Skip to Main Content

Author Details

Frederick S Buckner
University of Washington
1986
136
41
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
33970891Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis.Am J Trop Med Hyg2021
33493793The Tryp and the Pendulum.EBioMedicine2021
33871981Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.ACS Infect Dis2021
33753338Spontaneous Selection of <i>Cryptosporidium</i> Drug Resistance in a Calf Model of Infection.Antimicrob Agents Chemother2021
32268005Hydroxychloroquine for Treatment of SARS-CoV-2 Infection? Improving Our Confidence in a Model-Based Approach to Dose Selection.Clin Transl Sci2020
32033395Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach.Trop Med Infect Dis2020
31808676Setting Our Sights on Infectious Diseases.ACS Infect Dis2020
31888785A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia.Allergy Asthma Proc2020
32011682Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.J Antimicrob Chemother2020
31706668A new chemotype with promise against Trypanosoma cruzi.Bioorg Med Chem Lett2020
33479683Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against <i>Trypanosoma brucei</i>.RSC Med Chem2020
30745384Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.Antimicrob Agents Chemother2019
31192168Bioactivity of Farnesyltransferase Inhibitors Against <i>Entamoeba histolytica</i> and <i>Schistosoma mansoni</i>.Front Cell Infect Microbiol2019
29633973The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.Acta Crystallogr F Struct Biol Commun2018
30655955Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.ACS Med Chem Lett2018
27992217Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.J Med Chem2017
28465105Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.Bioorg Med Chem Lett2017
28110521From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.ACS Infect Dis2017
28427904Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Biochimie2017
28187957Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.Bioorg Med Chem2017
288358071-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-<i>Trypanosoma brucei</i> Agents: SAR and in Vivo Efficacy.ACS Med Chem Lett2017
28848016Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.Antimicrob Agents Chemother2017
28740614New Class of Antitrypanosomal Agents Based on Imidazopyridines.ACS Med Chem Lett2017
27500735Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.PLoS One2016
27788467Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.Eur J Med Chem2016
27658298Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.PLoS One2016
276276285-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.ACS Infect Dis2016
27501246Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.Nature2016
25163684Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.J Biomol Screen2015
26249349A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Acta Crystallogr D Biol Crystallogr2015
26324270Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.Antimicrob Agents Chemother2015
24354316Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.J Med Chem2014
25365529Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.Chem Rev2014
25033456Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.PLoS Negl Trop Dis2014
24743796Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.PLoS Negl Trop Dis2014
23587950Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.Antimicrob Agents Chemother2013
24120539Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.Bioorg Med Chem Lett2013
23665145Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design.Mol Biochem Parasitol2013
22877245Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.J Med Chem2012
24533285Recent highlights in anti-protozoan drug development and resistance research.Int J Parasitol Drugs Drug Resist2012
23277882Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.Int J Parasitol Drugs Drug Resist2012
22948920Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.Acta Crystallogr D Biol Crystallogr2012
22720744Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.J Med Chem2012
22777048Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.Antimicrob Agents Chemother2012
22902861Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.Structure2012
21282428Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.Antimicrob Agents Chemother2011
22073170An essential farnesylated kinesin in Trypanosoma brucei.PLoS One2011
21820553Experimental chemotherapy and approaches to drug discovery for Trypanosoma cruzi infection.Adv Parasitol2011
21517059Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.J Med Chem2011
21750879Screening a fragment cocktail library using ultrafiltration.Anal Bioanal Chem2011
  • 1 - 50 of 136

