Author details

Full Name

Bruce R Conklin

Affiliation

Gladstone Institutes

ORCID

Career Start Year

1984

Papers

149

H Index

Expertise

CM4AI Collaborator

Trey Ideker (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36413603	Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.	J Gene Med	2023
35027731	BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.	Nat Cell Biol	2022
36459969	A reference human induced pluripotent stem cell line for large-scale collaborative studies.	Cell Stem Cell	2022
35938400	Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.	Circulation	2022
35182466	Transcription factor protein interactomes reveal genetic determinants in heart disease.	Cell	2022
34087997	Transcription factor overexpression drives reliable differentiation of retinal pigment epithelium from human induced pluripotent stem cells.	Stem Cell Res	2021
33501440	BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.	bioRxiv	2021
33723017	SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.	Sci Transl Med	2021
34732726	Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies.	Nat Commun	2021
34403849	Bioengineered optogenetic model of human neuromuscular junction.	Biomaterials	2021
34485306	Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E.	Front Cell Dev Biol	2021
32492424	Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.	Cell Rep	2020
32090507	Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity.	Adv Healthc Mater	2020
32913194	Rapid, precise quantification of large DNA excisions and inversions by ddPCR.	Sci Rep	2020
32935097	SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.	bioRxiv	2020
32313254	CRISPR off-target detection with DISCOVER-seq.	Nat Protoc	2020
30389344	MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.	Dev Biol	2019
31759947	Automated Design of Pluripotent Stem Cell Self-Organization.	Cell Syst	2019
31416467	AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design.	Genome Biol	2019
31378668	Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.	Stem Cell Reports	2019
31367015	Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.	Nat Genet	2019
30710124	On the road to a gene drive in mammals.	Nature	2019
31000663	Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.	Science	2019
29543795	Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.	Nat Protoc	2018
31015724	Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.	Nat Biomed Eng	2018
30298816	Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.	Elife	2018
29663322	Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.	Biotechnol Bioeng	2018
29717453	Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR.	Methods Mol Biol	2018
27869805	Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.	Nat Med	2017
28400398	Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.	Circ Res	2017
28724793	A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.	JCI Insight	2017
27980086	CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.	Science	2017
26724721	Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.	Curr Protoc Hum Genet	2016
27794120	BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.	Proc Natl Acad Sci U S A	2016
27363581	Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.	Nat Commun	2016
27250210	Using Digital Polymerase Chain Reaction to Detect Single-Nucleotide Substitutions Induced by Genome Editing.	Cold Spring Harb Protoc	2016
27250209	Detecting Single-Nucleotide Substitutions Induced by Genome Editing.	Cold Spring Harb Protoc	2016
27095412	Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.	Sci Rep	2016
27030102	Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.	Sci Rep	2016
26971820	CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.	Cell Stem Cell	2016
26812940	Generating trunk neural crest from human pluripotent stem cells.	Sci Rep	2016
25333967	Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.	Tissue Eng Part C Methods	2015
26172574	Self-organizing human cardiac microchambers mediated by geometric confinement.	Nat Commun	2015
25917236	Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.	J Bone Miner Res	2015
25825768	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	Proc Natl Acad Sci U S A	2015
25975378	Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.	Acta Neuropathol	2015
25704759	Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.	Exp Cell Res	2015
25622143	Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.	Nat Neurosci	2015
25695968	GÎ±i/o-coupled receptor signaling restricts pancreatic Î²-cell expansion.	Proc Natl Acad Sci U S A	2015
25748532	Human iPSC-based cardiac microphysiological system for drug screening applications.	Sci Rep	2015

1 - 50 of 149

Nicola de Prisco

Columbia University Irving Medical Center

Career Start Year 2016

Number of shared co-authors 1

Jens Hansen

Icahn School of Medicine at Mount Sinai

Career Start Year 2011

Number of shared co-authors 0

James L Engel

David Geffen School of Medicine, University of California los angeles

Career Start Year 2009

Number of shared co-authors 2

Mohit Jain

Cumming School of Medicine, University of Calgary, 0 Hospital Drive NW

Career Start Year 2000

Number of shared co-authors 0

Bingbing Yuan

Whitehead Institute for Biomedical Research

Career Start Year 2000

Number of shared co-authors 1

Peter White

The Ohio State University

Career Start Year 2000

Number of shared co-authors 0

David K Crossman

University of Alabama at Birmingham

Career Start Year 2000

Number of shared co-authors 0

Thomas P Zwaka

Icahn School of Medicine at Mount Sinai

Career Start Year 2000

Number of shared co-authors 3

Stephane Angers

Department of Pharmaceutical Sciences, University of Toronto

Career Start Year 1999

Number of shared co-authors 2

Yuji Nakada

University of Alabama at Birmingham

Career Start Year 1998

Number of shared co-authors 0

Grace Lee

Bowdoin College

Career Start Year 1997

Number of shared co-authors 0

Reka Toth

German Cancer Research Center (DKFZ)

