Author details

Full Name

Brian D Hobbs

Affiliation

ORCID

Career Start Year

2014

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36702996	Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.	Nat Genet	2023
37788444	Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function.	Am J Respir Crit Care Med	2023
37749248	Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.	Nat Genet	2023
37662265	WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.	medRxiv	2023
37624745	Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline-A Multinational Registry Analysis.		2023
37595761	Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.	J Allergy Clin Immunol	2023
37523715	A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.	Am J Respir Crit Care Med	2023
37286633	Large scale proteomic studies create novel privacy considerations.	Sci Rep	2023
37083575	Deep learning on graphs for multi-omics classification of COPD.		2023
37069358	Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.	Nat Genet	2023
37041558	Identifying chronic obstructive pulmonary disease from integrative omics and clustering in lung tissue.	BMC Pulm Med	2023
36952240	Variability in <i>MUC5B</i> Expression Is Dependent on Genotype and Endotype in Idiopathic Pulmonary Fibrosis.	Am J Respir Crit Care Med	2023
36945553	Clinical Features of Genetic Resilience in Chronic Obstructive Pulmonary Disease.	medRxiv	2023
36865145	Identifying COPD subtypes using multi-trait genetics.	medRxiv	2023
36726148	X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.	Respir Res	2023
36155958	Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease.	EBioMedicine	2022
35715807	Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies.	Respir Res	2022
35504013	Genetic Association Study Advances Idiopathic Pulmonary Fibrosis Pathophysiology and Health Equity.	American Journal of Respiratory and Critical Care Medicine	2022
35447890	Blood miRNAs Are Linked to Frequent Asthma Exacerbations in Childhood Asthma and Adult COPD.	Noncoding RNA	2022
35438610	The Proteomic Profile of Interstitial Lung Abnormalities.	Am J Respir Crit Care Med	2022
35427534	Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder.	Lancet Respir Med	2022
35115341	A polygenic risk score and age of diagnosis of COPD.	Eur Respir J	2022
35025710	Recent advancements in understanding the genetic involvement of alpha-1 antitrypsin deficiency associated lung disease: a look at future precision medicine approaches.		2022
34929108	Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities.	Am J Respir Crit Care Med	2022
34767496	Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts.	Am J Respir Crit Care Med	2022
34762809	Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.	Am J Respir Crit Care Med	2022
34739356	Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease.	Am J Respir Crit Care Med	2022
34553764	Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.	Hum Mol Genet	2022
36383614	A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.	PLoS Genet	2022
33872788	Commercially Available Blocking Oligonucleotides Effectively Suppress Unwanted Hemolysis-Related miRNAs in a Large Whole-Blood RNA Cohort.	J Mol Diagn	2021
33106845	Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.	Am J Epidemiol	2021
34913977	Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function.	JAMA Netw Open	2021
34784346	Alternative poly-adenylation modulates Î±1-antitrypsin expression in chronic obstructive pulmonary disease.	PLoS Genet	2021
34777474	Identifying miRNA-mRNA Networks Associated With COPD Phenotypes.	Frontiers in Genetics	2021
34582791	Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.	Am J Hum Genet	2021
34523824	Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.	J Cachexia Sarcopenia Muscle	2021
34404834	A genome-wide association study of quantitative computed tomographic emphysema in Korean populations.	Sci Rep	2021
34261472	Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors.	BMC Pulm Med	2021
34216018	Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury.	Hepatology	2021
34087167	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
33982900	Relationship Between Rheumatoid Arthritis and Pulmonary Function Measures on Spirometry in the UK Biobank.	Arthritis Rheumatol	2021
33909500	A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease.	Am J Physiol Lung Cell Mol Physiol	2021
33887194	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
31283919	Subtyping COPD by Using Visual and Quantitative CT Imaging Features.	Chest	2020
33239407	Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies.	BMJ Open Respir Res	2020
33181463	Corrigendum to 'A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19'.	EBioMedicine	2020
33039714	A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19.	EBioMedicine	2020
32654700	Comorbidity-Based Clusters Contain Chaos in COPD.	Chest	2020
32621460	Why is Disease Penetration So Variable? Role of Genetic Modifiers of Lung Function in Alpha-1 Antitrypsin Deficiency.	Chronic Obstr Pulm Dis	2020
32477647	Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions.	AMIA Jt Summits Transl Sci Proc	2020