Author details

Full Name

Mariella G Filbin

Affiliation

ORCID

Career Start Year

2013

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37702430	Diffuse midline glioma invasion and metastasis rely on cell-autonomous signaling.	Neuro Oncol	2024
38039965	A road map for the treatment of pediatric diffuse midline glioma.	Cancer Cell	2024
37524847	A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4.		2023
35640920	Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma.	Neuro-Oncology	2023
36197833	Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods.	Neuro-Oncology	2023
35605606	Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.	Neuro Oncol	2023
36445407	Erratum to: Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods.	Neuro-Oncology	2023
37584601	Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.	Cancer Discov	2023
37802053	TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory.	Cancer Cell	2023
36711554	Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression.	bioRxiv	2023
36759899	Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.	Acta Neuropathol Commun	2023
36944298	Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.	Neoplasia	2023
35130560	GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.	Nature	2022
36305736	BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.	Cancer Discov	2022
36040810	VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.	JCI Insight	2022
35745584	Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors.	Pharmaceuticals (Basel)	2022
35990702	An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin.	Neurooncol Adv	2022
36185807	Immunotherapy approaches for the treatment of diffuse midline gliomas.	OncoImmunology	2022
35716669	Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas.	Molecular Cell	2022
36471067	The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.	Nat Genet	2022
35157764	Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.	Neuro Oncol	2022
34613815	Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.	Sci Transl Med	2021
34046693	Targeting fibroblast growth factor receptors to combat aggressive ependymoma.	Acta Neuropathol	2021
33565268	Outcomes after first relapse of childhood intracranial ependymoma.	Pediatric Blood and Cancer	2021
33930294	The imitation game: How glioblastoma outmaneuvers immune attack.	Cell	2021
33090244	Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas.	Acta Neurochir (Wien)	2021
33333210	Understanding the epigenetic landscape and cellular architecture of childhood brain tumors.	Neurochemistry International	2021
32663469	Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.	Cancer Cell	2020
31895160	The growing role of epigenetics in childhood cancers.	Current Opinion in Pediatrics	2020
33259802	Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.	Cell	2020
32693052	Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.	Developmental Cell	2020
32780261	Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.	Journal of Neuro-Oncology	2020
32665022	Molecular and clinicopathologic features of gliomas harboring NTRK fusions.	Acta Neuropathol Commun	2020
31341285	Resolving medulloblastoma cellular architecture by single-cell genomics.	Nature	2019
31588023	Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.	Mol Cell	2019
31631026	Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.	Cancer Cell	2019
31571114	Increasing value of autopsies in patients with brain tumors in the molecular era.	J Neurooncol	2019
31768071	Stalled developmental programs at the root of pediatric brain tumors.	Nat Genet	2019
31539496	Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.	Cell	2019
31427603	Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.	Nat Commun	2019
30842674	Developmental origins and emerging therapeutic opportunities for childhood cancer.	Nature Medicine	2019
29548059	Gliomas in Children.	Semin Neurol	2018
28830841	Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas.	Pharmacol Ther	2018
29954445	Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.	Acta Neuropathol Commun	2018
29674595	Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.	Science	2018
28104717	Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.	Neuro Oncol	2017
28360267	Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.	Science	2017
27806376	Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.	Nature	2016
26980161	Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time.	Annu Rev Pathol	2016
26575352	A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.	Journal of Visualized Experiments	2015