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Author Details

Tarjei S Mikkelsen
Harvard University, USA Broad Institute, USA Harvard Stem Cell Institute
2001
78
56
PMIDPaper TitleJournal TitlePublished Year
34004179Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification.Cell Stem Cell2021
32231336Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.Nat Biotechnol2020
33238290Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.Nature2020
32743583Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures.bioRxiv2020
31515224Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression.Development2019
30079747Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays.Am J Respir Crit Care Med2019
29367672Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.Nat Commun2018
30195438Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome.Cell Syst2018
30385546Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.Science2018
29474912Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Cell2018
28007941Registry in a tube: multiplexed pools of retrievable parts for genetic design space exploration.Nucleic Acids Res2017
28388432Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.Cell Stem Cell2017
28137873Systematic dissection of genomic features determining transcription factor binding and enhancer function.Proc Natl Acad Sci U S A2017
28100691Registry in a tube: multiplexed pools of retrievable parts for genetic design space exploration.Nucleic Acids Res2017
28467820Non-equivalence of Wnt and R-spondin ligands during Lgr5<sup>+</sup> intestinal stem-cell self-renewal.Nature2017
28091601Massively parallel digital transcriptional profiling of single cells.Nat Commun2017
28942919Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues.Cell2017
29061959Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.Nat Commun2017
28686870Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.Cell Stem Cell2017
27078102A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Proc Natl Acad Sci U S A2016
27701403Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions.Nat Biotechnol2016
27760319Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.Cell Rep2016
27749844Prospective functional classification of all possible missense variants in PPARG.Nat Genet2016
27259154Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits.Cell2016
27259153Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Cell2016
27320042LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.Cell Stem Cell2016
27211859Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.Cell Syst2016
25533951Dissecting neural differentiation regulatory networks through epigenetic footprinting.Nature2015
26186193Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.Cell2015
25503565Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Nat Cell Biol2015
24063364microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN.Stem Cells Dev2014
25521328Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation.PLoS Genet2014
25403361Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples.Genome Biol2014
24981863Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.Cell Rep2014
25177895Massively parallel reporter assays in cultured mammalian cells.J Vis Exp2014
24816923Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.PLoS One2014
24898411The regulatory landscape of osteogenic differentiation.Stem Cells2014
24914046Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes.Nucleic Acids Res2014
24714595ZBED6 modulates the transcription of myogenic genes in mouse myoblast cells.PLoS One2014
24658644The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells.Nat Biotechnol2014
24449344Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells.Stem Cells2014
23512712Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.Genome Res2013
24269006High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.Cell2013
24174531Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.J Biol Chem2013
23791531Cellular source and mechanisms of high transcriptome complexity in the mammalian testis.Cell Rep2013
23414147Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells.BMC Genomics2013
22371084Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.Nat Biotechnol2012
23249739Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.Genes Dev2012
22899817Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.BMC Genomics2012
22521691Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO.Mol Cell2012
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Collaborators

Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 26
Bradley E Bernstein
Broad Institute of MIT and Harvard
Co-authored papers 11
Andreas Gnirke
The Center for Genome Architecture, Baylor College of Medicine
Co-authored papers 11
Alexander Meissner
Co-authored papers 11
Manolis Kellis
Massachusetts Institute of Technology
Co-authored papers 8
Chad Nusbaum
Co-authored papers 6
Hongcang Gu
Co-authored papers 6
John L Rinn
Co-authored papers 6
Manuel Garber
Co-authored papers 5
Pardis C Sabeti
Harvard University
Co-authored papers 5
David B Jaffe
Co-authored papers 5
Kerstin Lindblad-Toh
Uppsala University
Co-authored papers 5
Evan D Rosen
Co-authored papers 5
Michael C Zody
Broad Institute of Harvard and MIT
Co-authored papers 5
Jean L Chang
Co-authored papers 4
Bruce W Birren
Broad Institute of MIT and Harvard
Co-authored papers 4
Aviv Regev
Broad Institute of MIT and Harvard
Co-authored papers 4
Stephen F Schaffner
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 4
Zachary D Smith
University of Maryland Baltimore County
Co-authored papers 4
Ryan Tewhey
University of Maine
Co-authored papers 4
Jennifer Hall
Co-authored papers 3
Charles B Epstein
Co-authored papers 3
Toby Bloom
Co-authored papers 3
Marco A Marra
University of British Columbia
Co-authored papers 3
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 3
Andrew Zimmer
Co-authored papers 3
Chris P Ponting
The University of Edinburgh
Co-authored papers 3
David DeCaprio
Broad Institute of Harvard and MIT
Co-authored papers 3
Michele Clamp
Harvard University
Co-authored papers 3
Jason Ernst
Co-authored papers 3
Release 1.2