Author details

Full Name

Dan Donnelly

Affiliation

University of Leeds

ORCID

Career Start Year

1989

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
29397068	A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics.	Biochem Biophys Res Commun	2018
28012961	High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH<sub>2</sub>) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.	Biochem Pharmacol	2017
27630114	Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.	Pharmacol Rev	2016
26598711	The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.	Biosci Rep	2015
24491483	Pharmacophore model of the quercetin binding site of the SIRT6 protein.	J Mol Graph Model	2014
25218037	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Peptides	2014
25191754	The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.	PLoS One	2014
25158085	N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity.	ACS Chem Biol	2014
21950636	The structure and function of the glucagon-like peptide-1 receptor and its ligands.	Br J Pharmacol	2012
19913063	Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor.	Peptides	2010
20869417	Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.	Peptides	2010
20600126	Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.	J Mol Biol	2010
20649595	The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.	Br J Pharmacol	2010
19914210	Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.	Biochem Biophys Res Commun	2010
18539702	Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.	Mol Pharmacol	2008
18779825	Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model.	Int J Obes (Lond)	2008
17635131	Peptide binding at the GLP-1 receptor.	Biochem Soc Trans	2007
16343447	Conformational induction is the key process for activation of the AT1 receptor.	Biochem Pharmacol	2006
15620728	MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3.	FEBS Lett	2005
14965273	The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists.	Protein Pept Lett	2004
14965274	Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues.	Protein Pept Lett	2004
12524435	The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.	J Biol Chem	2003
12970080	A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors.	Br J Pharmacol	2003
14572647	The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists.	FEBS Lett	2003
12387900	The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge.	FEBS Lett	2002
10085227	Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.	Biochem J	1999
9766007	Over-expression of the N-terminal domain of the glucagon-like peptide-1 receptor in Escherichia coli.	Biochem Soc Trans	1998
9690859	The relationship between the agonist-induced activation and desensitization of the human tachykinin NK2 receptor expressed in Xenopus oocytes.	Br J Pharmacol	1998
9020140	The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.	J Biol Chem	1997
9224704	The arrangement of the transmembrane helices in the secretin receptor family of G-protein-coupled receptors.	FEBS Lett	1997
9388598	G-protein-coupled receptors for peptide hormones: angiotensin II receptors.	Biochem Soc Trans	1997
8663137	Additions and Corrections to The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.	J Biol Chem	1996
7961636	The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.	J Biol Chem	1994
8081733	The evolution and structure of aminergic G protein-coupled receptors.	Recept Channels	1994
8073034	The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules.	Protein Eng	1994
8132083	Structure of G-protein-linked receptors.	Biochem Soc Trans	1993
8449316	Modelling alpha-helical transmembrane domains.	Biochem Soc Trans	1993
8443590	Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues.	Protein Sci	1993
8234233	Predicting the point at which transmembrane helices protrude from the bilayer: a model of the antenna complexes from photosynthetic bacteria.	Protein Eng	1993
1304904	Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds.	Protein Sci	1992
24408780	A three-dimensional model of the Photosystem II reaction centre of Pisum sativum.	Photosynth Res	1992
2546817	An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors. Implications for the three-dimensional structure.	FEBS Lett	1989

1 - 42 of 42

Fan Wu

ShanghaiTech University

Career Start Year 2017

Number of shared co-authors 1

Michael J Robertson

Stanford University School of Medicine

Career Start Year 2015

Number of shared co-authors 0

Joel Karpiak

Department of Pharmaceutical Sciences, University of California San Francisco

Career Start Year 2009

Number of shared co-authors 1

Aashish Manglik

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 2008

Number of shared co-authors 1

Andrew C Kruse

Blavatnik Institute, Harvard Medical School

Career Start Year 2008

Number of shared co-authors 0

Suwen Zhao

ShanghaiTech University, China iHuman Institute

Career Start Year 2006

Number of shared co-authors 1

Brian E Krumm

University of North Carolina School of Medicine

Career Start Year 2003

Number of shared co-authors 0

Anita M Preininger

IBM Corporation

Career Start Year 2002

Number of shared co-authors 0

Christopher J Langmead

Monash University

Career Start Year 2000

Number of shared co-authors 0

Joseph D Ho

University of California san francisco

Career Start Year 2000

Number of shared co-authors 1

Judith Klein-Seetharaman

School of Molecular Sciences & College of Health Solutions, Arizona State University

Career Start Year 1999

Number of shared co-authors 1

Peter Kolb

Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg

Career Start Year 1996

Number of shared co-authors 1

Xi-Ping Huang

University of North Carolina School of Medicine

Career Start Year 1992

Number of shared co-authors 2

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 0

Howard Broughton

Lilly Research Laboratories

Career Start Year 1990

Number of shared co-authors 1

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 1

Herman W T van Vlijmen

Leiden Academic Centre for Drug Research (LACDR), Leiden University

Career Start Year 1988

Number of shared co-authors 2

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 1

Patrick R Griffin

The Scripps Research Institute

Career Start Year 1987

Number of shared co-authors 1

Senyon Choe

Joint Center for Biosciences

Career Start Year 1986

Number of shared co-authors 1

Stanley R Krystek

Bristol-Myers Squibb Pharmaceutical Research Institute

Career Start Year 1985

Number of shared co-authors 1

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Career Start Year 1984

Number of shared co-authors 1

Michel Bouvier

Institute for Research in Immunology and Cancer, Universite de Montreal

Career Start Year 1981

Number of shared co-authors 0

Ruben Abagyan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Career Start Year 1981

Number of shared co-authors 0

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 1

Harel Weinstein

Institute for Computational Biomedicine

Career Start Year 1973

Number of shared co-authors 1

Bernard Maigret

Universite de Lorraine, CNRS

Career Start Year 1970

Number of shared co-authors 1

Horst Kessler

Institute for Advanced Study, Technical University Munich

Career Start Year 1966

Number of shared co-authors 1

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 1

Jens Meiler

Vanderbilt University

Career Start Year 1954

Number of shared co-authors 1

row(s) 1 - 30 of 30

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Co-authored papers 6

Anthony J Balmforth

Co-authored papers 4

John P Overington

Institute of Cardiovascular Science, University College London

Co-authored papers 3

Stephen G Ball

Co-authored papers 2

Mark S Johnson

Abo Akademi University

Co-authored papers 2

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Teresa K Attwood

Co-authored papers 1

Sebastian D Fugmann

Institute of Biomedical Sciences, College of Medicine, Chang Gung University

Co-authored papers 1

1 - 8

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