Author details

Full Name

Seth A Darst

Affiliation

The Rockefeller University

ORCID

Career Start Year

1988

Papers

164

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36795753	An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options.	Proc Natl Acad Sci U S A	2023
37870195	Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by <i>Achromobacter</i>.	J Nat Prod	2023
37116494	Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.	Mol Cell	2023
37338298	A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance.	mBio	2023
35260847	Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.	Nat Struct Mol Biol	2022
36471058	Polarity of the CRISPR roadblock to transcription.	Nat Struct Mol Biol	2022
33480355	Structural basis for transcription complex disruption by the Mfd translocase.	Elife	2021
33883267	Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.	Proc Natl Acad Sci U S A	2021
33758867	Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.	bioRxiv	2021
34851166	Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals.	mSphere	2021
35146496	Seeing gene expression in cells: the future of structural biology.	Fac Rev	2021
34696829	CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis.	Enzymes	2021
34599106	Structural origins of <i>Escherichia coli</i> RNA polymerase open promoter complex stability.	Proc Natl Acad Sci U S A	2021
34171296	Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.	Mol Cell	2021
33217329	Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.	Structure	2021
32160514	Stepwise Promoter Melting by Bacterial RNA Polymerase.	Mol Cell	2020
33199626	The antibiotic sorangicin A inhibits promoter DNA unwinding in a <i>Mycobacterium tuberculosis</i> rifampicin-resistant RNA polymerase.	Proc Natl Acad Sci U S A	2020
32676607	Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.	bioRxiv	2020
32783916	Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.	Cell	2020
32778833	Time-resolved cryo-EM using Spotiton.	Nat Methods	2020
30626643	Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.	Proc Natl Acad Sci U S A	2019
31841111	<i>E. coli</i> TraR allosterically regulates transcription initiation by altering RNA polymerase conformation.	Elife	2019
32285040	Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO.	J Struct Biol X	2019
31484766	Structural basis for transcription activation by Crl through tethering of Ï¿<sup>S</sup> and RNA polymerase.	Proc Natl Acad Sci U S A	2019
31310765	Mechanisms of Transcriptional Pausing in Bacteria.	J Mol Biol	2019
30626968	Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.	Nature	2019
29480804	Fidaxomicin jams <i>Mycobacterium tuberculosis</i> RNA polymerase motions needed for initiation via RbpA contacts.	Elife	2018
29887376	Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators.	Cell	2018
30297823	Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.	Nat Commun	2018
29499135	RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing.	Mol Cell	2018
28067618	Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.	Elife	2017
28223493	Crystal structure of <i>Aquifex aeolicus</i> Ï¿<sup>N</sup> bound to promoter DNA and the structure of Ï¿<sup>N</sup>-holoenzyme.	Proc Natl Acad Sci U S A	2017
28318486	Structural basis of transcription arrest by coliphage HK022 Nun in an <i>Escherichia coli</i> RNA polymerase elongation complex.	Elife	2017
28988932	6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.	Mol Cell	2017
28703128	Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.	Nat Commun	2017
28546214	RNA polymerase motions during promoter melting.	Science	2017
27920294	Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.	J Bacteriol	2017
27984731	Single-Molecule Real-Time 3D Imaging of the Transcription Cycle by Modulation Interferometry.	Cell	2016
25510492	Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.	Nucleic Acids Res	2015
26349032	Structure of a bacterial RNA polymerase holoenzyme open promoter complex.	Elife	2015
26349034	CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.	Elife	2015
26040003	Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.	Proc Natl Acad Sci U S A	2015
26195788	CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.	Proc Natl Acad Sci U S A	2015
25774659	TFIIB is only â¿¼9 Ã¿ away from the 5'-end of a trimeric RNA primer in a functional RNA polymerase II preinitiation complex.	PLoS One	2015
24699085	Promoter melting by an alternative Ï¿, one base at a time.	Nat Struct Mol Biol	2014
25002089	Bacterial sigma factors: a historical, structural, and genomic perspective.	Annu Rev Microbiol	2014
25108353	RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movement.	Nat Struct Mol Biol	2014
24778214	Structure of the branched intermediate in protein splicing.	Proc Natl Acad Sci U S A	2014
23374340	Structural basis of transcriptional pausing in bacteria.	Cell	2013
24116120	RNA-Seq reveals differential gene expression in Staphylococcus aureus with single-nucleotide resolution.	PLoS One	2013

1 - 50 of 164

Eunju Kwon

Yeungnam University

Career Start Year 2007

Number of shared co-authors 2

Arkadiusz W Kulczyk

Institute for Quantitative Biomedicine, Rutgers University

Career Start Year 2004

Number of shared co-authors 3

Peter L Freddolino

University of Michigan ann arbor

Career Start Year 2002

Number of shared co-authors 0

Brian P Hudson

The State University of New Jersey

Career Start Year 2000

Number of shared co-authors 4

Jan P Erzberger

UT Southwestern Medical Center

Career Start Year 1998

Number of shared co-authors 2

Mikel Valle

Center for Cooperative Research in Biosciences (CIC bioGUNE)

