Author details

Full Name

William B Klimstra

Affiliation

ORCID

Career Start Year

1998

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37609165	Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner.	bioRxiv	2023
38014196	Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus.	bioRxiv	2023
37736038	Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants.		2023
37804831	Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.	Cell	2023
37613788	Scalable Analysis Pipeline for Mapping Brain Cells in Big Microscopy Data.	Microsc Microanal	2023
35191823	Glycosaminoglycan binding by arboviruses: a cautionary tale.	Journal of General Virology	2022
35696423	Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus.	PLoS Pathogens	2022
35867819	Cryo-EM structures of alphavirus conformational intermediates in low pH-triggered prefusion states.	Proc Natl Acad Sci U S A	2022
36680046	In Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates.		2022
34228597	Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants.	Human Vaccines and Immunotherapeutics	2022
35297953	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.	J Exp Med	2022
34416146	Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.	Cell	2021
33534855	Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques.	PLoS Pathogens	2021
34039613	Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses.	Sci Adv	2021
33655253	Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses.	bioRxiv	2021
34341790	Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines.		2021
34416147	Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress.	Cell	2021
32607507	SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients.		2020
32249203	Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.	EBioMedicine	2020
32245806	Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues.	Proc Natl Acad Sci U S A	2020
32047126	Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry.	mBio	2020
33208938	LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.	Nature	2020
32933112	Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKÎ² Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis.	Viruses	2020
32821033	SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients.	Journal of General Virology	2020
33301709	Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.	Cell	2020
32584818	Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis.	PLoS ONE	2020
32568661	Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions.	Emerg Infect Dis	2020
32511433	Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions.	medRxiv	2020
32946524	SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts.	PLoS Pathogens	2020
31480472	Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule.	Viruses	2019
31744158	Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses.	Pathogens	2019
31578290	Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection.	Journal of Virology	2019
31658290	Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus.	PLoS Pathogens	2019
30455470	Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.	Nat Microbiol	2019
30396029	Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats.	Virology	2019
30742691	Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants.	PLoS Pathogens	2019
31253680	A Vibrating Mesh Nebulizer as an Alternative to the Collison Three-Jet Nebulizer for Infectious Disease Aerobiology.	Applied and Environmental Microbiology	2019
29769725	Mxra8 is a receptor for multiple arthritogenic alphaviruses.	Nature	2018
30540945	Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.	Cell Rep	2018
30232164	The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.	mSphere	2018
29387474	Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.	npj Vaccines	2018
29691338	The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.	mBio	2018
27989642	MicroRNA Regulation of RNA Virus Replication and Pathogenesis.	Trends in Molecular Medicine	2017
28468884	Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus.	Journal of Virology	2017
28686653	Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.	PLoS One	2017
28487016	The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.	Placenta	2017
28398253	T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models.	Viruses	2017
29281739	Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.	PLoS Pathogens	2017
28288385	Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses.	Current Opinion in Virology	2017
27632170	Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.	PLoS Neglected Tropical Diseases	2016