Author details

Full Name

Rainer Heuchel

Affiliation

Karolinska Institutet

ORCID

Career Start Year

1988

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36282601	Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis.	Inflamm Bowel Dis	2023
37596278	An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.	Nat Commun	2023
36919330	FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner.	Cancer Res	2023
36224174	Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action.	Signal Transduct Target Ther	2022
36310582	Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer.	iScience	2022
33946033	3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma.	Transl Oncol	2021
35041343	Targeting of Smad7 in Mesenchymal Cells Does Not Exacerbate Fibrosis During Experimental Chronic Pancreatitis.	Pancreas	2021
34746135	Pancreatic Ductal Adenocarcinoma: Preclinical <i>in vitro</i> and <i>ex vivo</i> Models.	Front Cell Dev Biol	2021
34798385	Stabilization of the classical phenotype upon integration of pancreatic cancer cells into the duodenal epithelium.	Neoplasia	2021
33201660	Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents.	ACS Appl Mater Interfaces	2020
33060625	The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity.	Sci Rep	2020
31072019	Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells.	Cancers (Basel)	2019
31380604	Tamoxifen affects chronic pancreatitis-related fibrogenesis in an experimental mouse model: an effect beyond Cre recombination.	FEBS Open Bio	2019
31542399	Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma.	Pancreatology	2019
29633756	Publisher Correction: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.	Nat Commun	2018
30139658	RCAN1 is a marker of oxidative stress, induced in acute pancreatitis.	Pancreatology	2018
28077438	Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.	Gut	2018
28524160	Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC.	Br J Cancer	2017
28413374	Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics.	Metabolomics	2017
28338506	A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.	J Immunother	2017
28161459	Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-GuÃ©rin vaccination.	Int J Infect Dis	2017
28125728	Correction: Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification.	PLoS One	2017
28323815	Retraction: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.	Nat Commun	2017
28675654	Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer.	Mol Oncol	2017
28765528	Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.	Sci Rep	2017
27349482	Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-Î² signaling.	Biochim Biophys Acta	2016
27739427	Editorial Expression of Concern: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.	Nat Commun	2016
27829047	Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification.	PLoS One	2016
25971870	Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.	Scand J Gastroenterol	2015
26378065	Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma.	Clin Chem	2015
26187672	Fluorescence labeled microbubbles for multimodal imaging.	Biochem Biophys Res Commun	2015
24723982	Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.	Theranostics	2014
25337831	Desmoplasia and chemoresistance in pancreatic cancer.	Cancers (Basel)	2014
24736316	Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.	Nat Commun	2014
24862634	Age-dependent and differential effects of Smad7Î¿Ex1 on neural progenitor cell proliferation and on neurogenesis.	Exp Gerontol	2014
23301086	Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-Î²/Smad3-NF.ÎºB-dependent mechanisms in mice.	PLoS One	2013
23894614	Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension.	PLoS One	2013
23994637	Smad7 regulates terminal maturation of chondrocytes in the growth plate.	Dev Biol	2013
23625826	Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.	J Pathol	2013
23446043	3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.	BMC Cancer	2013
20980457	The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential.	Diabetes	2011
22056140	Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.	Cell Stem Cell	2011
22034611	Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-Î².	Pulm Circ	2011
21674029	Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.	PLoS One	2011
19913614	The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.	Matrix Biol	2010
20551902	CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.	EMBO J	2010
20479122	Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner.	Mol Cell Biol	2010
19096081	Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice.	Nephrol Dial Transplant	2009
18266971	Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.	J Cell Mol Med	2008
18762776	A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.	Lab Invest	2008

1 - 50 of 75

Feng Chen

Washington University in St Louis

Career Start Year 2004

Number of shared co-authors 0

Susan L Woods

Adelaide Medical School, University of Adelaide

Career Start Year 2002

Number of shared co-authors 0

Ping Guo

Steadman Philippon Research Institute, Center for Regenerative Sports Medicine

Career Start Year 2001

Number of shared co-authors 1

Qingxia Wei

Princess Margaret Cancer Centre, University Health Network and University of Toronto

Career Start Year 2000

Number of shared co-authors 0

Yaroslav Teper

David Geffen School of Medicine, University of California los angeles

Career Start Year 1999

Number of shared co-authors 0

Val??rie Petit

INSERM U1021, Institut Curie, PSL Research University, Campus Universitaire

Career Start Year 1999

Number of shared co-authors 0

Jianjun Shen

The University of Texas MD Anderson Cancer Center

Career Start Year 1998

Number of shared co-authors 0

Bin Zhou

The Central Hospital of Shaoyang

Career Start Year 1998

Number of shared co-authors 0

Dongquan Chen

University of Alabama at Birmingham

Career Start Year 1997

Number of shared co-authors 0

Andrew J Elia

University Health Network, Princess Margaret Cancer Centre

Career Start Year 1995

Number of shared co-authors 1

Alexander D Borowsky

University of California Davis Health

Career Start Year 1995

Number of shared co-authors 0

Mingyao Liu

The Institute of Biomedical Sciences, East China Normal University

Career Start Year 1994

Number of shared co-authors 0

Keping Xie

The South China University of Technology Comprehensive Cancer Center

Career Start Year 1993

Number of shared co-authors 1

Erwin P Bottinger

Hasso Plattner Institute for Digital Health at Mount Sinai

Career Start Year 1992

Number of shared co-authors 2

Nabeel Bardeesy

Massachusetts General Hospital

Career Start Year 1992

Number of shared co-authors 2

Andrew Wakeham

Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network

Career Start Year 1989

Number of shared co-authors 0

Timothy C Wang

Division of Gastroenterology and Irvine Cancer Research Center, Columbia University

