Author details

Full Name

Alan R Fersht

Affiliation

Medical Research Council Laboratory of Molecular Biology

ORCID

Career Start Year

1967

Papers

551

H Index

127

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34087198	AlphaFold - A Personal Perspective on the Impact of Machine Learning.	J Mol Biol	2021
34089216	NF-ÎºB Rel subunit exchange on a physiological timescale.	Protein Sci	2021
31769931	ChemBioChem@20-Some Reflections.	Chembiochem	2020
31990523	Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.	ACS Chem Biol	2020
31633398	A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.	Future Med Chem	2019
31405179	SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.	Cancers (Basel)	2019
29069577	Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.	Cancer Lett	2018
30068941	Correction: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus.	Oncogene	2018
29702446	Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.	Eur J Med Chem	2018
29382728	The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.	J Biol Chem	2018
28508083	Structures of closed and open conformations of dimeric human ATM.	Sci Adv	2017
28292898	Multisite aggregation of p53 and implications for drug rescue.	Proc Natl Acad Sci U S A	2017
27551077	2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.	Proc Natl Acad Sci U S A	2016
27821763	Design of a molecular support for cryo-EM structure determination.	Proc Natl Acad Sci U S A	2016
27503952	An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.	Protein Eng Des Sel	2016
27267810	Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.	ACS Chem Biol	2016
27145840	The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.	Annu Rev Biochem	2016
25675526	Mechanism of initiation of aggregation of p53 revealed by Î¦-value analysis.	Proc Natl Acad Sci U S A	2015
26378745	Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.	ACS Chem Biol	2015
26636255	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.	Structure	2015
25946337	Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation.	PLoS One	2015
25675527	Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.	Proc Natl Acad Sci U S A	2015
22777995	Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase.	Angew Chem Int Ed Engl	2013
24277833	Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry.	Proc Natl Acad Sci U S A	2013
24127580	MDMX contains an autoinhibitory sequence element.	Proc Natl Acad Sci U S A	2013
23630318	Small molecule induced reactivation of mutant p53 in cancer cells.	Nucleic Acids Res	2013
23675589	Reply to Campos and MuÃ±oz: Why phosphate is a bad buffer for guanidinium chloride titrations.	Proc Natl Acad Sci U S A	2013
23329326	Don't waste good methods on bad buffers and ambiguous data.	Proc Natl Acad Sci U S A	2013
22176582	Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53.	J Am Chem Soc	2012
22972749	Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.	Proc Natl Acad Sci U S A	2012
23012405	Sequence-dependent sliding kinetics of p53.	Proc Natl Acad Sci U S A	2012
22955930	In support of the BMRB.	Nat Struct Mol Biol	2012
23035244	Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.	Proc Natl Acad Sci U S A	2012
23112865	Stability of p53 homologs.	PLoS One	2012
23112193	Chemical physics of protein folding.	Proc Natl Acad Sci U S A	2012
23135266	Evaluating Drosophila p53 as a model system for studying cancer mutations.	J Biol Chem	2012
22869713	Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition.	Proc Natl Acad Sci U S A	2012
22869710	First-order rate-determining aggregation mechanism of p53 and its implications.	Proc Natl Acad Sci U S A	2012
22439615	Halogen-enriched fragment libraries as leads for drug rescue of mutant p53.	J Am Chem Soc	2012
20650962	Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant.	Protein Eng Des Sel	2011
21525412	Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration.	Proc Natl Acad Sci U S A	2011
21553833	Combination of Markov state models and kinetic networks for the analysis of molecular dynamics simulations of peptide folding.	J Phys Chem B	2011
21639149	Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study.	J Am Chem Soc	2011
21491862	Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.	J Am Chem Soc	2011
21457718	Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer.	J Mol Biol	2011
21422286	Malleability of folding intermediates in the homeodomain superfamily.	Proc Natl Acad Sci U S A	2011
21146541	Time-resolved small-angle X-ray scattering study of the folding dynamics of barnase.	J Mol Biol	2011
21037279	Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters.	Protein Eng Des Sel	2011
21097469	Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.	Nucleic Acids Res	2011
21187427	Folding of the Pit1 homeodomain near the speed limit.	Proc Natl Acad Sci U S A	2011

1 - 50 of 551

Lewyn Li

Dana-Farber Cancer Institute, Harvard Medical School

Career Start Year 2000

Number of shared co-authors 1

J Michael Sauder

Eli Lilly and Co.

