Author details

Full Name

Pamela J Shaw

Affiliation

Sheffield Institute for Translational Neuroscience, University of Sheffield

ORCID

Career Start Year

1983

Papers

470

H Index

Expertise

CM4AI Collaborator

Nevan J Krogan (CM4AI)

PMID	Paper Title	Journal Title	Published Year
35871544	Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.	Brain Pathol	2023
37828541	Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis.	Transl Neurodegener	2023
35852375	Comparison Of King's Clinical Staging In Multinational Amyotrophic Lateral Sclerosis Cohorts.	Amyotroph Lateral Scler Frontotemporal Degener	2023
37251807	A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.	Front Aging Neurosci	2023
37043475	Genetic variability in sporadic amyotrophic lateral sclerosis.	Brain	2023
37477391	Combining electromyography and Raman spectroscopy: optical EMG.	Muscle Nerve	2023
36925053	The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases.	Neurobiol Dis	2023
36857431	A cell-penetrant peptide blocking <i>C9ORF72</i>-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.	Sci Transl Med	2023
36918362	Physical activity as an exogenous risk factor for amyotrophic lateral sclerosis: a review of the evidence.	Brain	2023
36543887	Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.	Nat Rev Drug Discov	2023
36688084	Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy: A magnetic resonance spectroscopy study.	Front Pain Res (Lausanne)	2023
36509983	Analysis of brain and spinal MRI measures in a common domain to investigate directional neurodegeneration in motor neuron disease.	J Neurol	2023
36937187	Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival.	Front Cell Neurosci	2023
36481799	Prospects for gene replacement therapies in amyotrophic lateral sclerosis.	Nat Rev Neurol	2023
34322948	Assessment of the Precision in Measuring Glutathione at 3â¿¿T With a MEGA-PRESS Sequence in Primary Motor Cortex and Occipital Cortex.	J Magn Reson Imaging	2022
35614165	Creatine kinase and prognosis in amyotrophic lateral sclerosis: a literature review and multi-centre cohort analysis.	J Neurol	2022
35441136	Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis.	Brain Commun	2022
35545877	Rapid identification of human muscle disease with fibre optic Raman spectroscopy.	Analyst	2022
35406750	Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes.	Cells	2022
35762576	Fiber optic Raman spectroscopy for the evaluation of disease state in Duchenne muscular dystrophy: An assessment using the mdx model and human muscle.	Muscle Nerve	2022
35569295	Tensor electrical impedance myography identifies bulbar disease progression in amyotrophic lateral sclerosis	Clin Neurophysiol	2022
36589292	Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data.	Front Cell Neurosci	2022
36619668	Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.	Front Cell Neurosci	2022
36499600	Blood-Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders.	Int J Mol Sci	2022
36497181	Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS.	Cells	2022
36371497	The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.	Nat Commun	2022
36241425	Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.	Life Sci Alliance	2022
36034213	EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes.	iScience	2022
36129998	Trial of Antisense Oligonucleotide Tofersen for <i>SOD1</i> ALS.	N Engl J Med	2022
36380299	A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol.	BMC Neurol	2022
36290620	Dipeptide Repeat Pathology in <i>C9orf72</i>-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance.	Antioxidants (Basel)	2022
36323511	Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis.	Neurol Neuroimmunol Neuroinflamm	2022
36222101	Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis.	Analyst	2022
36116464	Amyotrophic lateral sclerosis.	Lancet	2022
35291294	Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.	bioRxiv	2022
35224491	Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain.	Brain Commun	2022
35313342	SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction.	Hum Mol Genet	2022
34886679	Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries.	Circ Res	2022
35091648	Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis.	NPJ Genom Med	2022
34687220	Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate.	Muscle Nerve	2022
32365404	TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis.	Neuropathol Appl Neurobiol	2021
33869658	Adipose-derived stem cells protect motor neurons and reduce glial activation in both <i>inÂ vitro</i> and <i>inÂ vivo</i> models of ALS.	Mol Ther Methods Clin Dev	2021
33535055	Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene.	Cell Rep	2021
33589474	Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.	J Neurol Neurosurg Psychiatry	2021
34409288	Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2.	Brain Commun	2021
34404845	Extensive phenotypic characterisation of a human TDP-43<sup>Q331K</sup>Â transgenic mouse model of amyotrophic lateral sclerosis (ALS).	Sci Rep	2021
34521070	Tensor electrical impedance myography identifies clinically relevant features in amyotrophic lateral sclerosis.	Physiol Meas	2021
34376242	SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.	Mol Neurodegener	2021
34623437	Membrane lipid raft homeostasis is directly linked to neurodegeneration.	Essays Biochem	2021
34044197	Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.	Neurobiol Aging	2021

1 - 50 of 470

Susan Byrne

Royal College of Surgeons in Ireland

Career Start Year 2010

Number of shared co-authors 1

Laura Ru??

