelium.Sci Rep2019
30794691The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells.PLoS One2019
30671539Synthetic Cannabinoid Activity Against Colorectal Cancer Cells.Cannabis Cannabinoid Res2018
30240468A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients.J Gastrointestin Liver Dis2018
29846097Pathophysiology of diverticular disease.Expert Rev Gastroenterol Hepatol2018
28633443NOD2 Genetic Variants Predispose One of Two Familial Adenomatous Polyposis Siblings to Pouchitis Through Microbiome Dysbiosis.J Crohns Colitis2017
28450117TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells.Biochem Biophys Res Commun2017
28985852Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia.J Surg Res2017
28814777The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients.Sci Rep2017
28595269Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.Hum Mol Genet2017
28594959Reduced total serum bilirubin levels are associated with ulcerative colitis.PLoS One2017
28619727RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.Am J Physiol Gastrointest Liver Physiol2017
27223305The MYC 3' Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells.Cancers (Basel)2016
26320084A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice.Dig Dis Sci2016
26639180Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia.Leukemia2016
27554912Review article: the pathogenesis of pouchitis.Aliment Pharmacol Ther2016
25659031A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.Cell Cycle2015
26629312Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer.World J Biol Chem2015
24299953Nuclear AXIN2 represses MYC gene expression.Biochem Biophys Res Commun2014
24567369The myc 3' wnt-responsive element suppresses colonic tumorigenesis.Mol Cell Biol2014
24667606Targeted repression of AXIN2 and MYC gene expression using designer TALEs.Biochem Biophys Res Commun2014
23027379Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways.Acta Biochim Biophys Sin (Shanghai)2013
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Collaborators

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Nationwide Children's Hospital
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Co-authored papers 7
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Co-authored papers 7
Ryan Cleland
Co-authored papers 4
Soren Impey
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Co-authored papers 3
Yuka Imamura Kawasawa
Co-authored papers 3
Scott J Emrich
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Co-authored papers 3
Sean R McCorkle
Brookhaven National Laboratory
Co-authored papers 2
Sydney L Kyler
Co-authored papers 2
Mary MacPartlin
Oregon Health and Science University
Co-authored papers 2
Gail Mandel
Vollum Institute, Oregon Health and Science University
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John J Dunn
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Veena Rajaraman
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Hyunjoo Cha-Molstad
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Brian J Druker
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Jami Dwyer
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Raji Pillai
Jawaharlal Institute of Post-graduate Medical Education and Research
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Alexander Rialdi
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Marc M Loriaux
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Qunhua Li
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Lucy C Pemberton
Southern District Health Board, Dunedin Hospital
Co-authored papers 1
Hidekazu Tsukamoto
University of Michigan ann arbor
Co-authored papers 1
Beth Wilmot
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Michael G Rosenfeld
University of California San Diego
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Junia V Melo
University of Adelaide
Co-authored papers 1
Yibu Chen
USC Libraries Bioinformatic Services of the University of Southern California
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Release 1.2