Career Start Year 1996

Number of shared co-authors 3

Shira Albeck

Weizmann Institute of Science

Career Start Year 1996

Number of shared co-authors 6

Andreas Bracher

Max-Planck-Institute of Biochemistry

Career Start Year 1995

Number of shared co-authors 3

Orly Dym

Weizmann Institute of Science

Career Start Year 1995

Number of shared co-authors 6

Volker D??tsch

Institute for Biophysical Chemistry, Goethe-University

Career Start Year 1995

Number of shared co-authors 6

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 7

Tobin R Sosnick

Institute for Biophysical Dynamics, The University of Chicago

Career Start Year 1990

Number of shared co-authors 5

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 3

John F Hunt

Columbia University

Career Start Year 1986

Number of shared co-authors 5

Arun Malhotra

University of Miami Miller School of Medicine

Career Start Year 1986

Number of shared co-authors 2

Raghavan Varadarajan

Indian Institute of Science

Career Start Year 1985

Number of shared co-authors 2

Aled M Edwards

University of Toronto

Career Start Year 1984

Number of shared co-authors 5

Stephen Anderson

Center for Advanced Biotechnology and Medicine, Rutgers University

Career Start Year 1983

Number of shared co-authors 3

Vladimir N Malashkevich

Albert Einstein College of Medicine

Career Start Year 1982

Number of shared co-authors 1

Udo Heinemann

Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)

Career Start Year 1980

Number of shared co-authors 4

Ruth Nussinov

Sackler School of Medicine, Tel Aviv University

Career Start Year 1980

Number of shared co-authors 5

Alan R Davidson

University of Toronto, University Avenue

Career Start Year 1980

Number of shared co-authors 8

Michael Brenowitz

Albert Einstein College of Medicine

Career Start Year 1979

Number of shared co-authors 2

Andrzej Joachimiak

Center for Structural Biology of Infectious Diseases, University of Chicago

Career Start Year 1979

Number of shared co-authors 8

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 4

John A Tainer

The University of Texas MD Anderson Cancer Center

Career Start Year 1975

Number of shared co-authors 5

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 6

Charles L Brooks

University of Michigan ann arbor

Career Start Year 1974

Number of shared co-authors 4

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 9

Barry Honig

Columbia University Irving Medical Center

Career Start Year 1971

Number of shared co-authors 4

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 3

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 4

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 7

Martin Karplus

Harvard University

Career Start Year 1959

Number of shared co-authors 12

row(s) 1 - 30 of 30

Gideon Schreiber

Co-authored papers 14

Kim Henrick

The State University of New Jersey

Co-authored papers 5

Hartmut Oschkinat

Leibniz-Forschungsinstitut fur Molekulare Pharmakologie

Co-authored papers 5

Carol V Robinson

University of Oxford

Co-authored papers 5

Fernando J Corrales

National Center for Biotechnology

Co-authored papers 5

Lewis E Kay

University of Toronto

Co-authored papers 4

Dmitry M Korzhnev

University of Connecticut Health Center

Co-authored papers 4

Mary M Y Waye

The Chinese University of Hong Kong

Co-authored papers 4

Leonid A Mirny

Co-authored papers 3

Gordon C K Roberts

Leicester Institute of Structural and Chemical Biology, University of Leicester

Co-authored papers 2

Osnat Karni

Columbia University

Co-authored papers 2

Jose Maria Carazo

National Centre for Biotechnology (CNB CSIC), Campus Universidad Autonoma de Madrid

Co-authored papers 2

Mikel Valle

Center for Cooperative Research in Biosciences (CIC bioGUNE)

Co-authored papers 2

Michael J E Sternberg

Imperial College London

Co-authored papers 2

Michele Vendruscolo

University of Cambridge

Co-authored papers 2

Dmitri I Svergun

King's College London BHF Centre for Research Excellence

Co-authored papers 2

Sjors H W Scheres

Medical Research Council Laboratory of Molecular Biology

Co-authored papers 2

Ad Bax

National Institutes of Health

Co-authored papers 2

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Oliver F Lange

Center for Integrated Protein Science, Technische Universitat Munchen

Co-authored papers 1

Josep Rizo

University of Texas Southwestern Medical Center

Co-authored papers 1

Mike P Williamson

The University of Sheffield

Co-authored papers 1

Fred E Cohen

University of California san francisco

Co-authored papers 1

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Co-authored papers 1

Igor L Barsukov

Institute of Integrative Biology, University of Liverpool

Co-authored papers 1

David E Shaw

Columbia University

Co-authored papers 1

Patrick C A van der Wel

Zernike Institute for Advanced Materials, University of Groningen

Co-authored papers 1

David Middleton

Co-authored papers 1

Ioannis Vakonakis

University of Oxford

Co-authored papers 1

Thomas A Frenkiel

The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute

Co-authored papers 1

1 - 30

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