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Author Details

Susan Lindquist
Whitehead Institute for Biomedical Research
1980
328
132
PMIDPaper TitleJournal TitlePublished Year
35294249HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.Sci Adv2022
35688132The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.Cell2022
35294249HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.Sci Adv2022
35688132The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.Cell2022
34127794Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.Leukemia2021
34127794Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.Leukemia2021
33658354<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia.Sci Transl Med2021
33658354<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia.Sci Transl Med2021
32783929Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.Cell Rep2020
32015439HSF1 phase transition mediates stress adaptation and cell fate decisions.Nat Cell Biol2020
32905780Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.Cell Rep2020
32783929Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.Cell Rep2020
32015439HSF1 phase transition mediates stress adaptation and cell fate decisions.Nat Cell Biol2020
32905780Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.Cell Rep2020
30679438Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.Nat Commun2019
30527540Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.Mol Cell2019
31133756Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
31164776Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
30679438Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.Nat Commun2019
31213460Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.Clin Cancer Res2019
31213460Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.Clin Cancer Res2019
31164776Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
31133756Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
30527540Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.Mol Cell2019
29227471Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.Nat Chem Biol2018
29227471Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.Nat Chem Biol2018
29526462Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.Cell2018
29553718Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.Biochemistry2018
29546391Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.FEMS Yeast Res2018
29553718Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.Biochemistry2018
29526462Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.Cell2018
29546391Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.FEMS Yeast Res2018
28028240Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.Proc Natl Acad Sci U S A2017
28911198Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.Hum Mol Genet2017
28628299Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.ACS Chem Neurosci2017
28330994Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register.Proc Natl Acad Sci U S A2017
28792214Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.Biochemistry2017
29056345A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.Cell2017
29229832FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proc Natl Acad Sci U S A2017
29135981Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast.PLoS Biol2017
28215707HSP90 Shapes the Consequences of Human Genetic Variation.Cell2017
28131822Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Cell Syst2017
28131823In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.Cell Syst2017
28028240Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.Proc Natl Acad Sci U S A2017
28131822Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Cell Syst2017
28131823In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.Cell Syst2017
28330994Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register.Proc Natl Acad Sci U S A2017
28215707HSP90 Shapes the Consequences of Human Genetic Variation.Cell2017
29229832FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proc Natl Acad Sci U S A2017
29056345A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.Cell2017
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Collaborators

Luke Whitesell
University of Toronto
Co-authored papers 34
Sandro Santagata
Co-authored papers 17
James Shorter
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 12
Alex K Lancaster
Ronin Institute
Co-authored papers 11
Christine Queitsch
University of Washington
Co-authored papers 9
Can Kayatekin
Co-authored papers 9
Pavan K Auluck
Co-authored papers 8
Gregory A Newby
Co-authored papers 8
Bonnie Berger
Massachusetts Institute of Technology
Co-authored papers 7
Aaron D Gitler
Stanford University School of Medicine
Co-authored papers 7
Todd A Sangster
University of Chicago
Co-authored papers 6
Marc Vidal
Blavatnik Institute, Harvard Medical School
Co-authored papers 6
Catherine A McLellan
Whitehead Institute
Co-authored papers 5
Saranna Fanning
Co-authored papers 5
Ernest Fraenkel
Co-authored papers 5
Yolanda Sanchez
Collegeville
Co-authored papers 4
H Joseph Yost
Co-authored papers 4
David Pincus
Co-authored papers 4
Priyanka Narayan
Co-authored papers 4
M Inmaculada Barrasa
Co-authored papers 4
Leah E Cowen
University of Toronto
Co-authored papers 4
Joshua A Bittker
Co-authored papers 3
Kurt Schellenberg
The Arnold Arboretum of Harvard University
Co-authored papers 3
Song Yi
Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin
Co-authored papers 3
Nancy U Lin
Co-authored papers 3
Charles Boone
University of Toronto
Co-authored papers 3
Nidhi Sahni
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
William R Hesse
Co-authored papers 3
Stuart L Schreiber
Broad Institute
Co-authored papers 3
Giorgio Gaglia
Co-authored papers 3
Release 1.2