Career Start Year 1988

Number of shared co-authors 1

Enzo Medico

Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS

Career Start Year 1988

Number of shared co-authors 1

Gregory A Michelotti

Inc. Research Triangle Park

Career Start Year 1987

Number of shared co-authors 0

Louis Gaboury

Institute for Research in Immunology and Cancer (IRIC), University of Montreal

Career Start Year 1986

Number of shared co-authors 0

Klaus H Kaestner

Department of Genetics and Institute for Diabetes, University of Pennsylvania

Career Start Year 1986

Number of shared co-authors 0

Hans Clevers

Princess Maxima Center for Pediatric Oncology

Career Start Year 1985

Number of shared co-authors 1

Jeffrey L Wrana

Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital

Career Start Year 1985

Number of shared co-authors 0

Jorge Silvio Gutkind

Moores Cancer Center, University of California San Diego

Career Start Year 1984

Number of shared co-authors 0

Rama Khokha

Princess Margaret Cancer Centre, University Health Network

Career Start Year 1984

Number of shared co-authors 0

Francisco X Real

Spanish National Cancer Research Centre-CNIO

Career Start Year 1983

Number of shared co-authors 0

Michael C Ostrowski

Hollings Cancer Center, Medical University of South Carolina

Career Start Year 1979

Number of shared co-authors 0

Akiko Hata

Cardiovascular Research Institute, University of California san francisco

Career Start Year 1978

Number of shared co-authors 0

Glenn Merlino

Center for Cancer Research, National Cancer Institute, National Institutes of Health

Career Start Year 1978

Number of shared co-authors 0

Bruce J Aronow

Cincinnati Children's Hospital Medical Center

Career Start Year 1975

Number of shared co-authors 2

row(s) 1 - 30 of 30

Marco Del Chiaro

University of Colorado

Co-authored papers 4

Fei He

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Co-authored papers 2

Daniela Hoeller

Institute of Biochemistry II, Goethe University

Co-authored papers 1

Christian Schultz

Mannheim Center for Translational Neuroscience, Heidelberg University

Co-authored papers 1

Wolfgang Wurst

Institute of Developmental Genetics, German Research Center for Environmental Health

Co-authored papers 1

Kaisa Haglund

Institute for Cancer Research, Oslo University Hospital

Co-authored papers 1

Tony Pawson

Co-authored papers 1

Birgit Stein

Co-authored papers 1

Marina Londo??o

Gunma University Graduate School of Medicine

Co-authored papers 1

Peter Jedlicka

Justus Liebig University Giessen

Co-authored papers 1

Mirko H H Schmidt

Institute of Anatomy, Technische Universitat Dresden School of Medicine

Co-authored papers 1

Luc Dirix

GZA Ziekenhuizen Campus Sint-Augustinus, University of Antwerp

Co-authored papers 1

Nicole Ehrhardt

University of Washington

Co-authored papers 1

Johanna S M Mattsson

Uppsala University

Co-authored papers 1

Andreas Brech

Institute for Cancer Research, Oslo University Hospital

Co-authored papers 1

Ioannis P Nezis

University of Warwick

Co-authored papers 1

Johan Lindberg

Karolinska Institute

Co-authored papers 1

Jochen M Schwenk

KTH Royal Institute of Technology

Co-authored papers 1

Chun-Hong Qiu

Shandong University

Co-authored papers 1

Anthony J Iafrate

Massachusetts General Hospital

Co-authored papers 1

Juha Kere

Folkhalsan Research Center, University of Helsinki

Co-authored papers 1

Kristopher K Frese

Cancer Research UK Manchester Institute, University of Manchester

Co-authored papers 1

Jun Ikezawa

Tokyo Metropolitan Neurological Hospital

Co-authored papers 1

Snorri S Thorgeirsson

Co-authored papers 1

Vladimir Kirkin

the Institute of Cancer Research London

Co-authored papers 1

Oliver B??gler

American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University

Co-authored papers 1

Henrik Gr??nberg

Karolinska Institute

Co-authored papers 1

Peter Nilsson

Linkoping University

Co-authored papers 1

Martin Hrab?? de Angelis

German Center for Diabetes Research (DZD e.V.)

Co-authored papers 1

Valerie Gailus-Durner

Institute of Experimental Genetics, German Mouse Clinic