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Author Details

Anne Marinier
Institute for Research in Immunology and Cancer
1997
44
20
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37097827Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen.ACS Chem Biol2023
34731885Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Blood Adv2022
35797243HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.Blood Adv2022
35729784Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.J Med Chem2022
35589701Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.Nat Commun2022
33417871UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell2021
34705497Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.Sci Adv2021
34344896Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.Nat Commun2021
31300747Genetic characterization of ABT-199 sensitivity in human AML.Leukemia2020
31704264Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Lancet Haematol2020
33214838Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.ACS Med Chem Lett2020
30267280Diagnostic Accuracy of Procalcitonin for Early Aspiration Pneumonia in Critically Ill Patients with Coma: A Prospective Study.Neurocrit Care2019
31246024Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.J Med Chem2019
31460098Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.ACS Omega2019
31287994Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.Cancer Cell2019
31510684Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.Bioinformatics2019
30940883Identification of Allosteric Inhibitors against Active Caspase-6.Sci Rep2019
30883143Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.Org Lett2019
30782614Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.Blood Adv2019
29550835Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.Leukemia2018
28053157Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.Sci Transl Med2017
28211886A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.Blood Cancer J2017
28855357Chemogenomic Landscape of <i>RUNX1</i>-mutated AML Reveals Importance of <i>RUNX1</i> Allele Dosage in Genetics and Glucocorticoid Sensitivity.Clin Cancer Res2017
27034432Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.Blood2016
27797342High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.J Clin Invest2016
27874094Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.Sci Rep2016
25437913Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.Nat Struct Mol Biol2015
26237430The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.Nat Genet2015
24492100[Acute myeloid leukemia with t(8;21): unusual cytological presentation and immunophenotype].Ann Biol Clin (Paris)2014
25237102Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.Science2014
24562423Identification of small molecules that support human leukemia stem cell activity ex vivo.Nat Methods2014
24316736E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.Nat Chem Biol2014
23029226Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.PLoS One2012
19267461Novel tricyclic inhibitors of IkappaB kinase.J Med Chem2009
15869878Biaryl isoxazolinone antibacterial agents.Bioorg Med Chem Lett2005
15319780Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.EMBO Rep2004
15324898Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.Bioorg Med Chem Lett2004
12668003Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.Bioorg Med Chem Lett2003
12565963Sordaricin antifungal agents.Bioorg Med Chem Lett2003
11408160Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.Bioorg Med Chem2001
11751388Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).Cancer Res2001
9452473Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes.J Biol Chem1998
9379443Sulfated galactocerebrosides as potential antiinflammatory agents.J Med Chem1997
9316838BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.J Pharmacol Exp Ther1997
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Collaborators

Guy Sauvageau
Universite de Montreal
Co-authored papers 16
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Universite de Montreal
Co-authored papers 11
Jana Krosl
The Leucegene Project at Institute for Research in Immunology and Cancer.
Co-authored papers 10
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Institute for Research in Immunology and Cancer, Universite de Montreal
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Dana-Farber Cancer Institute
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Sylvain Meloche
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Co-authored papers 3
Patrick Gendron
University of Montreal
Co-authored papers 3
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Universite de Montreal
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Universite de Montreal, Institute for Research in Immunology and Cancer
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IRIC - University of Montreal
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Trang Hoang
Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University
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Peter W Zandstra
Co-authored papers 2
Diogo F T Veiga
University of Campinas (UNICAMP)
Co-authored papers 2
Mathieu Tremblay
Universite de Montreal, Institute for Research in Immunology and Cancer
Co-authored papers 2
Veronique Litalien
Walter and Eliza Hall Institute of Medical Research
Co-authored papers 1
Bastien Gerby
Universite de Toulouse, Inserm, Universite Toulouse III-Paul Sabatier
Co-authored papers 1
Genevi??ve Lavoie
Institute for Research in Immunology and Cancer (IRIC)
Co-authored papers 1
Milena Kosic
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Release 1.2