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Author Details

Chris R J Kennedy
University of Ottawa
1995
79
32
PMIDPaper TitleJournal TitlePublished Year
36730247High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury.PLoS One2023
37632371Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology.Toxicol Pathol2023
36902363The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension.Int J Mol Sci2023
35300856A letter to the editor about "dopamine 1 receptor activation protects mouse diabetic podocytes injury via regulating the PKA/NOX-5/p38 MAPK axis".Exp Cell Res2022
35275988Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways.Diabetes2022
35176122Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy.PLoS One2022
31527829Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice.Lab Invest2020
32661394Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.Nat Neurosci2020
31112562A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections.PLoS One2019
30070142Podocyte NADPH Oxidase 5 Promotes Renal Inflammation Regulated by the Toll-Like Receptor Pathway.Antioxid Redox Signal2019
31308217PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice.Clin Sci (Lond)2019
31222503Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.Diabetologia2019
29251736PGE<sub>2</sub> EP<sub>1</sub> receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct.Lab Invest2018
30061705GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.Sci Rep2018
29873512Proteostasis as a therapeutic target in glomerular injury associated with mutant α-actinin-4.Am J Physiol Renal Physiol2018
29667913Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis.Am J Physiol Renal Physiol2018
29435202Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36.J Extracell Vesicles2018
29739827Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.Clin Sci (Lond)2018
29454750A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.Am J Pathol2018
29085960Transforming growth factor-β1 and phosphatases modulate COX-2 protein expression and TAU phosphorylation in cultured immortalized podocytes.Inflamm Res2018
28004150Assessment of urinary microparticles in normotensive patients with type 1 diabetes.Diabetologia2017
28747378NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy.Diabetes2017
27245461Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury.Antioxid Redox Signal2016
27313531Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells.Front Pharmacol2016
25312438Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.Hypertension2015
26629355Changing and challenging times for Canadian kidney health and disease research.Can J Kidney Health Dis2015
26121313Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors.Lab Invest2015
25630236Nox and renal disease.Clin Sci (Lond)2015
25415612NADPH oxidase 5 and renal disease.Curr Opin Nephrol Hypertens2015
24262797Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression.J Am Soc Nephrol2014
25514595A novel mouse model of advanced diabetic kidney disease.PLoS One2014
24662305Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.Biochim Biophys Acta2014
24676640Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury.J Am Soc Nephrol2014
24727547Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.J Biol Chem2014
22920224Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.Clin Sci (Lond)2013
24113456PTGER1 deletion attenuates renal injury in diabetic mouse models.Am J Pathol2013
23760288Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus.Kidney Int2013
23409070Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions.PLoS One2013
23531619Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes.Am J Physiol Endocrinol Metab2013
23349499Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance, and altered cathelicidin antimicrobial Peptide.Diabetes2013
22629438Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes.PLoS One2012
23130145Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence.J Am Heart Assoc2012
22475818Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice.Kidney Int2012
21808733Podocyte Injury Associated with Mutant α-Actinin-4.J Signal Transduct2011
19585264Mice with podocyte-specific overexpression of wild type alpha-actinin-4 are healthy controls for K256E-alpha-actinin-4 mutant transgenic mice.Transgenic Res2010
20705715What type of VEGF do you need?J Am Soc Nephrol2010
20889563Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK.Am J Pathol2010
20630933Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.Am J Physiol Renal Physiol2010
20671216A maladaptive role for EP4 receptors in podocytes.J Am Soc Nephrol2010
20362052Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes.Cell Signal2010
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Collaborators

James W Scholey
University Health Network, University of Toronto
Co-authored papers 6
David Z I Cherney
University Health Network, University of Toronto
Co-authored papers 5
Judith A Miller
University of Toronto
Co-authored papers 5
Vesta Lai
Toronto General Hospital (Y.L.
Co-authored papers 5
Heather N Reich
University Health Network and University of Toronto
Co-authored papers 2
Raymond C Harris
Vanderbilt University Medical Center
Co-authored papers 2
William L Stanford
Ottawa Hospital Research Institute
Co-authored papers 1
Katey J Rayner
University of Ottawa
Co-authored papers 1
Sylvain Baillet
Montreal Neurological Institute, McGill University
Co-authored papers 1
Rahim Moineddin
University of Toronto
Co-authored papers 1
Stuart Yang
Toronto General Research Institute, University Health Network
Co-authored papers 1
Andrew M Herzenberg
University of Toronto
Co-authored papers 1
Paul C Boutros
University of California los angeles
Co-authored papers 1
Bernard Zinman
Mount Sinai Hospital, University of Toronto
Co-authored papers 1
Jian Ying Xuan
Zhuji Affiliated Hospital of Wenzhou Medical University
Co-authored papers 1
Stephenie D Prokopec
University Health Network
Co-authored papers 1
Mary-Ellen Harper
and Ottawa Institute of Systems Biology, University of Ottawa
Co-authored papers 1
Release 1.2