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Author Details

Timothy A Lewis
National Institute of Allergy and Infectious Diseases, National Institutes of Health
1990
56
30
PMIDPaper TitleJournal TitlePublished Year
36068482The Opioid Epidemic: a Crisis Disproportionately Impacting Black Americans and Urban Communities.J Racial Ethn Health Disparities2023
36596894NIAID workshop on T cell technologies.Nat Immunol2023
35332332Systematic identification of biomarker-driven drug combinations to overcome resistance.Nat Chem Biol2022
34272366Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.Nat Commun2021
33246941Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.J Biol Chem2020
32005668Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.J Biol Chem2020
30789961Casting a wider net: Immunosurveillance by nonclassical MHC molecules.PLoS Pathog2019
31749907Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.ACS Med Chem Lett2019
30880155Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.Cell Chem Biol2019
29153505Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.Structure2017
27064299Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.ACS Chem Biol2016
26656089Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.Nat Chem Biol2016
27641501Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.Cell2016
27694802Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Nat Chem Biol2016
27602946Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.Nature2016
27994748Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.ACS Med Chem Lett2016
26314865Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.Elife2015
26478787Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport.ACS Med Chem Lett2015
24737027A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.Mol Cancer Ther2014
25454272Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).Bioorg Med Chem Lett2014
23562243Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.Bioorg Med Chem Lett2013
22297109Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Bioorg Med Chem Lett2012
23074541Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.ACS Med Chem Lett2012
22726680Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis.Chem Biol2012
22863010Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Cell2012
22503247Identification of a selective small molecule inhibitor of breast cancer stem cells.Bioorg Med Chem Lett2012
22434908Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Proc Natl Acad Sci U S A2012
20123131Hematopoietic cell types: prototype for a revised cell ontology.J Biomed Inform2011
21802010AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Chem Biol2011
21907926Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.Cancer Cell2011
21555567Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.Proc Natl Acad Sci U S A2011
21209116Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.J Virol2011
20028085Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Bioconjug Chem2010
21874153Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.ACS Med Chem Lett2010
20550176Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.ACS Chem Biol2010
20126263A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.PLoS Biol2010
19098899Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.Nat Biotechnol2009
18285338Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.J Biol Chem2008
17486044Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Nat Chem Biol2007
17348730Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.J Comb Chem2007
17467987Discovery of new C3aR ligands. Part 1: arginine derivatives.Bioorg Med Chem Lett2007
16982730Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.Cancer Res2006
156869175-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.Bioorg Med Chem Lett2005
15966769Animal models for radiation injury, protection and therapy.Radiat Res2005
15054606Novel dual acting molecules possessing 5-lipoxygenase enzyme inhibition and histamine H(1) receptor antagonist properties.Inflamm Res2004
15482930Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.Bioorg Med Chem Lett2004
150810225-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.Bioorg Med Chem Lett2004
12517956Lipid raft-independent B cell receptor-mediated antigen internalization and intracellular trafficking.J Immunol2003
12639818Gallium arsenide exposure impairs splenic B cell accessory function.Int Immunopharmacol2003
11359820Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes.J Immunol2001
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Collaborators

Broad Institute
Co-authored papers 22
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Co-authored papers 8
Broad Institute of MIT and Harvard
Co-authored papers 6
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Co-authored papers 4
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Co-authored papers 3
Dana-Farber Cancer Institute
Co-authored papers 3
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Broad Institute of Harvard and MIT
Co-authored papers 2
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Co-authored papers 2
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Center for the Science of Therapeutics, Broad Institute
Co-authored papers 2
National Institute of Allergy and Infectious Diseases/National Institutes of Health
Co-authored papers 2
J. Craig Venter Institute
Co-authored papers 1
Broad Institute of Harvard and MIT
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Harvard Medical School, Blavatnik Institute
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
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Universite de Toulouse, Inserm, Universite Toulouse III-Paul Sabatier
Co-authored papers 1
Seattle Children's Research Institute
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 1