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Author Details

Jonathan F Fay
University of North Carolina School of Medicine
2002
22
15
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36302898Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.Nat Chem Biol2023
35977511Molecular insights into the regulation of constitutive activity by RNA editing of 5HT<sub>2C</sub> serotonin receptors.Cell Rep2022
35835867Inactive and active state structures template selective tools for the human 5-HT<sub>5A</sub> receptor.Nat Struct Mol Biol2022
35371504High-speed high-resolution data collection on a 200 keV cryo-TEM.IUCrJ2022
36450989Molecular basis for selective activation of DREADD-based chemogenetics.Nature2022
36087581Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.Neuron2022
36012518Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles.Int J Mol Sci2022
34789874Structure, function and pharmacology of human itch GPCRs.Nature2021
30281975Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.Biochemistry2018
30021106Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs.Biophys J2018
30109929R-Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator.Biochemistry2018
28750810Purification of Functional CB<sub>1</sub> and Analysis by Site-Directed Fluorescence Labeling Methods.Methods Enzymol2017
28092267Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.Elife2017
27702898Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.Proc Natl Acad Sci U S A2016
26100912Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.Proc Natl Acad Sci U S A2015
24724832Rhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin binding.Biochemistry2014
25086504Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes.Nat Methods2014
24206272The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.Biochemistry2013
22846992A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.J Biol Chem2012
15952782Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding.Biochemistry2005
12547830Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2.J Biol Chem2003
12464112Design, expression, and characterization of a synthetic human cannabinoid receptor and cannabinoid receptor/ G-protein fusion protein.J Pept Res2002
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Collaborators

Brian E Krumm
University of North Carolina School of Medicine
Co-authored papers 5
Ryan H Gumpper
UNC School of Medicine
Co-authored papers 5
Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 5
Kuglae Kim
University of North Carolina School of Medicine
Co-authored papers 3
Can Cao
University of North Carolina School of Medicine
Co-authored papers 3
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
Carl-Mikael Suomivuori
Stanford University School of Medicine
Co-authored papers 1
Lily Yeh Jan
Co-authored papers 1
Marc A D??mgen
Stanford University
Co-authored papers 1
Georgios Skiniotis
Stanford University School of Medicine
Co-authored papers 1
Jeffrey F DiBerto
University of North Carolina at Chapel Hill
Co-authored papers 1
Bryan L Roth
UNC School of Medicine
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Ron O Dror
Co-authored papers 1
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Petr Popov
Skolkovo Institute of Science and Technology
Co-authored papers 1
Xi-Ping Huang
University of North Carolina School of Medicine
Co-authored papers 1
Shicheng Zhang
University of North Carolina at Chapel Hill
Co-authored papers 1
Michael J Robertson
Stanford University School of Medicine
Co-authored papers 1
Alpay B Seven
Stanford University School of Medicine
Co-authored papers 1
Ouliana Panova
Stanford University School of Medicine, Stanford University
Co-authored papers 1
Joel Karpiak
Department of Pharmaceutical Sciences, University of California San Francisco
Co-authored papers 1
Xiaofang Zhong
School of Pharmacy, University of Wisconsin-Madison
Co-authored papers 1
David E Nichols
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers 1
Qing Xie
Co-authored papers 1
Ximena Barros-??lvarez
Stanford University School of Medicine
Co-authored papers 1
Release 1.2