Department of Pharmaceutical and Pharmacological Sciences

Career Start Year 2007

Number of shared co-authors 0

Merina Varghese

Friedman Brain Institute, Icahn School of Medicine at Mount Sinai

Career Start Year 2005

Number of shared co-authors 1

Melissa McAlonis-Downes

Ludwig Institute for Cancer Research

Career Start Year 2003

Number of shared co-authors 2

Giovanni Coppola

David Geffen School of Medicine, University of California los angeles

Career Start Year 1999

Number of shared co-authors 33

Annie Hiniker

University of California, San Diego and VA San Diego Healthcare System (D.G.

Career Start Year 1998

Number of shared co-authors 4

Sami J Barmada

University of Michigan ann arbor

Career Start Year 1997

Number of shared co-authors 5

Stephan Frank

Universitatsspital Basel

Career Start Year 1996

Number of shared co-authors 3

Suman Jayadev

University of Washington

Career Start Year 1995

Number of shared co-authors 21

Kathryn J Swoboda

Center for Genomic Medicine, Massachusetts General Hospital

Career Start Year 1994

Number of shared co-authors 10

Petra Kaufmann

Novartis Gene Therapies

Career Start Year 1994

Number of shared co-authors 6

Ahmet Hoke

Johns Hopkins School of Medicine

Career Start Year 1994

Number of shared co-authors 3

Richard Bedlack

Duke University

Career Start Year 1992

Number of shared co-authors 7

Peter Hedera

University of Louisville

Career Start Year 1992

Number of shared co-authors 2

Yuko Shimizu

Tokyo Women's Medical University School of Medicine

Career Start Year 1992

Number of shared co-authors 0

Sebastian Brandner

UCL Queen Square Institute of Neurology

Career Start Year 1989

Number of shared co-authors 14

William T Dauer

Peter O'Donnell Jr. Brain Institute

Career Start Year 1988

Number of shared co-authors 4

Valina L Dawson

Institute for Cell Engineering, Johns Hopkins University School of Medicine

Career Start Year 1988

Number of shared co-authors 14

Lefkos T Middleton

Ageing Epidemiology Research Unit, School of Public Health, Imperial College London

Career Start Year 1988

Number of shared co-authors 25

Paul E Schulz

The University of Texas Health Science Center at Houston, McGovern Medical School

Career Start Year 1988

Number of shared co-authors 3

Camilo Toro

National Human Genome Research Institute, National Institutes of Health

Career Start Year 1986

Number of shared co-authors 10

Massimo Pandolfo

Universite Libre de Bruxelles (ULB)

Career Start Year 1985

Number of shared co-authors 22

Andrea Martinuzzi

Scientific Institute, IRCCS Eugenio Medea, Conegliano-Pieve di Soligo Research Centre

Career Start Year 1984

Number of shared co-authors 7

Basil T Darras

Boston Children's Hospital, Harvard Medical School

Career Start Year 1983

Number of shared co-authors 6

Ted M Dawson

Johns Hopkins University School of Medicine

Career Start Year 1983

Number of shared co-authors 29

Raymond S Turner

Georgetown University

Career Start Year 1981

Number of shared co-authors 19

Steven M Hersch

Inc. University Avenue

Career Start Year 1980

Number of shared co-authors 6

Enrico Bertini

IRCCS Bambino Gesu Children's Research Hospital

Career Start Year 1978

Number of shared co-authors 19

David G Standaert

University of Alabama at Birmingham

Career Start Year 1977

Number of shared co-authors 11

Lawrence S Honig

University of California

Career Start Year 1975

Number of shared co-authors 45

row(s) 1 - 30 of 30

Jonathan D Cooper