Author details

Full Name

Guy A Rutter

Affiliation

ORCID

Career Start Year

1987

Papers

365

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36980244	ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.		2023
38076935	Differential CpG methylation at in the early establishment of beta cell heterogeneity.		2023
37284792	Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing.		2023
37025411	Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome - A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern India.		2023
37396167	Impact of an loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice.		2023
37137910	Identification of biomarkers for glycaemic deterioration in type 2 diabetes.	Nat Commun	2023
37134170	Divergent acute versus prolonged pharmacological GLP-1R responses in adult Î² cell-specific Î²-arrestin 2 knockout mice.		2023
36694809	A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing.		2023
36529987	New-onset type 1 diabetes and severe acute respiratory syndrome coronavirus 2 infection.		2023
37502937	Multiple genetic variants at the locus affect local super-enhancer activity and influence pancreatic Î²-cell survival and function.		2023
37488322	Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell.		2023
34363458	Mechanisms of Weight Loss After Obesity Surgery.	Endocrine Reviews	2022
35398277	Autotaxin signaling facilitates Î² cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency.	Molecular Metabolism	2022
36246869	Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice.	Frontiers in Endocrinology	2022
35594379	Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney.		2022
35681432	Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.	Cells	2022
36134336	Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.	iScience	2022
35676825	In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.	Diabetes, Obesity and Metabolism	2022
35476777	Glucose-Dependent miR-125b Is a Negative Regulator of Î²-Cell Function.		2022
35472764	Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated Î²-Cell Connectivity and Insulin Secretion.		2022
35597240	DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism.	Developmental Cell	2022
35294578	Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase.	Diabetologia	2022
35254894	Destabilization of Î² Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.	Proceedings of the National Academy of Sciences of the United States of America	2022
35017316	Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death.	J Endocrinol	2022
34376475	Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.	Diabetes	2021
33492421	Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.	Diabetologia	2021
34129856	Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.	Biochem Pharmacol	2021
34285239	Author Correction: PDX1<sup>LOW</sup> MAFA<sup>LOW</sup> Î²-cells contribute to islet function and insulin release.	Nat Commun	2021
33960419	The Ca -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.	FEBS Letters	2021
34110439	Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.	Diabetologia	2021
33730570	Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.	Cell Reports	2021
33514698	PDX1<sup>LOW</sup> MAFA<sup>LOW</sup> Î²-cells contribute to islet function and insulin release.	Nat Commun	2021
33989778	Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated Î²-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.	Molecular Metabolism	2021
34193609	Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis.	Science Translational Medicine	2021
33763030	Consequences for Pancreatic Î²-Cell Identity and Function of Unregulated Transcript Processing.	Frontiers in Endocrinology	2021
33498234	Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link?	International Journal of Molecular Sciences	2021
33087457	Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.		2021
33068125	Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice.	Diabetologia	2021
33268378	Genetic and biased agonist-mediated reductions in Î²-arrestin recruitment prolong cAMP signaling at glucagon family receptors.	Journal of Biological Chemistry	2021
35046906	Editorial: Pancreas Imaging Across the Spectrum.	Frontiers in Endocrinology	2021
34453049	Intravital imaging of islet Ca dynamics reveals enhanced Î² cell connectivity after bariatric surgery in mice.	Nature Communications	2021
34491913	Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice.	J Clin Invest	2021
34545099	Author Correction: Intravital imaging of islet Ca dynamics reveals enhanced Î² cell connectivity after bariatric surgery in mice.	Nature Communications	2021
31419404	Metabolic and Functional Heterogeneity in Pancreatic Î² Cells.	Journal of Molecular Biology	2020
32416313	The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.	Mol Metab	2020
32122411	Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction.	Br J Nutr	2020
32350566	The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.	Diabetologia	2020
32296773	The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists.	ACS Pharmacol Transl Sci	2020
32229720	Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release.	JCI insight	2020
32278079	Disconnect between signalling potency and inÂ vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists.	Molecular Metabolism	2020