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Author Details

Mathieu Lupien
Princess Margaret Cancer Research Centre
2003
127
56
PMIDPaper TitleJournal TitlePublished Year
37365652Human papillomavirus integration transforms chromatin to drive oncogenesis.Genome Biol2023
37694973Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer.Cancer Discov2023
37600767The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.Front Immunol2023
37020039Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer.Oncogene2023
34556523Mutations in Noncoding <i>Cis</i>-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer.Mol Cancer Res2022
35578032PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.Nat Chem Biol2022
35487182Cancer-associated chromatin variants uncover the oncogenic role of transposable elements.Curr Opin Genet Dev2022
36041880Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer.Cold Spring Harb Perspect Med2022
36131042A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.Leukemia2022
35120647ecDNAs personify cancer gangsters.Mol Cell2022
32946061Pioneer of prostate cancer: past, present and the future of FOXA1.Protein Cell2021
33741908CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer.Nat Commun2021
33594052Biological and therapeutic implications of a unique subtype of NPM1 mutated AML.Nat Commun2021
33579912PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Nat Commun2021
35122077Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity.Nat Cancer2021
34644115Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer.Sci Adv2021
34642184Reorganization of the 3D Genome Pinpoints Noncoding Drivers of Primary Prostate Tumors.Cancer Res2021
34799402<i>Alu</i> insertion variants alter gene transcript levels.Genome Res2021
34343492TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate.Cell Stem Cell2021
33427645Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.Elife2021
33242413The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.Cell Stem Cell2021
33479238Large organized chromatin lysine domains help distinguish primitive from differentiated cell populations.Nat Commun2021
32297856Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Elife2020
31954095Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.Mol Cell2020
31974375Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.Nat Commun2020
32094913Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas.Nat Genet2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell2020
32416059Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.Cell Stem Cell2020
32546577Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Cancer Discov2020
30352278Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.Exp Hematol2019
31735626Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.Cancer Cell2019
31761532Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.Cell2019
31533978Identifying clusters of <i>cis</i>-regulatory elements underpinning TAD structures and lineage-specific regulatory networks.Genome Res2019
31526762Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.Cancer Cell2019
31249064High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.Genome Res2019
31591588Genome-wide germline correlates of the epigenetic landscape of prostate cancer.Nat Med2019
30926792Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.Nat Commun2019
30889379The Proteogenomic Landscape of Curable Prostate Cancer.Cancer Cell2019
31173706The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.Cell Stem Cell2019
30816925C3D: a tool to predict 3D genomic interactions between cis-regulatory elements.Bioinformatics2019
29317617Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro.Nat Commun2018
30033362Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19.Cell2018
29924804Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.PLoS Biol2018
29921600Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.J Cell Biol2018
30477433SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations.BMC Bioinformatics2018
29633761Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.Nat Commun2018
29633758Publisher Correction: ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters.Nat Commun2018
29769714Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Nature2018
29258295Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.Nature2018
29105538Organizing combinatorial transcription factor recruitment at cis-regulatory modules.Transcription2018
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Collaborators

Myles Brown
Co-authored papers 19
Alex Murison
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 19
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 18
Swneke D Bailey
Research Institute of the McGill University Health Centre
Co-authored papers 17
Paul Guilhamon
The Hospital for Sick Children
Co-authored papers 16
Benjamin Haibe-Kains
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 16
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 14
Ken J Kron
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 13
Paul C Boutros
University of California los angeles
Co-authored papers 12
Daniel D De Carvalho
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
Housheng Hansen He
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 11
Stanley Zhou
Princess Margaret Cancer Research Centre
Co-authored papers 11
Kinjal Desai
New York Presbyterian Morgan Stanley Children's Hospital
Co-authored papers 10
Gary D Bader
University of Toronto
Co-authored papers 10
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 10
Clifford A Meyer
Co-authored papers 9
Jason S Carroll
Co-authored papers 9
Trevor J Pugh
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Theodorus H van der Kwast
University Health Network, University of Toronto
Co-authored papers 9
Xiaole Shirley Liu
Co-authored papers 9
Michael Fraser
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Seyed Ali Madani Tonekaboni
Princess Margaret Cancer Research Centre
Co-authored papers 8
Musaddeque Ahmed
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
David W Cescon
Princess Margaret Cancer Centre
Co-authored papers 8
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 8
Robert G Bristow
University of Toronto
Co-authored papers 8
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Parisa Mazrooei
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Genevi??ve Deblois
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
Co-authored papers 7
Florence M G Cavalli
Institut Curie, PSL Research University
Co-authored papers 7
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