Recommended Authors

Madeline R Luth
University of California San Diego
Career Start Year 2017
Number of shared co-authors 1
Gisele Bulh??es Portapilla
School of Pharmaceutical Sciences of Ribeirao Preto - University of Sao Paulo
Career Start Year 2016
Number of shared co-authors 0
Vida Ahyong
University of California berkeley
Career Start Year 2013
Number of shared co-authors 4
Melissa S Love
a Division of The Scripps Research Institute
Career Start Year 2012
Number of shared co-authors 3
David J Meyers
Johns Hopkins School of Medicine
Career Start Year 2008
Number of shared co-authors 0
Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 2005
Number of shared co-authors 0
Lluis Ballell
Global Health Pharma Unit
Career Start Year 2005
Number of shared co-authors 4
Case W McNamara
a division of The Scripps Research Institute La Jolla
Career Start Year 2004
Number of shared co-authors 5
Shirin Arastu-Kapur
Stanford University School of Medicine
Career Start Year 2003
Number of shared co-authors 1
Pooja Agarwal
SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, University of Cape Town
Career Start Year 2003
Number of shared co-authors 0
Noel Southall
National Center for Advancing Translational Sciences, National Institutes of Health
Career Start Year 2002
Number of shared co-authors 1
Alice Dawson
University of Dundee
Career Start Year 2002
Number of shared co-authors 0
Craig J Thomas
Center for Cancer Research, National Cancer Institute
Career Start Year 2001
Number of shared co-authors 1
Amanda K Lukens
Harvard T.H. Chan School of Public Health
Career Start Year 2000
Number of shared co-authors 0
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 1997
Number of shared co-authors 1
Kelli Kuhen
Genomics Institute of the Novartis Research Foundation
Career Start Year 1992
Number of shared co-authors 2
Elizabeth A Winzeler
University of California San Diego
Career Start Year 1991
Number of shared co-authors 9
Sabine Ottilie
University of California San Diego
Career Start Year 1991
Number of shared co-authors 0
Sally Freeman
Division of Pharmacy and Optometry, University of Manchester
Career Start Year 1988
Number of shared co-authors 0
Tur??n P Urm??nyi
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro
Career Start Year 1988
Number of shared co-authors 1
Alasdair Ivens
University of Washington School of Medicine
Career Start Year 1987
Number of shared co-authors 11
S??rgio de Albuquerque
School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo
Career Start Year 1986
Number of shared co-authors 0
Stuart L Schreiber
Broad Institute
Career Start Year 1985
Number of shared co-authors 1
Hans-Michael M??ller
Heidelberg University Biochemistry Center
Career Start Year 1982
Number of shared co-authors 1
Philip J Rosenthal
University of California at San Francisco
Career Start Year 1979
Number of shared co-authors 7
Dyann F Wirth
The Broad Institute
Career Start Year 1977
Number of shared co-authors 1
Alan H Fairlamb
University of Dundee
Career Start Year 1974
Number of shared co-authors 12
Jon Clardy
Harvard Medical School, Blavatnik Institute
Career Start Year 1973
Number of shared co-authors 1
Akhil B Vaidya
Center for Molecular Parasitology, Drexel University College of Medicine
Career Start Year 1971
Number of shared co-authors 5
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Career Start Year 1970
Number of shared co-authors 3

Collaborators

Wesley C Van Voorhis
Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 70
Christophe L M J Verlinde
University of Washington
Co-authored papers 53
Sayaka Shibata
Co-authored papers 14
Peter J Myler
University of Guelph
Co-authored papers 7
Ximena Barros-??lvarez
Stanford University School of Medicine
Co-authored papers 7
Elizabeth A Worthey
Heersink School of Medicine, The University of Alabama at Birmingham
Co-authored papers 6
Thomas Earnest
Washington University School of Medicine in St. Louis
Co-authored papers 5
Aaron Riechers
Co-authored papers 3
Donald D Lorimer
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Co-authored papers 2
Gregory J Crowther
Everett Community College
Co-authored papers 2
Keith O Hodgson
Stanford University
Co-authored papers 2
Kenneth Stuart
Seattle Children's Research Institute
Co-authored papers 2
John P Overington
Institute of Cardiovascular Science, University College London
Co-authored papers 2
Brian E Krumm
University of North Carolina School of Medicine
Co-authored papers 1
Maria A Doyle
Peter MacCallum Cancer Centre
Co-authored papers 1
Andrew L Hopkins
University of Dundee
Co-authored papers 1
David Baker
University of Washington
Co-authored papers 1
Matthew Berriman
Wellcome Sanger Institute
Co-authored papers 1
Gregg McAllister
Co-authored papers 1
Santiago J Carmona
AGORA Cancer Research Center
Co-authored papers 1
Ian M Carruthers
College of Life Sciences, University of Dundee
Co-authored papers 1
Douglas J LaCount
Purdue University
Co-authored papers 1
Feng Chen
Bayer Healthcare Pharmaceuticals
Co-authored papers 1
Stuart A Ralph
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
David S Roos
University of Pennsylvania
Co-authored papers 1
David P Kateete
College of Health Sciences, Makerere University
Co-authored papers 1
Solomon Nwaka
Institut fur Biochemie und Molekularbiologie, Universitat Freiburg
Co-authored papers 1
Hediye Erdjument-Bromage
Neuroscience Institute, NYU Grossman School of Medicine
Co-authored papers 1
Stanley Fields
University of Washington
Co-authored papers 1
Matthew C Altman
University of Washington School of Medicine, Seattle Benaroya Research Institute
Co-authored papers 1
Release 1.2