Author details

Full Name

Muniswamy Madesh

Affiliation

ORCID

Career Start Year

1996

Papers

176

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292659	Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis.		2023
38007529	Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis.		2023
36824758	The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes.		2023
36754568	The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity.		2023
36754446	Modulation of the mitochondrial Ca<sup>2+</sup> uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells.	Physiol Rep	2023
37006181	Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca signalling.		2023
36857182	Limiting Mrs2-dependent mitochondrial Mg uptake induces metabolic programming in prolonged dietary stress.		2023
37547075	Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways inÂ the Heart.		2023
35005527	SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.	iScience	2022
36476944	The mitochondrial Ca uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca oscillations.		2022
34494107	MCU-complex-mediated mitochondrial calcium signaling is impaired in Barth syndrome.	Human Molecular Genetics	2022
34816101	Resolving macrophage polarization through distinct Ca entry channel that maintains intracellular signaling and mitochondrial bioenergetics.	iScience	2021
34118180	Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.	Aging Cell	2021
33450506	BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca-dependent mPTP opening.	Cell Calcium	2021
33713581	Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase-3.	Physiological Reports	2021
33359401	Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease.	Molecular Metabolism	2021
33296287	Molecular nature and physiological role of the mitochondrial calcium uniporter channel.	American Journal of Physiology - Cell Physiology	2021
34450540	Emergence of repurposed drugs as modulators of MCU channel for clinical therapeutics.	Cell Calcium	2021
34666498	Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.	J Am Heart Assoc	2021
32851774	MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer.	EMBO Rep	2020
32312983	Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy.	Cell Death and Disease	2020
32101699	MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.	Cell Chem Biol	2020
31931281	xCT (SLC7A11) expression confers intrinsic resistance to physical plasma treatment in tumor cells.	Redox Biology	2020
32277051	Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.	J Biol Chem	2020
33103015	Regulation of Ca exchanges and signaling in mitochondria.	Current Opinion in Physiology	2020
32601238	An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter.	Proc Natl Acad Sci U S A	2020
33035451	Lactate Elicits ER-Mitochondrial Mg Dynamics to Integrate Cellular Metabolism.	Cell	2020
32978391	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism.	Nat Commun	2020
32956070	Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis.	JCI insight	2020
31393858	Dual peroxisome-proliferator-activated-receptor-Î±/Î³ activation inhibits SIRT1-PGC1Î± axis and causes cardiac dysfunction.	JCI Insight	2019
31594854	The Ca export pump PMCA clears near-membrane Ca to facilitate store-operated Ca entry and NFAT activation.	Science Signaling	2019
30256393	Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.	Journal of Cellular Physiology	2019
30637731	Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.	Journal of Cellular Physiology	2019
30611795	Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.	Journal of Molecular and Cellular Cardiology	2019
31230251	Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.	Breast Cancer Research and Treatment	2019
30696938	Impaired non-homologous end joining in human primary alveolar type II cells in emphysema.	Scientific Reports	2019
30917323	Blockade of MCU-Mediated Ca<sup>2+</sup> Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.	Cell Rep	2019
30693334	A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.	ACS Central Science	2019
31383554	Mitochondrial dysfunction in human primary alveolar type II cells in emphysema.	eBioMedicine	2019
31313618	The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2019
31313616	The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2019
31310854	Complex I and II are required for normal mitochondrial Ca homeostasis.	Mitochondrion	2019
29733576	pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance.	ACS applied materials & interfaces	2018
28493473	Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.	Journal of Cellular Physiology	2018
29980025	Molecular regulation of MCU: Implications in physiology and disease.	Cell Calcium	2018
30158529	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.	Nature Communications	2018
30020827	The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation.	American Journal of Physiology - Cell Physiology	2018
30301883	Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism.	Cell Death and Disease	2018
30140897	Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.	JAMA Cardiol	2018
29476075	The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema.	Scientific Reports	2018