Author details

Full Name

Charles D Stiles

Affiliation

ORCID

Career Start Year

1972

Papers

172

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36305736	BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.	Cancer Discov	2022
31427603	Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.	Nat Commun	2019
28177281	Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.	Elife	2017
28472644	Population Control: Cortical Interneurons Modulate Oligodendrogenesis.	Neuron	2017
28355568	A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.	Cell Rep	2017
27402815	Tyrosine receptor kinase B is a drug target in astrocytomas.	Neuro Oncol	2017
28002790	Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.	Oncotarget	2017
28082416	A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.	Neuro Oncol	2017
28104717	Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.	Neuro Oncol	2017
27643505	Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.	ACS Chemical Biology	2016
27300432	Gliomas "Dope Up" for Growth.	Cancer Cell	2016
26829751	MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.	Nat Genet	2016
26575352	A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.	Journal of Visualized Experiments	2015
25825052	Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.	Neuro Oncol	2015
26461085	Of Brains and Blood: Developmental Origins of Glioma Diversity?	Cancer Cell	2015
24948806	An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells.	J Neurosci	2014
24507192	Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.	Neuron	2014
24589977	Pediatric low-grade gliomas: how modern biology reshapes the clinical field.	Biochim Biophys Acta	2014
23633565	Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.	Proc Natl Acad Sci U S A	2013
24270268	New progenitors NESTIN(g) in the EGL.	Nature Neuroscience	2013
24091529	Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.	Sci Rep	2013
23165259	Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.	Nat Rev Neurosci	2012
22510988	Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.	Development	2012
22821383	Prospective, high-throughput molecular profiling of human gliomas.	J Neurooncol	2012
22998861	Asleep at the switch: MEK kinases control transit to gliogenesis in developing cortex.	Neuron	2012
21884820	Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.	J Mol Diagn	2011
21397859	The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.	Cancer Cell	2011
21382551	Phosphorylation state of Olig2 regulates proliferation of neural progenitors.	Neuron	2011
21246394	Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.	J Neurooncol	2011
21727208	Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop.	Neuro Oncol	2011
20154675	Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.	Nature Genetics	2010
18682579	Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.	Neuro Oncol	2009
19741146	A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.	J Neurosci	2009
19293394	Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).	Neuro Oncol	2009
19924296	Profiling critical cancer gene mutations in clinical tumor samples.	PLoS One	2009
18579075	Glioma stem cells: a midterm exam.	Neuron	2008
17336898	Smadeningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma.	Developmental Cell	2007
17296553	Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.	Neuron	2007
17964020	Molecular pathogenesis of adult brain tumors and the role of stem cells.	Neurologic Clinics	2007
16469306	Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.	Dev Biol	2006
16464405	Targeted molecular therapy of malignant gliomas.	Current Oncology Reports	2006
16914578	Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.	Clin Cancer Res	2006
16682644	Development of NG2 neural progenitor cells requires Olig gene function.	Proc Natl Acad Sci U S A	2006
16846849	The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells.	Neuron	2006
16266984	Novel pheochromocytoma susceptibility loci identified by integrative genomics.	Cancer Research	2005
16103922	A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.	PLoS Genet	2005
16033648	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	BMC Dev Biol	2005
15389679	Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures.		2005
15865884	Targeted molecular therapy of malignant gliomas.	Current Neurology and Neuroscience Reports	2005
15198128	The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.	J Neuropathol Exp Neurol	2004