Career Start Year 1996

Number of shared co-authors 2

Craig D Kaplan

University of Pittsburgh

Career Start Year 1995

Number of shared co-authors 3

Min Zhou

College of Materials Science and Engineering, Hunan University

Career Start Year 1994

Number of shared co-authors 4

Nenad Ban

Institute of Molecular Biology and Biophysics, ETH Zurich

Career Start Year 1991

Number of shared co-authors 3

Mitchell D Miller

Rice University

Career Start Year 1989

Number of shared co-authors 0

Ralph E Davis

Stanford University School of Medicine

Career Start Year 1988

Number of shared co-authors 3

Scott A Lesley

Merck & Co., Inc.

Career Start Year 1987

Number of shared co-authors 3

Jennifer A Doudna

Innovative Genomics Institute, University of California berkeley

Career Start Year 1987

Number of shared co-authors 3

Donald D Lorimer

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Career Start Year 1986

Number of shared co-authors 1

John F Hunt

Columbia University

Career Start Year 1986

Number of shared co-authors 7

Mike O'Donnell

The Rockefeller University

Career Start Year 1985

Number of shared co-authors 5

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Career Start Year 1984

Number of shared co-authors 5

Mamoru Sato

Yokohama City University

Career Start Year 1982

Number of shared co-authors 2

Stephen K Burley

The State University of New Jersey

Career Start Year 1982

Number of shared co-authors 20

Udo Heinemann

Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)

Career Start Year 1980

Number of shared co-authors 4

Andrzej Joachimiak

Center for Structural Biology of Infectious Diseases, University of Chicago

Career Start Year 1979

Number of shared co-authors 8

Michael Brenowitz

Albert Einstein College of Medicine

Career Start Year 1979

Number of shared co-authors 4

Shigeyuki Yokoyama

Shinshu University School of Medicine

Career Start Year 1979

Number of shared co-authors 9

Mark R Sanderson

King's College

Career Start Year 1978

Number of shared co-authors 4

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 2

John A Tainer

The University of Texas MD Anderson Cancer Center

Career Start Year 1975

Number of shared co-authors 5

Stephen C Harvey

University of Pennsylvania

Career Start Year 1972

Number of shared co-authors 3

Alain Laederach

University of North Carolina at Chapel Hill

Career Start Year 1972

Number of shared co-authors 0

Jack F Greenblatt

College Street, University of Toronto

Career Start Year 1969

Number of shared co-authors 2

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 3

row(s) 1 - 30 of 30

Robert Landick

University of Wisconsin-Madison

Co-authored papers 26

Brian T Chait

The Rockefeller University

Co-authored papers 14

Roger D Kornberg

Stanford University

Co-authored papers 12

Rachel A Mooney

University of Wisconsin-Madison

Co-authored papers 10

Paul Dominic B Olinares

The Rockefeller University

Co-authored papers 9

Aled M Edwards

University of Toronto

Co-authored papers 8

Sergei Borukhov

Rowan University School of Osteopathic Medicine

Co-authored papers 5

Carol A Gross

University of California san francisco

Co-authored papers 4

Tom W Muir

Princeton University

Co-authored papers 4

David Feny??

Institute for Systems Genetics, NYU Grossman School of Medicine

Co-authored papers 4

Michael S Glickman

Memorial Sloan Kettering Cancer Center

Co-authored papers 4

Arun Malhotra

University of Miami Miller School of Medicine

Co-authored papers 4

David E Shaw

Columbia University

Co-authored papers 3

Marianna Orlova

The Research Institute of the McGill University Health Centre

Co-authored papers 3

Willy Wriggers

Old Dominion University

Co-authored papers 2

Allison Fay

Memorial Sloan Kettering Cancer Center

Co-authored papers 2

Francisco J Asturias

University of Colorado Anschutz Medical Campus

Co-authored papers 2

D Koulich

State University of New York Health Science Center at Brooklyn 11203

Co-authored papers 2

Christine A Olson

University of California los angeles

Co-authored papers 2

David Cowburn

Albert Einstein College of Medicine

Co-authored papers 2

Jonathan L Tupy

Lawrence Berkeley National Laboratory

Co-authored papers 1

David Swigon

University of Pittsburgh

Co-authored papers 1

Ad Bax

National Institutes of Health

Co-authored papers 1

Richard L Sidman

Harvard Medical School

Co-authored papers 1

David A Bushnell

Stanford University

Co-authored papers 1

Edward F DeLong

University of Hawai'i at Manoa

Co-authored papers 1

Jeremy M Rock

The Rockefeller University

Co-authored papers 1

Pamela J Bjorkman

Co-authored papers 1

Heidi J Sofia

National Human Genome Research Institute

Co-authored papers 1

Bridget Carragher

Columbia University

Co-authored papers 1

1 - 30

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