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Author Details

Scott J Weir
University of Kansas Medical Center
1985
90
29
PMIDPaper TitleJournal TitlePublished Year
36218231Doublecortin-like kinase 1 is a therapeutic target in squamous cell carcinoma.Mol Carcinog2023
37190159Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.Cancers (Basel)2023
37047307Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer.Int J Mol Sci2023
34559922Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer.Mol Carcinog2022
36276125Novel compound C150 inhibits pancreatic cancer through induction of ER stress and proteosome assembly.Front Oncol2022
35868306Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.Cancer Cell2022
33305598Targeting Major Signaling Pathways of Bladder Cancer with Phytochemicals: A Review.Nutr Cancer2021
33745223CCN5 activation by free or encapsulated EGCG is required to render triple-negative breast cancer cell viability and tumor progression.Pharmacol Res Perspect2021
34976816Novel Compound C150 Inhibits Pancreatic Cancer Cell Epithelial-to-Mesenchymal Transition and Tumor Growth in Mice.Front Oncol2021
34206989Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis.Cells2021
34059639Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex.Cell Death Dis2021
34022283Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.Cancer Lett2021
32313104Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells.Nat Cell Biol2020
31786131Diphenylbutylpiperidine Antipsychotic Drugs Inhibit Prolactin Receptor Signaling to Reduce Growth of Pancreatic Ductal Adenocarcinoma in Mice.Gastroenterology2020
31992775Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway.Sci Rep2020
32094348Suppressing STAT5 signaling affects osteosarcoma growth and stemness.Cell Death Dis2020
32740891A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease.Stem Cell Rev Rep2020
30674533Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response.Cancer Res2019
31442435The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.Gastroenterology2019
31608135Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone.Oncotarget2019
30832788Progress in Drug Discovery in Academia and Persistent Challenges of "the Valley of Death".Mayo Clin Proc2019
30914802MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential.Nat Rev Urol2019
31113837Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs.J Pharmacol Exp Ther2019
31025088Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.J Mol Med (Berl)2019
29458417Cooperative p16 and p21 action protects female astrocytes from transformation.Acta Neuropathol Commun2018
30333627Functional genomic landscape of acute myeloid leukaemia.Nature2018
29579058Comparative oncology approach to drug repurposing in osteosarcoma.PLoS One2018
27863422In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma.Oncotarget2017
28295989Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia.Pediatr Blood Cancer2017
27536557Targeting p97 to Disrupt Protein Homeostasis in Cancer.Front Oncol2016
26331352RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells.Mol Carcinog2016
26673007Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells.Oncotarget2016
27677075Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.Oncotarget2016
27775703DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.Nat Cell Biol2016
25898813A phase I study of intraperitoneal nanoparticulate paclitaxel (Nanotax®) in patients with peritoneal malignancies.Cancer Chemother Pharmacol2015
24273151Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.Am J Hematol2014
25122069Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor.Mol Cancer Ther2014
23157466Population pharmacokinetics and pharmacodynamics of dalfampridine-ER in healthy volunteers and in patients with multiple sclerosis.Curr Med Res Opin2013
23657945Drug repurposing for gastrointestinal stromal tumor.Mol Cancer Ther2013
23157467Pharmacokinetic profile of dalfampridine extended release: clinical relevance in patients with multiple sclerosis.Curr Med Res Opin2013
22246671Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.Cancer Res2012
22532602CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis.Mol Cancer Ther2012
22521610Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.Toxicol Appl Pharmacol2012
22650244A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct.J Med Chem2012
21366640The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy.J Clin Pharm Ther2011
22009536Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.Cancer Res2011
21511957New sources of drugs for hematologic malignancies.Blood2011
20026673Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics.J Pharmacol Exp Ther2010
20942408Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.J Med Chem2010
18020335A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.J Am Chem Soc2007
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1 Vanderbilt University Medical Center
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Collaborators

University of Kansas Medical Center
Co-authored papers 5
University of Kansas
Co-authored papers 5
Princess Margaret Cancer Centre
Co-authored papers 4
University of Kansas Medical Center
Co-authored papers 3
Oregon Health and Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 2
Co-authored papers 2
The Ohio State University
Co-authored papers 2
Clinical Research Services, University of Miami Sylvester Comprehensive Cancer Center
Co-authored papers 2
University of Colorado Division of Hematology
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Astex Pharmaceuticals
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Oregon Health & Science University, Knight Cancer Institute
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Emory School of Medicine
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health Sciences University
Co-authored papers 2
National Cancer Institute, National Institutes of Health
Co-authored papers 2
University of Miami, Sylvester Comprehensive Cancer Center
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 2