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Author Details

Jaime H Cheah
Johns Hopkins University School of Medicine
2000
33
21
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34369086Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype.Arthritis Care Res (Hoboken)2023
36747859Compressed phenotypic screens for complex multicellular models and high-content assays.bioRxiv2023
36909640Screening in serum-derived medium reveals differential response to compounds targeting metabolism.bioRxiv2023
36804377Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT Network.Am J Pathol2023
35385705Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.Cell Metab2022
35585948Management of scleroderma gastrointestinal disease: Lights and shadows.J Scleroderma Relat Disord2022
35862544Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.Science2022
33536439High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.Nat Commun2021
33767382Computationally guided high-throughput design of self-assembling drug nanoparticles.Nat Nanotechnol2021
32126173Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization.J Org Chem2020
31792422Identification and local delivery of vasodilators for the reduction of ureteral contractions.Nat Biomed Eng2020
31422662Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives.J Am Chem Soc2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
31202980An expanded proteome of cardiac t-tubules.Cardiovasc Pathol2019
29676157A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production.Biochemistry2018
27109210A genetic basis for the variation in the vulnerability of cancer to DNA damage.Nat Commun2016
26656090Correlating chemical sensitivity and basal gene expression reveals mechanism of action.Nat Chem Biol2016
27329820Integrated genetic and pharmacologic interrogation of rare cancers.Nat Commun2016
27128528Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.ACS Chem Biol2016
25501949Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.Cancer Discov2015
26482930Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Cancer Discov2015
26336940Concise Total Synthesis of (+)-Luteoalbusins A and B.Org Lett2015
25860544Discovery of a Small-Molecule Probe for V-ATPase Function.J Am Chem Soc2015
24439385Regulation of ferroptotic cancer cell death by GPX4.Cell2014
25058389NAMPT is the cellular target of STF-31-like small-molecule probes.ACS Chem Biol2014
23426685Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity.J Neurosci2013
23999124PKA modulates iron trafficking in the striatum via small GTPase, Rhes.Neuroscience2013
23993102An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.Cell2013
17504197Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.Med Chem2007
16908409NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1.Neuron2006
15951807S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.Nat Cell Biol2005
15944123S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors.Neuron2005
10944103The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site.EMBO J2000
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Collaborators

Stuart L Schreiber
Broad Institute
Co-authored papers 11
Alykhan F Shamji
Center for the Science of Therapeutics, Broad Institute
Co-authored papers 10
Paul A Clemons
Broad Institute
Co-authored papers 9
Matthew G Rees
Co-authored papers 7
Sangwon F Kim
Co-authored papers 4
Solomon H Snyder
Co-authored papers 4
Vlado Dan????k
Broad Institute
Co-authored papers 3
Ted Liefeld
Moores Cancer Center, University of California San Diego
Co-authored papers 3
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 3
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 3
William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 3
Joshua A Bittker
Co-authored papers 3
Charles W M Roberts
Co-authored papers 2
David E Root
Broad Institute of Harvard and MIT
Co-authored papers 2
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 2
Robert Langer
Co-authored papers 2
Francisca Vazquez
Broad Institute of MIT and Harvard
Co-authored papers 2
Brent R Stockwell
Columbia University
Co-authored papers 2
Gregory V Kryukov
Co-authored papers 2
Benjamin Alexander
Co-authored papers 2
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 2
Markus Warmuth
Co-authored papers 1
Joshua Gould
Co-authored papers 1
Antonio Sorrentino
Leibniz Institute for Immunotherapy (LIT)
Co-authored papers 1
Nicolas Stransky
Co-authored papers 1
Alex H Ramos
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Krishna R Juluri
Co-authored papers 1
Alexandra Corella
Fred Hutchinson Cancer Research Center
Co-authored papers 1
Ramnik J Xavier
Broad Institute of MIT and Harvard
Co-authored papers 1
Release 1.2