Career Start Year 1997

Number of shared co-authors 0

Anthony P Orth

Genomics Institute of the Novartis Research Foundation

Career Start Year 1995

Number of shared co-authors 3

Herbert Schulz

Clinic for Plastic, Otto von Guericke University

Career Start Year 1995

Number of shared co-authors 2

Thomas Lemberger

German Cancer Research Center

Career Start Year 1994

Number of shared co-authors 1

Michael And??ng

Karolinska Institutet

Career Start Year 1994

Number of shared co-authors 0

Dmitry A Ovchinnikov

The Florey Institute for Neuroscience and Mental Health, University of Melbourne

Career Start Year 1994

Number of shared co-authors 0

Martin Hrab?? de Angelis

German Center for Diabetes Research (DZD e.V.)

Career Start Year 1993

Number of shared co-authors 5

Ping Wei

Fudan University Shanghai Cancer Center

Career Start Year 1993

Number of shared co-authors 2

Christopher P Austin

St. George's University Medical School

Career Start Year 1990

Number of shared co-authors 3

Juan Carlos Izpisua Belmonte

Inc., Salk Institute for Biological Studies

Career Start Year 1989

Number of shared co-authors 4

William T Pu

Boston Children's Hospital, Harvard Medical School

Career Start Year 1989

Number of shared co-authors 7

Stuart C Sealfon

Icahn School of Medicine at Mount Sinai

Career Start Year 1988

Number of shared co-authors 1

Ernst J Wolvetang

Australian Institute for Bioengineering and Nanotechnology, University of Queensland

Career Start Year 1987

Number of shared co-authors 1

Gregory A Michelotti

Inc. Research Triangle Park

Career Start Year 1987

Number of shared co-authors 0

Rob Hooft van Huijsduijnen

Vrije Universiteit Amsterdam (VU)

Career Start Year 1987

Number of shared co-authors 2

Daniel J Garry

University of Minnesota

Career Start Year 1986

Number of shared co-authors 0

Michel Bouvier

Institute for Research in Immunology and Cancer, Universite de Montreal

Career Start Year 1981

Number of shared co-authors 1

Ravi Iyengar

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

Career Start Year 1976

Number of shared co-authors 2

Bruce J Aronow

Cincinnati Children's Hospital Medical Center

Career Start Year 1975

Number of shared co-authors 3

row(s) 1 - 30 of 30

Mohammad A Mandegar

Gladstone Institute of Cardiovascular Disease

Co-authored papers 13

Henry R Bourne

Co-authored papers 13

Alexander R Pico

Institute of Data Science and Biotechnology, Gladstone Institutes

Co-authored papers 12

Deepak Srivastava

Gladstone Institutes San Francisco

Co-authored papers 11

Luke M Judge

Gladstone Institutes

Co-authored papers 10

Kristina Hanspers

Gladstone Institutes

Co-authored papers 10

Yuichiro Miyaoka

Tokyo Metropolitan Institute of Medical Science, Japan Gladstone Institutes

Co-authored papers 10

Po-Lin So

Gladstone Institutes

Co-authored papers 9

Nathaniel Huebsch

Washington University in St. Louis

Co-authored papers 9

Amanda H Chan

Gladstone Institutes

Co-authored papers 7

Chris T Evelo

Maastricht University

Co-authored papers 7

Todd C McDevitt

Gladstone Institute of Cardiovascular Disease

Co-authored papers 6

Thomas Kelder

Maastricht University

Co-authored papers 6

Jonathan S Weissman

Whitehead Institute for Biomedical Research

Co-authored papers 5

Jennie Yoo

University of California San Francisco Department of Psychiatry

Co-authored papers 4

Katherine S Pollard

Gladstone Institutes

Co-authored papers 4

Juan A Perez-Bermejo

Gladstone Institutes

Co-authored papers 4

Annie Truong

Gladstone Institutes

Co-authored papers 4

Yu Huang

Gladstone Institutes San Francisco

Co-authored papers 4

Nevan J Krogan (CM4AI)

University of California San Francisco

Co-authored papers 4

William C Skarnes

Wellcome Trust Sanger Institute

Co-authored papers 4

Christopher Ian Spencer

Gladstone Institute of Cardiovascular Disease

Co-authored papers 4

Luke A Gilbert

Arc Institute

Co-authored papers 3

Martin Kampmann

Institute for Neurodegenerative Diseases, University of California san francisco

Co-authored papers 3

Paul C Simpson

Co-authored papers 3

Mark Mercola

Co-authored papers 3

Alex S Nord

UC Davis Center for Neuroscience.

Co-authored papers 3

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Co-authored papers 3

Bernard Lo

Canada Institute for Health Policy, University of Toronto, 155 College Street

Co-authored papers 3

Jacob E Corn

Co-authored papers 2

1 - 30

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