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Author Details

Su M Metcalfe
University of Cambridge Clinical School, LIFNanoRx Ltd
1984
87
27
PMIDPaper TitleJournal TitlePublished Year
35047909Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic "LIF" Into the Brain: Preclinical Proof of Concept.Front Med Technol2021
32296777Mesenchymal stem cells and management of COVID-19 pneumonia.Med Drug Discov2020
32681950Delivering the power of nanomedicine to patients today.J Control Release2020
29448112LIF and multiple sclerosis: One protein with two healing properties.Mult Scler Relat Disord2018
27924726Neurodegenerative Disease: A Perspective on Cell-Based Therapy in the New Era of Cell-Free Nano-Therapy.Curr Pharm Des2017
25303042Stem cell therapy versus T lymphocytes: friend or foe?Stem Cells2015
29942371Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology to Harness the Tolerogenic and Reparative Properties of LIF.Nanobiomedicine (Rij)2015
25934281Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF).Biomaterials2015
24821983The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.Development2014
25085990Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease.Dis Model Mech2014
22172276Targeted nanotherapy for induction of therapeutic immune responses.Trends Mol Med2012
23227162Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice.PLoS One2012
20977190Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.Mol Pharm2011
21921909Multiple sclerosis: One protein, two healing properties.Nature2011
21368774LIF in the regulation of T-cell fate and as a potential therapeutic.Genes Immun2011
19901269The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.J Histochem Cytochem2010
20962578A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.Cell Cycle2010
19342884Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.Cell Cycle2009
18282245In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3.Transpl Int2008
17632414Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription.Transplantation2007
17161353Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.Int Immunopharmacol2006
15670816Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance.FEBS Lett2005
16147533Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance.Philos Trans R Soc Lond B Biol Sci2005
16147527Introduction: immunoregulation: harnessing T cell biology for therapeutic benefit.Philos Trans R Soc Lond B Biol Sci2005
15589457Transplantation tolerance: gene expression profiles comparing allotolerance vs. allorejection.Int Immunopharmacol2005
15785381Leukemia inhibitory factor is linked to regulatory transplantation tolerance.Transplantation2005
15185378New rapamycin derivatives by precursor-directed biosynthesis.Chembiochem2004
11821948The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.Oncogene2002
12355453Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist.Eur J Immunol2002
12121281The interleukin-1 receptor antagonist gene: a single-copy variant of the intron 2 variable number tandem repeat (VNTR) polymorphism.Eur J Immunogenet2002
11267421Genetic modulators of interleukin 1 activity influence the development of chronic rejection in human thoracic allografts.Transplant Proc2001
10798785STAT 6 up-regulation by FK506 in the presence of interleukin-4.Transplantation2000
10836388Comparison between tacrolimus and cyclosporine as immunosuppressive agents compatible with tolerance induction by CD4/CD8 blockade.Transplantation2000
11056691P53 autoantibodies in 1006 patients followed up for breast cancer.Breast Cancer Res2000
11156359An ex vivo model of tolerance vs. rejection: comparison of different signal transducers and activators of transcription, STAT1, STAT4, STAT5 and STAT6.Clin Chem Lab Med2000
11112057Allo-tolerance and allorejection responses ex vivo.Transpl Int2000
10597303A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.Oncogene1999
10342309Potential for improved therapeutic index of FK506 in liposomal formulation demonstrated in a mouse cardiac allograft model.Transplantation1999
10327055Wild-type p53 protein shows calcium-dependent binding to F-actin.Oncogene1999
10083346Thymic-independent peripheral tolerance.Transplant Proc1999
10500655Hepatotrophic effect of cyclosporine and FK 506 is not mimicked by rapamycin.Transplant Proc1999
10496344Proteolytic cleavage of p53 mutants in response to mismatched DNA.Br J Cancer1999
10578277Comparative efficacy of liposomal FK 506 with FK 506 (tacrolimus) with and without anti-CD4/CD8 monoclonal antibodies.Transplant Proc1999
10578271FK 506 versus cyclosporine in combination with anti-CD4/CD8 monoclonal antibodies.Transplant Proc1999
10480422Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus or micro-emulsified cyclosporine.Transplantation1999
9745493Tolerance induction with peripheral blood lymphocyte depletion using monoclonal antibodies: tip of the iceberg?Transplant Proc1998
9473033Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.J Bacteriol1998
9865315In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin.Transplant Proc1998
9865297Comparative efficacy of liposomal FK506 with FK506.Transplant Proc1998
9349496Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.Oncogene1997
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Collaborators

University of Cambridge
Co-authored papers 5
Crescendo Biologics Ltd
Co-authored papers 4
John Van Geest Center for Brain Repair, University of Cambridge
Co-authored papers 2
University of Wisconsin-Madison
Co-authored papers 2
KTH Royal Institute of Technology
Co-authored papers 1
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Co-authored papers 1
American Medical Informatics Association, Oregon Health and Science University, Oregon State University, University of Colorado Anschutz Medical Campus, University of North Carolina at Chapel Hill, University of Wisconsin-Madison
Co-authored papers 1
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