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Author Details

Simon J Boulton
The Francis Crick Institute
1996
150
65
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36701230Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways.Cell Rep2023
37802026Negative DNA supercoiling induces genome-wide Cas9 off-target activity.Mol Cell2023
37499663Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein.Mol Cell2023
37080969Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.Nat Commun2023
37344587Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.Nature2023
37044098The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining.Mol Cell2023
36815444Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".J Med Chem2023
36689546Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.Clin Cancer Res2023
35081133Proline-specific aminopeptidase P prevents replication-associated genome instability.PLoS Genet2022
35649380Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis.Cell Rep2022
35439434H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ.Mol Cell2022
36455556POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.Mol Cell2022
36207294Search and processing of Holliday junctions within long DNA by junction-resolving enzymes.Nat Commun2022
34937945HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.Nature2022
33479235Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres.Nat Commun2021
33905417Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation.PLoS One2021
33833118Targeting the nucleotide salvage factor DNPH1 sensitizes <i>BRCA</i>-deficient cells to PARP inhibitors.Science2021
34545070Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function.Nat Commun2021
34486521Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.Elife2021
34563478Tackling PARP inhibitor resistance.Trends Cancer2021
34186335Mechanism of mitotic recombination: insights from C. elegans.Curr Opin Genet Dev2021
34214445RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection.Mol Cell2021
34169285Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis.STAR Protoc2021
34140467Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.Nat Commun2021
34136834A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue.STAR Protoc2021
33361389The end protection problem-an unexpected twist in the tail.Genes Dev2021
33333017Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.Mol Cell2021
33421363Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.Mol Cell2021
33239783TRF2-independent chromosome end protection during pluripotency.Nature2021
33041047Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.Trends Genet2021
32460026Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication.Cell Rep2020
32080884SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres.EMBO J2020
33357438RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions.Cell Rep2020
33357431Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.Cell Rep2020
32755577Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.Cell Rep2020
31050911Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.J Clin Oncol2019
31723267CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle.Nature2019
31302002IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.Mol Cell2019
31371435Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination.Genes Dev2019
31447390SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.Mol Cell2019
29290468Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.Cell2018
30217558POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.Mol Cell2018
30526646Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis.Genome Biol2018
30503519DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.Am J Hum Genet2018
29754823Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.Mol Cell2018
29376191New Editor-in-Chief-welcome to Simon Boulton!Chromosoma2018
29653955Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.Cancer Discov2018
29590065Beyond PARP-POLθ as an anticancer target.Science2018
29351848A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.Mol Cell2018
28655905Mechanisms of DNA-protein crosslink repair.Nat Rev Mol Cell Biol2017
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Technical University Dresden
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David A D Parry
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The Fifth Affiliated Hospital, Sun Yat-sen University
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Murielle P Serres
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Release 1.2